{"metadata":{"accession":"PF00892","entry_id":null,"type":"domain","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR000620","hierarchy":null,"name":{"name":"EamA-like transporter family","short":"EamA"},"description":[{"text":"<p>This family includes many hypothetical membrane proteins of unknown function. Many of the proteins contain two copies of the aligned region. The family used to be known as DUF6. Members of this family usually carry 5+5 transmembrane domains, and this domain attempts to model five of these.</p>","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"EamA","extract":"<p><b>EamA</b> is a protein domain found in a wide range of proteins including the <i>Erwinia chrysanthemi</i> PecM protein, which is involved in pectinase, cellulase and blue pigment regulation, the <i>Salmonella typhimurium</i> PagO protein, and some members of the solute carrier family group 35 (SLC35) nucleoside-sugar transporters. Many members of this family have no known function and are predicted to be integral membrane proteins and many of the proteins contain two copies of the domain.</p>","thumbnail":null},{"title":"Small_multidrug_resistance_protein","extract":"<p><b>Small multidrug resistance proteins</b> are a family of integral membrane proteins that confer drug resistance to a wide range of toxic compounds including guanidinium, hydrophobic drugs, antiseptics, polyamines, and glycolipids, by removing them for the cells. Within the family there are four subtypes. Small multidrug resistance proteins are characterized by four α-helical transmembrane strands. SMR proteins are some of the smallest membrane transport proteins found in nature. The efflux is coupled to an influx of protons. An example is <i>Escherichia coli</i> mvrC <span class=\"plainlinks\"><span class=\"external text\">P23895</span></span> which prevents the incorporation of methyl viologen into cells and is involved in ethidium bromide efflux.</p>","thumbnail":null}],"literature":null,"set_info":{"accession":"CL0184","name":"DMT"},"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":602,"interactions":0,"matches":383832,"pathways":0,"proteins":219191,"proteomes":21278,"sets":1,"structural_models":{"alphafold":143070},"structures":3,"taxa":34197},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":99,"alignment:full":192339},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}