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{
    "metadata": {
        "accession": "TIGR02258",
        "entry_id": null,
        "type": "family",
        "go_terms": null,
        "source_database": "ncbifam",
        "member_databases": null,
        "integrated": "IPR004175",
        "hierarchy": null,
        "name": {
            "name": "RNA 2',3'-cyclic phosphodiesterase",
            "short": "2_5_ligase"
        },
        "description": [
            {
                "text": "<p>ThpR (two-histidine 2',3'-cyclic phosphodiesterase acting on RNA) was formerly named LigT, and called a 2'-5' RNA ligase, based on its ability to perform a reversible, ATP-independent 2'-5'-ligation of what is presumably a non-phyiological substrate: half-tRNA splice intermediates from an intron-containing yeast tRNA. The more recent characterization in [cite:PUB00075358] clarifies the likely biological role.</p>",
                "llm": false,
                "checked": false,
                "updated": false
            }
        ],
        "wikipedia": null,
        "literature": {
            "PUB00075358": {
                "PMID": 25239919,
                "ISBN": null,
                "volume": "20",
                "issue": "11",
                "year": 2014,
                "title": "Structure and mechanism of E. coli RNA 2',3'-cyclic phosphodiesterase.",
                "URL": null,
                "raw_pages": "1697-705",
                "medline_journal": "RNA",
                "ISO_journal": "RNA",
                "authors": [
                    "Remus BS",
                    "Jacewicz A",
                    "Shuman S."
                ],
                "DOI_URL": "http://dx.doi.org/10.1261/rna.046797.114"
            },
            "PUB00016758": {
                "PMID": 8940112,
                "ISBN": null,
                "volume": "271",
                "issue": "49",
                "year": 1996,
                "title": "The 2'-5' RNA ligase of Escherichia coli. Purification, cloning, and genomic disruption.",
                "URL": null,
                "raw_pages": "31145-53",
                "medline_journal": "J Biol Chem",
                "ISO_journal": "J. Biol. Chem.",
                "authors": [
                    "Arn EA",
                    "Abelson JN."
                ],
                "DOI_URL": "http://dx.doi.org/10.1074/jbc.271.49.31145"
            },
            "PUB00017746": {
                "PMID": 12798681,
                "ISBN": null,
                "volume": "329",
                "issue": "5",
                "year": 2003,
                "title": "Crystal structure of the 2'-5' RNA ligase from Thermus thermophilus HB8.",
                "URL": null,
                "raw_pages": "903-11",
                "medline_journal": "J Mol Biol",
                "ISO_journal": "J. Mol. Biol.",
                "authors": [
                    "Kato M",
                    "Shirouzu M",
                    "Terada T",
                    "Yamaguchi H",
                    "Murayama K",
                    "Sakai H",
                    "Kuramitsu S",
                    "Yokoyama S."
                ],
                "DOI_URL": "http://dx.doi.org/10.1016/S0022-2836(03)00448-0"
            }
        },
        "set_info": null,
        "overlaps_with": null,
        "counters": {
            "subfamilies": 0,
            "domain_architectures": 0,
            "interactions": 0,
            "matches": 9364,
            "pathways": 0,
            "proteins": 9364,
            "proteomes": 9108,
            "sets": 0,
            "structural_models": {
                "alphafold": 6029
            },
            "structures": 14,
            "taxa": 13458
        },
        "entry_annotations": {
            "hmm": 0,
            "logo": 0
        },
        "cross_references": {},
        "is_llm": false,
        "is_reviewed_llm": false,
        "is_updated_llm": false,
        "representative_structure": {
            "accession": "1vgj",
            "name": "Crystal structure of 2'-5' RNA ligase from Pyrococcus horikoshii"
        }
    }
}