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"name": "protein kinase C conserved region 1 (C1 domain) found in Rho-associated coiled-coil containing protein kinase 2 (ROCK2) and similar proteins",
"short": "C1_ROCK2"
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{
"text": "<p>ROCK2 is a serine/threonine kinase, catalyzing the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. ROCK2, also called Rho-associated protein kinase 2, Rho kinase 2, Rho-associated, coiled-coil-containing protein kinase II (ROCK-II), or p164 ROCK-2, was the first identified target of activated RhoA, and was found to play a role in stress fiber and focal adhesion formation. It is prominently expressed in the brain, heart, and skeletal muscles. It is implicated in vascular and neurological disorders, such as hypertension and vasospasm of the coronary and cerebral arteries. ROCK2 is also activated by caspase-2 cleavage, resulting in thrombin-induced microparticle generation in response to cell activation. Mice deficient in ROCK2 show intrauterine growth retardation and embryonic lethality because of placental dysfunction. ROCK proteins contain an N-terminal extension, a catalytic kinase domain, and a C-terminal extension, which contains a coiled-coil region encompassing a Rho-binding domain (RBD), a pleckstrin homology (PH) domain and a C1 domain. The C1 domain is a cysteine-rich zinc binding domain that does not bind DNA nor possess structural similarity to conventional zinc finger domains; it contains two separate Zn(2+)-binding sites. [[cite:PUB00112531], [cite:PUB00112532], [cite:PUB00119184], [cite:PUB00113039], [cite:PUB00119185], [cite:PUB00119186], [cite:PUB00119187], [cite:PUB00119188], [cite:PUB00119189], [cite:PUB00119190], [cite:PUB00119191], [cite:PUB00119192], [cite:PUB00119193], [cite:PUB00119194], [cite:PUB00035008], [cite:PUB00119195], [cite:PUB00040513]]</p>",
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"title": "Rho GTPase/Rho kinase inhibition as a novel target for the treatment of glaucoma.",
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"medline_journal": "BioDrugs",
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"Rao VP",
"Epstein DL."
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"issue": "3",
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"title": "Progress of the study of rho-kinase and future perspective of the inhibitor.",
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"medline_journal": "Yakugaku Zasshi",
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"Tawara S",
"Shimokawa H."
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"authors": [
"Mueller BK",
"Mack H",
"Teusch N."
],
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"title": "Rho kinase in the regulation of cell death and survival.",
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"medline_journal": "Arch Immunol Ther Exp (Warsz)",
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"authors": [
"Shi J",
"Wei L."
],
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"issue": "6",
"year": 2007,
"title": "Development of Rho-kinase inhibitors for cardiovascular medicine.",
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"raw_pages": "296-302",
"medline_journal": "Trends Pharmacol Sci",
"ISO_journal": "Trends Pharmacol Sci",
"authors": [
"Shimokawa H",
"Rashid M."
],
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"volume": "110",
"issue": "2",
"year": 2006,
"title": "RhoA/Rho-kinase in erectile tissue: mechanisms of disease and therapeutic insights.",
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"raw_pages": "153-65",
"medline_journal": "Clin Sci (Lond)",
"ISO_journal": "Clin Sci (Lond)",
"authors": [
"Jin L",
"Burnett AL."
],
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"volume": "15",
"issue": "2",
"year": 2003,
"title": "The ups and downs of Rho-kinase and penile erection: upstream regulators and downstream substrates of rho-kinase and their potential role in the erectile response.",
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"medline_journal": "Int J Impot Res",
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"authors": [
"Chitaley K",
"Webb RC",
"Mills TM."
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"title": "Development of specific Rho-kinase inhibitors and their clinical application.",
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"medline_journal": "Biochim Biophys Acta",
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"Tamura M",
"Nakao H",
"Yoshizaki H",
"Shiratsuchi M",
"Shigyo H",
"Yamada H",
"Ozawa T",
"Totsuka J",
"Hidaka H."
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"year": 2006,
"title": "Rho-kinase as a drug target for the treatment of airway hyperrespon-siveness in asthma.",
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"raw_pages": "339-48",
"medline_journal": "Mini Rev Med Chem",
"ISO_journal": "Mini Rev Med Chem",
"authors": [
"Gosens R",
"Schaafsma D",
"Nelemans SA",
"Halayko AJ."
],
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"issue": "10",
"year": 2005,
"title": "Rho/Rho kinase as a potential target for the treatment of renal disease.",
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"medline_journal": "Drug News Perspect",
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"authors": [
"Wakino S",
"Kanda T",
"Hayashi K."
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"year": 2006,
"title": "Rho kinase: a target for treating urinary bladder dysfunction?",
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"medline_journal": "Trends Pharmacol Sci",
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"authors": [
"Peters SL",
"Schmidt M",
"Michel MC."
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"title": "RhoA/Rho-kinase pathway: much more than just a modulation of vascular tone. Evidence from studies in humans.",
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"medline_journal": "J Hypertens",
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"authors": [
"Calo LA",
"Pessina AC."
],
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"title": "Recent evidence for an involvement of rho-kinase in cerebral vascular disease.",
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"medline_journal": "Stroke",
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"authors": [
"Chrissobolis S",
"Sobey CG."
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"medline_journal": "Structure",
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"authors": [
"Yamaguchi H",
"Kasa M",
"Amano M",
"Kaibuchi K",
"Hakoshima T."
],
"DOI_URL": "http://dx.doi.org/10.1016/j.str.2005.11.024"
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"title": "Dependence of proliferating dedifferentiated vascular smooth muscle contraction on Rho-Rho kinase system.",
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"raw_pages": "124-8",
"medline_journal": "Trends Cardiovasc Med",
"ISO_journal": "Trends Cardiovasc Med",
"authors": [
"Nishimura J",
"Bi D",
"Kanaide H."
],
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"title": "Vascular rho kinases and their potential therapeutic applications.",
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"medline_journal": "Curr Opin Drug Discov Devel",
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"authors": [
"Budzyn K",
"Sobey CG."
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"title": "Rho/Rho-kinase and C-reactive protein relationship in hypertension and atherosclerosis.",
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"medline_journal": "Nephrol Dial Transplant",
"ISO_journal": "Nephrol Dial Transplant",
"authors": [
"Calo LA",
"Pagnin E",
"Mussap M",
"Davis PA",
"Semplicini A."
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