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{
"metadata": {
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"name": {
"name": "synaptotagmin-like mitochondrial-lipid-binding protein (SMP) domain of the extended synaptotagmin (E-Syt) family",
"short": "SMP_ESyt"
},
"description": [
{
"text": "<p>The extended synaptotagmin (E-Syt) family includes a group of Ca2+-regulated intrinsic membrane proteins, such as E-Syt1, E-Syt2 and E-Syt3. They are composed of an N-terminal endoplasmic reticulum (ER)-membrane anchor, a central SMP-domain, and five (E-Syt1) or three C-terminal cytoplasmic C2-domains (E-Syt2 and E-Syt3). The ER-membrane anchor and C2 domains are required for tethering, while the SMP domain is a lipid-binding domain that links the ER with other lipid bilayer-membranes within the cell. This model corresponds to the SMP domain, which has a beta-barrel structure like protein modules in the tubular-lipid-binding (TULIP) superfamily. It dimerizes to form an approximately 90-Angstrom-long cylinder traversed by a channel lined entirely with hydrophobic residues. The following two C2 domains then form arched structures flexibly linked to the SMP domain. [[cite:PUB00075878], [cite:PUB00148191], [cite:PUB00148192], [cite:PUB00148193], [cite:PUB00148197], [cite:PUB00148194], [cite:PUB00145852], [cite:PUB00148195], [cite:PUB00148196], [cite:PUB00093119], [cite:PUB00148190], [cite:PUB00087567], [cite:PUB00146909], [cite:PUB00146903], [cite:PUB00146904], [cite:PUB00146905], [cite:PUB00146906], [cite:PUB00060834], [cite:PUB00111794], [cite:PUB00146907], [cite:PUB00146908], [cite:PUB00092089]]</p>",
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"title": "E-syt1 Re-arranges STIM1 Clusters to Stabilize Ring-shaped ER-PM Contact Sites and Accelerate Ca<sup>2+</sup> Store Replenishment.",
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"Kang F",
"Zhou M",
"Huang X",
"Fan J",
"Wei L",
"Boulanger J",
"Liu Z",
"Salamero J",
"Liu Y",
"Chen L."
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"Besprozvannaya M",
"Dickson E",
"Li H",
"Ginburg KS",
"Bers DM",
"Auwerx J",
"Nunnari J."
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"Mayya V",
"Lundgren DH",
"Hwang SI",
"Rezaul K",
"Wu L",
"Eng JK",
"Rodionov V",
"Han DK."
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"Lerias JR",
"Pinto MC",
"Botelho HM",
"Awatade NT",
"Quaresma MC",
"Silva IAL",
"Wanitchakool P",
"Schreiber R",
"Pepperkok R",
"Kunzelmann K",
"Amaral MD."
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"authors": [
"Nakajima D",
"Okazaki N",
"Yamakawa H",
"Kikuno R",
"Ohara O",
"Nagase T."
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"title": "Structure of a lipid-bound extended synaptotagmin indicates a role in lipid transfer.",
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"authors": [
"Schauder CM",
"Wu X",
"Saheki Y",
"Narayanaswamy P",
"Torta F",
"Wenk MR",
"De Camilli P",
"Reinisch KM."
],
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"title": "Extended Synaptotagmin (ESyt) Triple Knock-Out Mice Are Viable and Fertile without Obvious Endoplasmic Reticulum Dysfunction.",
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"medline_journal": "PLoS One",
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"authors": [
"Sclip A",
"Bacaj T",
"Giam LR",
"Sudhof TC."
],
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"medline_journal": "J Proteome Res",
"ISO_journal": "J Proteome Res",
"authors": [
"Yu LR",
"Zhu Z",
"Chan KC",
"Issaq HJ",
"Dimitrov DS",
"Veenstra TD."
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"issue": "4",
"year": 2019,
"title": "Feedback regulation of insulin secretion by extended synaptotagmin-1.",
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"authors": [
"Xie B",
"Nguyen PM",
"Idevall-Hagren O."
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"title": "Aster Proteins Facilitate Nonvesicular Plasma Membrane to ER Cholesterol Transport in Mammalian Cells.",
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"medline_journal": "Cell",
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"authors": [
"Sandhu J",
"Li S",
"Fairall L",
"Pfisterer SG",
"Gurnett JE",
"Xiao X",
"Weston TA",
"Vashi D",
"Ferrari A",
"Orozco JL",
"Hartman CL",
"Strugatsky D",
"Lee SD",
"He C",
"Hong C",
"Jiang H",
"Bentolila LA",
"Gatta AT",
"Levine TP",
"Ferng A",
"Lee R",
"Ford DA",
"Young SG",
"Ikonen E",
"Schwabe JWR",
"Tontonoz P."
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"issue": "3",
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"title": "Extended-synaptotagmin-2 mediates FGF receptor endocytosis and ERK activation in vivo.",
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"medline_journal": "Dev Cell",
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"authors": [
"Jean S",
"Mikryukov A",
"Tremblay MG",
"Baril J",
"Guillou F",
"Bellenfant S",
"Moss T."
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"title": "Control of plasma membrane lipid homeostasis by the extended synaptotagmins.",
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"medline_journal": "Nat Cell Biol",
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"authors": [
"Saheki Y",
"Bian X",
"Schauder CM",
"Sawaki Y",
"Surma MA",
"Klose C",
"Pincet F",
"Reinisch KM",
"De Camilli P."
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"medline_journal": "Cell Rep",
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"authors": [
"Chang CL",
"Hsieh TS",
"Yang TT",
"Rothberg KG",
"Azizoglu DB",
"Volk E",
"Liao JC",
"Liou J."
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"authors": [
"Xu J",
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"Zhou A",
"Tomchick DR",
"Sudhof TC",
"Rizo J."
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"medline_journal": "Mol Cell",
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"Daub H",
"Olsen JV",
"Bairlein M",
"Gnad F",
"Oppermann FS",
"Korner R",
"Greff Z",
"Keri G",
"Stemmann O",
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"title": "PI(4,5)P(2)-dependent and Ca(2+)-regulated ER-PM interactions mediated by the extended synaptotagmins.",
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"medline_journal": "Cell",
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"authors": [
"Giordano F",
"Saheki Y",
"Idevall-Hagren O",
"Colombo SF",
"Pirruccello M",
"Milosevic I",
"Gracheva EO",
"Bagriantsev SN",
"Borgese N",
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"title": "Extended Synaptotagmin 1 Interacts with Herpes Simplex Virus 1 Glycoprotein M and Negatively Modulates Virus-Induced Membrane Fusion. ",
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"medline_journal": "J Virol",
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"authors": [
"El Kasmi I",
"Khadivjam B",
"Lackman M",
"Duron J",
"Bonneil E",
"Thibault P",
"Lippe R."
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"De Camilli P."
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