{"metadata":{"accession":"PTHR14471","entry_id":null,"type":"family","go_terms":null,"source_database":"panther","member_databases":null,"integrated":"IPR052297","hierarchy":null,"name":{"name":"RING-CH-type E3 ubiquitin-protein ligase","short":"RING-CH-type_E3_ubiq-ligase"},"description":[{"text":"This family of proteins includes E3 ubiquitin-protein ligases with a RING-CH-type zinc finger domain essential for their ligase activity. These enzymes facilitate the transfer of ubiquitin from E2 ubiquitin-conjugating enzymes to specific substrate proteins, thereby tagging them for various cellular processes. The ubiquitination can lead to different outcomes, including protein degradation, cellular signaling, and trafficking. Members of this family are involved in several cellular processes such as T-cell proliferation, lysosome homeostasis, and autophagy regulation. They are known to promote mixed polyubiquitination on certain targets, which can inhibit autophagy or regulate inflammatory responses by targeting components of the inflammasome for degradation.","llm":true,"checked":false,"updated":false}],"wikipedia":null,"literature":null,"set_info":null,"overlaps_with":null,"counters":{"subfamilies":2,"domain_architectures":0,"interactions":0,"matches":2125,"pathways":0,"proteins":2125,"proteomes":711,"sets":0,"structural_models":{"alphafold":1931,"bfvd":0},"structures":0,"taxa":2234},"entry_annotations":{"hmm":0,"logo":0},"cross_references":{},"is_llm":true,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}