{"metadata":{"accession":"PTHR23287","entry_id":null,"type":"family","go_terms":null,"source_database":"panther","member_databases":null,"integrated":null,"hierarchy":null,"name":{"name":"Hermansky-Pudlak syndrome 5 (HPS5)","short":"HPS5"},"description":[{"text":"The HPS5 family proteins are primarily involved in the biogenesis of specialized organelles such as eye pigment granules, which are akin to late endosomes or lysosomes. These proteins are essential for the delivery of molecular components to lysosomes, a process crucial for the formation of pigment granules in the eye. In humans and mice, HPS5 family members are implicated in the regulation of lysosome synthesis and function, as well as the formation of melanosomes and platelet dense granules. They also play a role in intracellular vesicular trafficking in fibroblasts and may influence the general functions of integrins.","llm":true,"checked":false,"updated":false}],"wikipedia":null,"literature":null,"set_info":null,"overlaps_with":null,"counters":{"subfamilies":2,"domain_architectures":0,"interactions":0,"matches":3940,"pathways":0,"proteins":3940,"proteomes":1231,"sets":0,"structural_models":{"alphafold":2693,"bfvd":0},"structures":0,"taxa":4181},"entry_annotations":{"hmm":0,"logo":0},"cross_references":{},"is_llm":true,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}