{"metadata":{"accession":"PF00520","entry_id":null,"type":"family","go_terms":null,"source_database":"pfam","member_databases":null,"integrated":"IPR005821","hierarchy":null,"name":{"name":"Ion transport protein","short":"Ion_trans"},"description":[{"text":"

This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.

","llm":false,"checked":false,"updated":false}],"wikipedia":[{"title":"Cation_channel_superfamily","extract":"

The transmembrane cation channel superfamily was defined in InterPro and Pfam as the family of tetrameric ion channels. These include the sodium, potassium, calcium, ryanodine receptor, HCN, CNG, CatSper, and TRP channels. This large group of ion channels apparently includes families 1.A.1, 1.A.2, 1.A.3, and 1.A.4 of the TCDB transporter classification.

","thumbnail":null},{"title":"Transient_receptor_potential_calcium_channel_family","extract":"

The transient receptor potential Ca2+ channel (TRP-CC) family (TC# 1.A.4) is a member of the voltage-gated ion channel (VIC) superfamily and consists of cation channels conserved from worms to humans. The TRP-CC family also consists of seven subfamilies (TRPC, TRPV, TRPM, TRPN, TRPA, TRPP, and TRPML) based on their amino acid sequence homology:

  1. the canonical or classic TRPs,
    2. \n
  2. the vanilloid receptor TRPs,
    3. \n
  3. the melastatin or long TRPs,
    4. \n
  4. ankyrin (whose only member is the transmembrane protein 1 [TRPA1])
    5. \n
  5. TRPN after the nonmechanoreceptor potential C (nonpC), and the more distant cousins,
    6. \n
  6. the polycystins
    7. \n
  7. and mucolipins.
","thumbnail":null},{"title":"Voltage-gated_potassium_channel","extract":"

Voltage-gated potassium channels (VGKCs) are transmembrane channels specific for potassium and sensitive to voltage changes in the cell's membrane potential. During action potentials, they play a crucial role in returning the depolarized cell to a resting state.

","thumbnail":null}],"literature":null,"set_info":{"accession":"CL0030","name":"Ion_channel"},"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":3790,"interactions":0,"matches":389397,"pathways":0,"proteins":241867,"proteomes":10567,"sets":1,"structural_models":{"alphafold":155893,"bfvd":0},"structures":1115,"taxa":26805},"entry_annotations":{"hmm":0,"logo":0,"alignment:seed":243,"alignment:full":258114},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":{"accession":"1ors","name":"X-ray structure of the KvAP potassium channel voltage sensor in complex with an Fab"}}}