{"metadata":{"accession":"cd22349","entry_id":null,"type":"domain","go_terms":null,"source_database":"cdd","member_databases":null,"integrated":null,"hierarchy":null,"name":{"name":"Endonuclease domain of segmented negative-strand RNA virus (sNSV) polymerases","short":"PDDEXK_RNA_polymerase-like"},"description":[{"text":"<p>The N-terminal endonuclease domain of sNSV polymerases is essential for viral cap-dependent transcription; it has endonuclease activity and belongs to a superfamily of PDDEXK nucleases including very short patch repair (Vsr) endonucleases, archaeal Holliday junction resolvases, MutH methyl-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and FokI. [[cite:PUB00147263], [cite:PUB00054476]]</p>","llm":false,"checked":false,"updated":false}],"wikipedia":null,"literature":{"PUB00054476":{"PMID":20862319,"ISBN":null,"volume":"6","issue":"9","year":2010,"title":"Bunyaviridae RNA polymerases (L-protein) have an N-terminal, influenza-like endonuclease domain, essential for viral cap-dependent transcription.","URL":null,"raw_pages":null,"medline_journal":"PLoS Pathog","ISO_journal":"PLoS Pathog.","authors":["Reguera J","Weber F","Cusack S."],"DOI_URL":null},"PUB00147263":{"PMID":26004069,"ISBN":null,"volume":"161","issue":"6","year":2015,"title":"Structural Insights into Bunyavirus Replication and Its Regulation by the vRNA Promoter.","URL":null,"raw_pages":"1267-79","medline_journal":"Cell","ISO_journal":"Cell","authors":["Gerlach P","Malet H","Cusack S","Reguera J."],"DOI_URL":null}},"set_info":{"accession":"cl40440","name":"PDDEXK_nuclease-like"},"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":0,"interactions":0,"matches":584,"pathways":0,"proteins":584,"proteomes":116,"sets":1,"structural_models":{"alphafold":0,"bfvd":1},"structures":31,"taxa":301},"entry_annotations":{},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":{"accession":"7ex9","name":"Crystal structure of Ebinur Lake virus cap snatching endonuclease in complex with inhibitor 28"}}}