{"metadata":{"accession":"TIGR00149","entry_id":null,"type":"family","go_terms":null,"source_database":"ncbifam","member_databases":null,"integrated":"IPR001602","hierarchy":null,"name":{"name":"secondary thiamine-phosphate synthase enzyme YjbQ","short":"TIGR00149_YjbQ"},"description":[{"text":"<p>Members of this protein family, designated YjbQ in E. coli have been studied extensively by crystallography. Members from several different species have been shown to have sufficient thiamine phosphate synthase activity (EC 2.5.1.3) to complement thiE mutants. However, it is presumed that this is a secondary activity, and the primary function of the YjbQ family enzyme remains unknown.</p>","llm":false,"checked":false,"updated":false}],"wikipedia":null,"literature":{"PUB00101019":{"PMID":21119630,"ISBN":null,"volume":"6","issue":null,"year":2010,"title":"Three serendipitous pathways in E. coli can bypass a block in pyridoxal-5'-phosphate synthesis.","URL":null,"raw_pages":"436","medline_journal":"Mol Syst Biol","ISO_journal":"Mol Syst Biol","authors":["Kim J","Kershner JP","Novikov Y","Shoemaker RK","Copley SD."],"DOI_URL":null},"PUB00101020":{"PMID":18178222,"ISBN":null,"volume":"376","issue":"3","year":2008,"title":"Sensitive genome-wide screen for low secondary enzymatic activities: the YjbQ family shows thiamin phosphate synthase activity.","URL":null,"raw_pages":"839-53","medline_journal":"J Mol Biol","ISO_journal":"J Mol Biol","authors":["Morett E","Saab-Rincon G","Olvera L","Olvera M","Flores H","Grande R."],"DOI_URL":null}},"set_info":null,"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":0,"interactions":0,"matches":16702,"pathways":0,"proteins":16685,"proteomes":10538,"sets":0,"structural_models":{"alphafold":13398,"bfvd":0},"structures":9,"taxa":20721},"entry_annotations":{"hmm":0,"logo":0},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":{"accession":"2p6h","name":"Crystal structure of hypothetical protein APE1520 from Aeropyrum pernix K1"}}}