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{
"metadata": {
"accession": "cd17010",
"entry_id": null,
"type": "domain",
"go_terms": null,
"source_database": "cdd",
"member_databases": null,
"integrated": null,
"hierarchy": null,
"name": {
"name": "VHS (Vps27/Hrs/STAM) domain of ADP-ribosylation factor-binding protein GGA2",
"short": "VHS_GGA2"
},
"description": [
{
"text": "<p>ADP-ribosylation factor-binding protein GGA2 (Golgi-localized, Gamma-ear-containing, Arf-binding 2) is also called Gamma-adaptin-related protein 2 and VHS domain and ear domain of gamma-adaptin (Vear). It is a member of the GGA subfamily, which is comprised of ubiquitously expressed, monomeric, motif-binding cargo/clathrin adaptor proteins involved in membrane trafficking between the Trans-Golgi Network (TGN) and endosomes. The VHS domain has a superhelical structure similar to the structure of the ARM (Armadillo) repeats and is present at the N-termini of proteins. GGA proteins have a multidomain structure consisting of an N-terminal VHS domain linked by a short proline-rich linker to a GAT (GGA and TOM) domain, which is followed by a long flexible linker to the C-terminal appendage, GAE (Gamma-Adaptin Ear) domain. The VHS domain of GGA proteins binds to the acidic-cluster dileucine (DxxLL) motif found on the cytoplasmic tails of cargo proteins trafficked between the Trans-Golgi Network and the endosomal system. [[cite:PUB00007169], [cite:PUB00113750], [cite:PUB00018178], [cite:PUB00031796], [cite:PUB00030034], [cite:PUB00021946], [cite:PUB00027011], [cite:PUB00027345], [cite:PUB00101580]]</p>",
"llm": false,
"checked": false,
"updated": false
}
],
"wikipedia": null,
"literature": {
"PUB00101580": {
"PMID": 20015111,
"ISBN": null,
"volume": "11",
"issue": "2",
"year": 2010,
"title": "GGA autoinhibition revisited.",
"URL": null,
"raw_pages": "259-73",
"medline_journal": "Traffic",
"ISO_journal": "Traffic",
"authors": [
"Cramer JF",
"Gustafsen C",
"Behrens MA",
"Oliveira CL",
"Pedersen JS",
"Madsen P",
"Petersen CM",
"Thirup SS."
],
"DOI_URL": null
},
"PUB00027011": {
"PMID": 12032548,
"ISBN": null,
"volume": "9",
"issue": "7",
"year": 2002,
"title": "Phosphoregulation of sorting signal-VHS domain interactions by a direct electrostatic mechanism.",
"URL": null,
"raw_pages": "532-6",
"medline_journal": "Nat Struct Biol",
"ISO_journal": "Nat. Struct. Biol.",
"authors": [
"Kato Y",
"Misra S",
"Puertollano R",
"Hurley JH",
"Bonifacino JS."
],
"DOI_URL": null
},
"PUB00113750": {
"PMID": 12651740,
"ISBN": null,
"volume": "72",
"issue": null,
"year": 2003,
"title": "Signals for sorting of transmembrane proteins to endosomes and lysosomes.",
"URL": null,
"raw_pages": "395-447",
"medline_journal": "Annu Rev Biochem",
"ISO_journal": "Annu Rev Biochem",
"authors": [
"Bonifacino JS",
"Traub LM."
],
"DOI_URL": null
},
"PUB00030034": {
"PMID": 14567678,
"ISBN": null,
"volume": "42",
"issue": "42",
"year": 2003,
"title": "Biochemical and structural characterization of the interaction of memapsin 2 (beta-secretase) cytosolic domain with the VHS domain of GGA proteins.",
"URL": null,
"raw_pages": "12174-80",
"medline_journal": "Biochemistry",
"ISO_journal": "Biochemistry",
"authors": [
"He X",
"Zhu G",
"Koelsch G",
"Rodgers KK",
"Zhang XC",
"Tang J."
],
"DOI_URL": "http://dx.doi.org/10.1021/bi035199h"
},
"PUB00027345": {
"PMID": 12606052,
"ISBN": null,
"volume": "537",
"issue": "1-3",
"year": 2003,
"title": "Crystal structure of GGA2 VHS domain and its implication in plasticity in the ligand binding pocket.",
"URL": null,
"raw_pages": "171-6",
"medline_journal": "FEBS Lett",
"ISO_journal": "FEBS Lett.",
"authors": [
"Zhu G",
"He X",
"Zhai P",
"Terzyan S",
"Tang J",
"Zhang XC."
],
"DOI_URL": "http://dx.doi.org/10.1016/S0014-5793(03)00095-4"
},
"PUB00021946": {
"PMID": 11859375,
"ISBN": null,
"volume": "415",
"issue": "6874",
"year": 2002,
"title": "Structural basis for acidic-cluster-dileucine sorting-signal recognition by VHS domains.",
"URL": null,
"raw_pages": "933-7",
"medline_journal": "Nature",
"ISO_journal": "Nature",
"authors": [
"Misra S",
"Puertollano R",
"Kato Y",
"Bonifacino JS",
"Hurley JH."
],
"DOI_URL": "http://dx.doi.org/10.1038/415933a"
},
"PUB00018178": {
"PMID": 9872381,
"ISBN": null,
"volume": "440",
"issue": "3",
"year": 1998,
"title": "VHS domain marks a group of proteins involved in endocytosis and vesicular trafficking.",
"URL": null,
"raw_pages": "255-7",
"medline_journal": "FEBS Lett",
"ISO_journal": "FEBS Lett.",
"authors": [
"Lohi O",
"Lehto VP."
],
"DOI_URL": "http://dx.doi.org/10.1016/S0014-5793(98)01401-X"
},
"PUB00031796": {
"PMID": 15117318,
"ISBN": null,
"volume": "5",
"issue": "6",
"year": 2004,
"title": "Insights into the phosphoregulation of beta-secretase sorting signal by the VHS domain of GGA1.",
"URL": null,
"raw_pages": "437-48",
"medline_journal": "Traffic",
"ISO_journal": "Traffic",
"authors": [
"Shiba T",
"Kametaka S",
"Kawasaki M",
"Shibata M",
"Waguri S",
"Uchiyama Y",
"Wakatsuki S."
],
"DOI_URL": "http://dx.doi.org/10.1111/j.1600-0854.2004.00188.x"
},
"PUB00007169": {
"PMID": 11911875,
"ISBN": null,
"volume": "513",
"issue": "1",
"year": 2002,
"title": "VHS domain -- a longshoreman of vesicle lines.",
"URL": null,
"raw_pages": "19-23",
"medline_journal": "FEBS Lett",
"ISO_journal": "FEBS Lett.",
"authors": [
"Lohi O",
"Poussu A",
"Mao Y",
"Quiocho F",
"Lehto VP."
],
"DOI_URL": "http://dx.doi.org/10.1016/S0014-5793(01)03287-2"
}
},
"set_info": {
"accession": "cl02544",
"name": "VHS_ENTH_ANTH"
},
"overlaps_with": null,
"counters": {
"subfamilies": 0,
"domain_architectures": 0,
"interactions": 0,
"matches": 238,
"pathways": 0,
"proteins": 238,
"proteomes": 148,
"sets": 1,
"structural_models": {
"alphafold": 215,
"bfvd": 0
},
"structures": 0,
"taxa": 513
},
"entry_annotations": {},
"cross_references": {},
"is_llm": false,
"is_reviewed_llm": false,
"is_updated_llm": false,
"representative_structure": null
}
}
