This family is the Small Multidrug Resistance (SMR) family. Several members have been shown to export a range of toxins, including ethidium bromide ([[cite:PUB00019898]] and quaternary ammonium compounds [[cite:PUB00002174]], through coupling with proton influx [[cite:PUB00019899]].
","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Small_multidrug_resistance_protein","extract":"Small multidrug resistance proteins are a family of integral membrane proteins that confer drug resistance to a wide range of toxic compounds including guanidinium, hydrophobic drugs, antiseptics, polyamines, and glycolipids, by removing them for the cells. Within the family there are four subtypes. Small multidrug resistance proteins are characterized by four α-helical transmembrane strands. SMR proteins are some of the smallest membrane transport proteins found in nature. The efflux is coupled to an influx of protons. An example is Escherichia coli mvrC P23895 which prevents the incorporation of methyl viologen into cells and is involved in ethidium bromide efflux.
","thumbnail":null}],"literature":{"PUB00019898":{"PMID":2602117,"ISBN":null,"volume":"17","issue":"23","year":1989,"title":"Nucleotide sequence of a gene that encodes resistance to ethidium bromide from a transferable plasmid in Staphylococcus aureus.","URL":null,"raw_pages":"10103","medline_journal":"Nucleic Acids Res","ISO_journal":"Nucleic Acids Res.","authors":["Sasatsu M","Shima K","Shibata Y","Kono M."],"DOI_URL":"http://dx.doi.org/10.1093/nar/17.23.10103"},"PUB00019899":{"PMID":7896833,"ISBN":null,"volume":"270","issue":"12","year":1995,"title":"EmrE, an Escherichia coli 12-kDa multidrug transporter, exchanges toxic cations and H+ and is soluble in organic solvents.","URL":null,"raw_pages":"6856-63","medline_journal":"J Biol Chem","ISO_journal":"J. Biol. Chem.","authors":["Yerushalmi H","Lebendiker M","Schuldiner S."],"DOI_URL":"http://dx.doi.org/10.1074/jbc.270.12.6856"},"PUB00002174":{"PMID":1314803,"ISBN":null,"volume":"174","issue":"9","year":1992,"title":"The chloramphenicol acetyltransferase gene of Tn2424: a new breed of cat.","URL":null,"raw_pages":"2891-7","medline_journal":"J Bacteriol","ISO_journal":"J. Bacteriol.","authors":["Parent R","Roy PH."],"DOI_URL":"http://jb.asm.org/cgi/content/abstract/174/9/2891"}},"set_info":{"accession":"CL0184","name":"DMT"},"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":11,"interactions":0,"matches":28666,"pathways":0,"proteins":28663,"proteomes":13207,"sets":1,"structural_models":{"alphafold":17571},"structures":20,"taxa":18029},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":13,"alignment:full":12056},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}