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{
"metadata": {
"accession": "cd20272",
"entry_id": null,
"type": "domain",
"go_terms": null,
"source_database": "cdd",
"member_databases": null,
"integrated": "IPR045300",
"hierarchy": null,
"name": {
"name": "LYR (leucine-tyrosine-arginine) motif found in mitochondrial elongation factor 1 microprotein (MIEF1-MP) and similar proteins",
"short": "Complex1_LYR_MIEF1-MP"
},
"description": [
{
"text": "<p>MIEF1-MP, also called alternative mitochondrial elongation factor 1 (MIEF1) protein (AltMIEF1), or MIEF1 upstream open reading frame protein, is involved in the regulation of mitochondrial fission mediated by dynamin-1-like protein (DNM1L). It positively regulates mitochondrial translation. MIEF1-MP belongs to the Complex1_LYR-like superfamily that consists of proteins of diverse functions that are exclusively found in eukaryotes and contain the conserved tripeptide 'LYR' close to the N-terminus. [[cite:PUB00108404], [cite:PUB00098503], [cite:PUB00095404]]</p>",
"llm": false,
"checked": false,
"updated": false
}
],
"wikipedia": null,
"literature": {
"PUB00095404": {
"PMID": 24059529,
"ISBN": null,
"volume": "41",
"issue": "5",
"year": 2013,
"title": "The superfamily of mitochondrial Complex1_LYR motif-containing (LYRM) proteins.",
"URL": null,
"raw_pages": "1335-41",
"medline_journal": "Biochem Soc Trans",
"ISO_journal": "Biochem. Soc. Trans.",
"authors": [
"Angerer H."
],
"DOI_URL": null
},
"PUB00098503": {
"PMID": 30215512,
"ISBN": null,
"volume": "57",
"issue": "38",
"year": 2018,
"title": "MIEF1 Microprotein Regulates Mitochondrial Translation.",
"URL": null,
"raw_pages": "5564-5575",
"medline_journal": "Biochemistry",
"ISO_journal": "Biochemistry",
"authors": [
"Rathore A",
"Chu Q",
"Tan D",
"Martinez TF",
"Donaldson CJ",
"Diedrich JK",
"Yates JR 3rd",
"Saghatelian A."
],
"DOI_URL": null
},
"PUB00108404": {
"PMID": 29083303,
"ISBN": null,
"volume": "6",
"issue": null,
"year": 2017,
"title": "Deep transcriptome annotation enables the discovery and functional characterization of cryptic small proteins. ",
"URL": null,
"raw_pages": "e27860",
"medline_journal": "Elife",
"ISO_journal": "Elife",
"authors": [
"Samandi S",
"Roy AV",
"Delcourt V",
"Lucier JF",
"Gagnon J",
"Beaudoin MC",
"Vanderperre B",
"Breton MA",
"Motard J",
"Jacques JF",
"Brunelle M",
"Gagnon-Arsenault I",
"Fournier I",
"Ouangraoua A",
"Hunting DJ",
"Cohen AA",
"Landry CR",
"Scott MS",
"Roucou X."
],
"DOI_URL": null
}
},
"set_info": {
"accession": "cl40429",
"name": "Complex1_LYR_SF"
},
"overlaps_with": null,
"counters": {
"subfamilies": 0,
"domain_architectures": 0,
"interactions": 0,
"matches": 455,
"pathways": 0,
"proteins": 455,
"proteomes": 402,
"sets": 1,
"structural_models": {
"alphafold": 407,
"bfvd": 0
},
"structures": 36,
"taxa": 1578
},
"entry_annotations": {},
"cross_references": {},
"is_llm": false,
"is_reviewed_llm": false,
"is_updated_llm": false,
"representative_structure": null
}
}
