{"metadata":{"accession":"cd22332","entry_id":null,"type":"domain","go_terms":null,"source_database":"cdd","member_databases":null,"integrated":null,"hierarchy":null,"name":{"name":"N-terminal domain of HsdR motor subunit of type I restriction-modification enzyme EcoR124I and similar systems","short":"HsdR_N"},"description":[{"text":"<p>The N-terminal endonuclease-like domain of HsdR motor subunit of type I restriction-modification enzyme EcoR124I belongs to a wider superfamily of PDDEXK nucleases including very short patch repair (Vsr) endonucleases, archaeal Holliday junction resolvases, MutH methyl-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and FokI. [[cite:PUB00049980], [cite:PUB00147257], [cite:PUB00110635], [cite:PUB00110634]]</p>","llm":false,"checked":false,"updated":false}],"wikipedia":null,"literature":{"PUB00049980":{"PMID":19079266,"ISBN":null,"volume":"16","issue":"1","year":2009,"title":"Structure of the motor subunit of type I restriction-modification complex EcoR124I.","URL":null,"raw_pages":"94-5","medline_journal":"Nat Struct Mol Biol","ISO_journal":"Nat. Struct. Mol. Biol.","authors":["Lapkouski M","Panjikar S","Janscak P","Smatanova IK","Carey J","Ettrich R","Csefalvay E."],"DOI_URL":"http://dx.doi.org/10.1038/nsmb.1523"},"PUB00147257":{"PMID":18952104,"ISBN":null,"volume":"384","issue":"5","year":2008,"title":"The interrelationship of helicase and nuclease domains during DNA translocation by the molecular motor EcoR124I.","URL":null,"raw_pages":"1273-86","medline_journal":"J Mol Biol","ISO_journal":"J Mol Biol","authors":["Sisakova E","Weiserova M","Dekker C","Seidel R","Szczelkun MD."],"DOI_URL":null},"PUB00110635":{"PMID":14529527,"ISBN":null,"volume":"4","issue":"5","year":2003,"title":"Crystallographic and bioinformatic studies on restriction endonucleases: inference of evolutionary relationships in the \"midnight zone\" of homology.","URL":null,"raw_pages":"327-37","medline_journal":"Curr Protein Pept Sci","ISO_journal":"Curr Protein Pept Sci","authors":["Bujnicki JM."],"DOI_URL":null},"PUB00110634":{"PMID":10654258,"ISBN":null,"volume":"50","issue":"1","year":2000,"title":"Phylogeny of the restriction endonuclease-like superfamily inferred from comparison of protein structures.","URL":null,"raw_pages":"39-44","medline_journal":"J Mol Evol","ISO_journal":"J Mol Evol","authors":["Bujnicki JM."],"DOI_URL":null}},"set_info":{"accession":"cl40440","name":"PDDEXK_nuclease-like"},"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":0,"interactions":0,"matches":15430,"pathways":0,"proteins":15430,"proteomes":7026,"sets":1,"structural_models":{"alphafold":12272,"bfvd":0},"structures":11,"taxa":14167},"entry_annotations":{},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}