{"metadata":{"accession":"cd20272","entry_id":null,"type":"domain","go_terms":null,"source_database":"cdd","member_databases":null,"integrated":"IPR045300","hierarchy":null,"name":{"name":"LYR (leucine-tyrosine-arginine) motif found in mitochondrial elongation factor 1 microprotein (MIEF1-MP) and similar proteins","short":"Complex1_LYR_MIEF1-MP"},"description":[{"text":"<p>MIEF1-MP, also called alternative mitochondrial elongation factor 1 (MIEF1) protein (AltMIEF1), or MIEF1 upstream open reading frame protein, is involved in the regulation of mitochondrial fission mediated by dynamin-1-like protein (DNM1L). It positively regulates mitochondrial translation. MIEF1-MP belongs to the Complex1_LYR-like superfamily that consists of proteins of diverse functions that are exclusively found in eukaryotes and contain the conserved tripeptide 'LYR' close to the N-terminus. [[cite:PUB00108404], [cite:PUB00098503], [cite:PUB00095404]]</p>","llm":false,"checked":false,"updated":false}],"wikipedia":null,"literature":{"PUB00095404":{"PMID":24059529,"ISBN":null,"volume":"41","issue":"5","year":2013,"title":"The superfamily of mitochondrial Complex1_LYR motif-containing (LYRM) proteins.","URL":null,"raw_pages":"1335-41","medline_journal":"Biochem Soc Trans","ISO_journal":"Biochem. Soc. Trans.","authors":["Angerer H."],"DOI_URL":null},"PUB00098503":{"PMID":30215512,"ISBN":null,"volume":"57","issue":"38","year":2018,"title":"MIEF1 Microprotein Regulates Mitochondrial Translation.","URL":null,"raw_pages":"5564-5575","medline_journal":"Biochemistry","ISO_journal":"Biochemistry","authors":["Rathore A","Chu Q","Tan D","Martinez TF","Donaldson CJ","Diedrich JK","Yates JR 3rd","Saghatelian A."],"DOI_URL":null},"PUB00108404":{"PMID":29083303,"ISBN":null,"volume":"6","issue":null,"year":2017,"title":"Deep transcriptome annotation enables the discovery and functional characterization of cryptic small proteins. ","URL":null,"raw_pages":"e27860","medline_journal":"Elife","ISO_journal":"Elife","authors":["Samandi S","Roy AV","Delcourt V","Lucier JF","Gagnon J","Beaudoin MC","Vanderperre B","Breton MA","Motard J","Jacques JF","Brunelle M","Gagnon-Arsenault I","Fournier I","Ouangraoua A","Hunting DJ","Cohen AA","Landry CR","Scott MS","Roucou X."],"DOI_URL":null}},"set_info":{"accession":"cl40429","name":"Complex1_LYR_SF"},"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":0,"interactions":0,"matches":455,"pathways":0,"proteins":455,"proteomes":402,"sets":1,"structural_models":{"alphafold":407,"bfvd":0},"structures":36,"taxa":1578},"entry_annotations":{},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}