This entry includes small conductance mechanosensitive channels (MscS), which assembles to a homoheptameric complex [[cite:PUB00019883],[cite:PUB00019884],[cite:PUB00019885],[cite:PUB00101036],[cite:PUB00062568],[cite:PUB00101037]]. Each monomer consists of a N-terminal transmembrane region and a large cytoplasmic segment composed of a five-stranded antiparallel beta-sheet (middle/second) domain and a C-terminal alpha/beta-domain [[cite:PUB00101036],[cite:PUB00062568],[cite:PUB00101037],[cite:PUB00064132]]. This is the beta domain which adopts a Sm-like barrel structure.
","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Small-conductance_mechanosensitive_channel","extract":"Small conductance mechanosensitive ion channels (MscS) provide protection against hypo-osmotic shock in bacteria, responding both to stretching of the cell membrane and to membrane depolarization. In eukaryotes, they fulfill a multitude of important functions in addition to osmoregulation. They are present in the membranes of organisms from the three domains of life: bacteria, archaea, fungi and plants.
","thumbnail":null}],"literature":{"PUB00101037":{"PMID":23339071,"ISBN":null,"volume":"22","issue":"4","year":2013,"title":"Open and shut: crystal structures of the dodecylmaltoside solubilized mechanosensitive channel of small conductance from Escherichia coli and Helicobacter pylori at 4.4 A and 4.1 A resolutions.","URL":null,"raw_pages":"502-9","medline_journal":"Protein Sci","ISO_journal":"Protein Sci","authors":["Lai JY","Poon YS","Kaiser JT","Rees DC."],"DOI_URL":null},"PUB00062568":{"PMID":23012406,"ISBN":null,"volume":"109","issue":"40","year":2012,"title":"Conformational state of the MscS mechanosensitive channel in solution revealed by pulsed electron-electron double resonance (PELDOR) spectroscopy.","URL":null,"raw_pages":"E2675-82","medline_journal":"Proc Natl Acad Sci U S A","ISO_journal":"Proc. Natl. Acad. Sci. U.S.A.","authors":["Pliotas C","Ward R","Branigan E","Rasmussen A","Hagelueken G","Huang H","Black SS","Booth IR","Schiemann O","Naismith JH."],"DOI_URL":"http://dx.doi.org/10.1073/pnas.1202286109"},"PUB00101036":{"PMID":34376558,"ISBN":null,"volume":"118","issue":"33","year":2021,"title":"Mechanosensitive channel gating by delipidation. ","URL":null,"raw_pages":"e2107095118","medline_journal":"Proc Natl Acad Sci U S A","ISO_journal":"Proc Natl Acad Sci U S A","authors":["Flegler VJ","Rasmussen A","Borbil K","Boten L","Chen HA","Deinlein H","Halang J","Hellmanzik K","Loffler J","Schmidt V","Makbul C","Kraft C","Hedrich R","Rasmussen T","Bottcher B."],"DOI_URL":null},"PUB00019884":{"PMID":11159397,"ISBN":null,"volume":"80","issue":"1","year":2001,"title":"Molecular identification of a mechanosensitive channel in archaea.","URL":null,"raw_pages":"229-40","medline_journal":"Biophys J","ISO_journal":"Biophys. J.","authors":["Kloda A","Martinac B."],"DOI_URL":"http://ukpmc.ac.uk/picrender.cgi?tool=EBI&pubmedid=11159397&action=stream&blobtype=pdf"},"PUB00019885":{"PMID":11275684,"ISBN":null,"volume":"11","issue":"2","year":2001,"title":"Mechanosensitive channels in prokaryotes.","URL":null,"raw_pages":"61-76","medline_journal":"Cell Physiol Biochem","ISO_journal":"Cell. Physiol. Biochem.","authors":["Martinac B."],"DOI_URL":"http://dx.doi.org/10.1159/000047793"},"PUB00019883":{"PMID":11296222,"ISBN":null,"volume":"20","issue":"8","year":2001,"title":"Structural and functional differences between two homologous mechanosensitive channels of Methanococcus jannaschii.","URL":null,"raw_pages":"1888-96","medline_journal":"EMBO J","ISO_journal":"EMBO J.","authors":["Kloda A","Martinac B."],"DOI_URL":"http://dx.doi.org/10.1093/emboj/20.8.1888"},"PUB00064132":{"PMID":23074248,"ISBN":null,"volume":"109","issue":"44","year":2012,"title":"Structure and molecular mechanism of an anion-selective mechanosensitive channel of small conductance.","URL":null,"raw_pages":"18180-5","medline_journal":"Proc Natl Acad Sci U S A","ISO_journal":"Proc. Natl. Acad. Sci. U.S.A.","authors":["Zhang X","Wang J","Feng Y","Ge J","Li W","Sun W","Iscla I","Yu J","Blount P","Li Y","Yang M."],"DOI_URL":"http://dx.doi.org/10.1073/pnas.1207977109"}},"set_info":{"accession":"CL0986","name":"Sm-like"},"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":274,"interactions":0,"matches":69995,"pathways":0,"proteins":69957,"proteomes":20063,"sets":1,"structural_models":{"alphafold":46372},"structures":65,"taxa":30243},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":35,"alignment:full":35219},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}