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{
    "metadata": {
        "accession": "cd20498",
        "entry_id": null,
        "type": "domain",
        "go_terms": null,
        "source_database": "cdd",
        "member_databases": null,
        "integrated": null,
        "hierarchy": null,
        "name": {
            "name": "peptidase C58 domain of the YopT subfamily, including Yersinia pestis YopT and related proteins",
            "short": "C58_YopT"
        },
        "description": [
            {
                "text": "<p>This subfamily includes the plague organism Yersinia pestis cysteine protease YopT, an outer membrane protein. Y. pestis can disarm the host immune response by interfering with cell-signaling pathways; YopT cleaves post-translationally modified Rho GTPases near their carboxyl termini, releasing them from the membrane. This leads to the disruption of the actin cytoskeleton in host cells. YopT's proteolytic activity is dependent upon the invariant C/H/D residues conserved in the C58/YopT family peptidase domain. [[cite:PUB00009736], [cite:PUB00111659]]</p>",
                "llm": false,
                "checked": false,
                "updated": false
            }
        ],
        "wikipedia": null,
        "literature": {
            "PUB00111659": {
                "PMID": 19346252,
                "ISBN": null,
                "volume": "284",
                "issue": "23",
                "year": 2009,
                "title": "A family of bacterial cysteine protease type III effectors utilizes acylation-dependent and -independent strategies to localize to plasma membranes.",
                "URL": null,
                "raw_pages": "15867-79",
                "medline_journal": "J Biol Chem",
                "ISO_journal": "J Biol Chem",
                "authors": [
                    "Dowen RH",
                    "Engel JL",
                    "Shao F",
                    "Ecker JR",
                    "Dixon JE."
                ],
                "DOI_URL": null
            },
            "PUB00009736": {
                "PMID": 12062101,
                "ISBN": null,
                "volume": "109",
                "issue": "5",
                "year": 2002,
                "title": "A Yersinia effector and a Pseudomonas avirulence protein define a family of cysteine proteases functioning in bacterial pathogenesis.",
                "URL": null,
                "raw_pages": "575-88",
                "medline_journal": "Cell",
                "ISO_journal": "Cell",
                "authors": [
                    "Shao F",
                    "Merritt PM",
                    "Bao Z",
                    "Innes RW",
                    "Dixon JE."
                ],
                "DOI_URL": "http://dx.doi.org/10.1016/S0092-8674(02)00766-3"
            }
        },
        "set_info": {
            "accession": "cl41758",
            "name": "peptidase_C58-like"
        },
        "overlaps_with": null,
        "counters": {
            "subfamilies": 0,
            "domain_architectures": 0,
            "interactions": 0,
            "matches": 113,
            "pathways": 0,
            "proteins": 113,
            "proteomes": 45,
            "sets": 1,
            "structural_models": {
                "alphafold": 60,
                "bfvd": 0
            },
            "structures": 1,
            "taxa": 148
        },
        "entry_annotations": {},
        "cross_references": {},
        "is_llm": false,
        "is_reviewed_llm": false,
        "is_updated_llm": false,
        "representative_structure": null
    }
}