{"metadata":{"accession":"cd17010","entry_id":null,"type":"domain","go_terms":null,"source_database":"cdd","member_databases":null,"integrated":null,"hierarchy":null,"name":{"name":"VHS (Vps27/Hrs/STAM) domain of ADP-ribosylation factor-binding protein GGA2","short":"VHS_GGA2"},"description":[{"text":"<p>ADP-ribosylation factor-binding protein GGA2 (Golgi-localized, Gamma-ear-containing, Arf-binding 2) is also called Gamma-adaptin-related protein 2 and VHS domain and ear domain of gamma-adaptin (Vear). It is a member of the GGA subfamily, which is comprised of ubiquitously expressed, monomeric, motif-binding cargo/clathrin adaptor proteins involved in membrane trafficking between the Trans-Golgi Network (TGN) and endosomes. The VHS domain has a superhelical structure similar to the structure of the ARM (Armadillo) repeats and is present at the N-termini of proteins. GGA proteins have a multidomain structure consisting of an N-terminal VHS domain linked by a short proline-rich linker to a GAT (GGA and TOM) domain, which is followed by a long flexible linker to the C-terminal appendage, GAE (Gamma-Adaptin Ear) domain. The VHS domain of GGA proteins binds to the acidic-cluster dileucine (DxxLL) motif found on the cytoplasmic tails of cargo proteins trafficked between the Trans-Golgi Network and the endosomal system. [[cite:PUB00007169], [cite:PUB00113750], [cite:PUB00018178], [cite:PUB00031796], [cite:PUB00030034], [cite:PUB00021946], [cite:PUB00027011], [cite:PUB00027345], [cite:PUB00101580]]</p>","llm":false,"checked":false,"updated":false}],"wikipedia":null,"literature":{"PUB00101580":{"PMID":20015111,"ISBN":null,"volume":"11","issue":"2","year":2010,"title":"GGA autoinhibition revisited.","URL":null,"raw_pages":"259-73","medline_journal":"Traffic","ISO_journal":"Traffic","authors":["Cramer JF","Gustafsen C","Behrens MA","Oliveira CL","Pedersen JS","Madsen P","Petersen CM","Thirup SS."],"DOI_URL":null},"PUB00027011":{"PMID":12032548,"ISBN":null,"volume":"9","issue":"7","year":2002,"title":"Phosphoregulation of sorting signal-VHS domain interactions by a direct electrostatic mechanism.","URL":null,"raw_pages":"532-6","medline_journal":"Nat Struct Biol","ISO_journal":"Nat. Struct. Biol.","authors":["Kato Y","Misra S","Puertollano R","Hurley JH","Bonifacino JS."],"DOI_URL":null},"PUB00113750":{"PMID":12651740,"ISBN":null,"volume":"72","issue":null,"year":2003,"title":"Signals for sorting of transmembrane proteins to endosomes and lysosomes.","URL":null,"raw_pages":"395-447","medline_journal":"Annu Rev Biochem","ISO_journal":"Annu Rev Biochem","authors":["Bonifacino JS","Traub LM."],"DOI_URL":null},"PUB00030034":{"PMID":14567678,"ISBN":null,"volume":"42","issue":"42","year":2003,"title":"Biochemical and structural characterization of the interaction of memapsin 2 (beta-secretase) cytosolic domain with the VHS domain of GGA proteins.","URL":null,"raw_pages":"12174-80","medline_journal":"Biochemistry","ISO_journal":"Biochemistry","authors":["He X","Zhu G","Koelsch G","Rodgers KK","Zhang XC","Tang J."],"DOI_URL":"http://dx.doi.org/10.1021/bi035199h"},"PUB00027345":{"PMID":12606052,"ISBN":null,"volume":"537","issue":"1-3","year":2003,"title":"Crystal structure of GGA2 VHS domain and its implication in plasticity in the ligand binding pocket.","URL":null,"raw_pages":"171-6","medline_journal":"FEBS Lett","ISO_journal":"FEBS Lett.","authors":["Zhu G","He X","Zhai P","Terzyan S","Tang J","Zhang XC."],"DOI_URL":"http://dx.doi.org/10.1016/S0014-5793(03)00095-4"},"PUB00021946":{"PMID":11859375,"ISBN":null,"volume":"415","issue":"6874","year":2002,"title":"Structural basis for acidic-cluster-dileucine sorting-signal recognition by VHS domains.","URL":null,"raw_pages":"933-7","medline_journal":"Nature","ISO_journal":"Nature","authors":["Misra S","Puertollano R","Kato Y","Bonifacino JS","Hurley JH."],"DOI_URL":"http://dx.doi.org/10.1038/415933a"},"PUB00018178":{"PMID":9872381,"ISBN":null,"volume":"440","issue":"3","year":1998,"title":"VHS domain marks a group of proteins involved in endocytosis and vesicular trafficking.","URL":null,"raw_pages":"255-7","medline_journal":"FEBS Lett","ISO_journal":"FEBS Lett.","authors":["Lohi O","Lehto VP."],"DOI_URL":"http://dx.doi.org/10.1016/S0014-5793(98)01401-X"},"PUB00031796":{"PMID":15117318,"ISBN":null,"volume":"5","issue":"6","year":2004,"title":"Insights into the phosphoregulation of beta-secretase sorting signal by the VHS domain of GGA1.","URL":null,"raw_pages":"437-48","medline_journal":"Traffic","ISO_journal":"Traffic","authors":["Shiba T","Kametaka S","Kawasaki M","Shibata M","Waguri S","Uchiyama Y","Wakatsuki S."],"DOI_URL":"http://dx.doi.org/10.1111/j.1600-0854.2004.00188.x"},"PUB00007169":{"PMID":11911875,"ISBN":null,"volume":"513","issue":"1","year":2002,"title":"VHS domain -- a longshoreman of vesicle lines.","URL":null,"raw_pages":"19-23","medline_journal":"FEBS Lett","ISO_journal":"FEBS Lett.","authors":["Lohi O","Poussu A","Mao Y","Quiocho F","Lehto VP."],"DOI_URL":"http://dx.doi.org/10.1016/S0014-5793(01)03287-2"}},"set_info":{"accession":"cl02544","name":"VHS_ENTH_ANTH"},"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":0,"interactions":0,"matches":238,"pathways":0,"proteins":238,"proteomes":148,"sets":1,"structural_models":{"alphafold":215,"bfvd":0},"structures":0,"taxa":513},"entry_annotations":{},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}