General Handler

HTTP 200 OK
Allow: GET, HEAD
Content-Type: application/json
InterPro-Version: 108.0
InterPro-Version-Minor: 0
Vary: Accept

{
    "metadata": {
        "accession": "cd22349",
        "entry_id": null,
        "type": "domain",
        "go_terms": null,
        "source_database": "cdd",
        "member_databases": null,
        "integrated": null,
        "hierarchy": null,
        "name": {
            "name": "Endonuclease domain of segmented negative-strand RNA virus (sNSV) polymerases",
            "short": "PDDEXK_RNA_polymerase-like"
        },
        "description": [
            {
                "text": "<p>The N-terminal endonuclease domain of sNSV polymerases is essential for viral cap-dependent transcription; it has endonuclease activity and belongs to a superfamily of PDDEXK nucleases including very short patch repair (Vsr) endonucleases, archaeal Holliday junction resolvases, MutH methyl-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and FokI. [[cite:PUB00147263], [cite:PUB00054476]]</p>",
                "llm": false,
                "checked": false,
                "updated": false
            }
        ],
        "wikipedia": null,
        "literature": {
            "PUB00054476": {
                "PMID": 20862319,
                "ISBN": null,
                "volume": "6",
                "issue": "9",
                "year": 2010,
                "title": "Bunyaviridae RNA polymerases (L-protein) have an N-terminal, influenza-like endonuclease domain, essential for viral cap-dependent transcription.",
                "URL": null,
                "raw_pages": null,
                "medline_journal": "PLoS Pathog",
                "ISO_journal": "PLoS Pathog.",
                "authors": [
                    "Reguera J",
                    "Weber F",
                    "Cusack S."
                ],
                "DOI_URL": null
            },
            "PUB00147263": {
                "PMID": 26004069,
                "ISBN": null,
                "volume": "161",
                "issue": "6",
                "year": 2015,
                "title": "Structural Insights into Bunyavirus Replication and Its Regulation by the vRNA Promoter.",
                "URL": null,
                "raw_pages": "1267-79",
                "medline_journal": "Cell",
                "ISO_journal": "Cell",
                "authors": [
                    "Gerlach P",
                    "Malet H",
                    "Cusack S",
                    "Reguera J."
                ],
                "DOI_URL": null
            }
        },
        "set_info": {
            "accession": "cl40440",
            "name": "PDDEXK_nuclease-like"
        },
        "overlaps_with": null,
        "counters": {
            "subfamilies": 0,
            "domain_architectures": 0,
            "interactions": 0,
            "matches": 584,
            "pathways": 0,
            "proteins": 584,
            "proteomes": 116,
            "sets": 1,
            "structural_models": {
                "alphafold": 0,
                "bfvd": 1
            },
            "structures": 31,
            "taxa": 301
        },
        "entry_annotations": {},
        "cross_references": {},
        "is_llm": false,
        "is_reviewed_llm": false,
        "is_updated_llm": false,
        "representative_structure": {
            "accession": "7ex9",
            "name": "Crystal structure of Ebinur Lake virus cap snatching endonuclease in complex with inhibitor 28"
        }
    }
}