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"name": "protein tyrosine phosphatase-like domain of myotubularin related phosphoinositide phosphatase 2",
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"text": "<p>Myotubularin related phosphoinositide phosphatase 2 (MTMR2) is enzymatically active and contains an additional N-terminal PH-GRAM domain and C-terminal coiled-coiled domain and PDZ binding site. Mutations in MTMR2 causes Charcot-Marie-Tooth type 4B1, a severe childhood-onset neuromuscular disorder, characterized by demyelination and redundant loops of myelin known as myelin outfoldings, a similar phenotype as mutations in MTMR13. MTMR13, an inactive phosphatase, is believed to interact with MTMR2 and stimulate its phosphatase activity. In general, myotubularins are a unique subgroup of protein tyrosine phosphatases that use inositol phospholipids, rather than phosphoproteins, as substrates. They dephosphorylate the D-3 position of phosphatidylinositol 3-phosphate [PI(3)P] and phosphatidylinositol 3,5-bisphosphate [PI(3,5)P2], generating phosphatidylinositol and phosphatidylinositol 5-phosphate [PI(5)P], respectively. [[cite:PUB00144806], [cite:PUB00142739], [cite:PUB00144807], [cite:PUB00144808], [cite:PUB00144809], [cite:PUB00141651], [cite:PUB00039007], [cite:PUB00144810], [cite:PUB00073215], [cite:PUB00086395], [cite:PUB00138911], [cite:PUB00138912], [cite:PUB00073246], [cite:PUB00096302], [cite:PUB00056895], [cite:PUB00096300], [cite:PUB00138879], [cite:PUB00033631], [cite:PUB00138878], [cite:PUB00043723]]</p>",
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"issue": "36",
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"title": "The phosphoinositide-3-phosphatase MTMR2 associates with MTMR13, a membrane-associated pseudophosphatase also mutated in type 4B Charcot-Marie-Tooth disease.",
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"medline_journal": "J Biol Chem",
"ISO_journal": "J. Biol. Chem.",
"authors": [
"Robinson FL",
"Dixon JE."
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"title": "SOX10 regulates an alternative promoter at the Charcot-Marie-Tooth disease locus MTMR2.",
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"medline_journal": "Hum Mol Genet",
"ISO_journal": "Hum Mol Genet",
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"Fogarty EA",
"Brewer MH",
"Rodriguez-Molina JF",
"Law WD",
"Ma KH",
"Steinberg NM",
"Svaren J",
"Antonellis A."
],
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"volume": "63",
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"year": 2017,
"title": "WANTED - Dead or alive: Myotubularins, a large disease-associated protein family.",
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"medline_journal": "Adv Biol Regul",
"ISO_journal": "Adv Biol Regul",
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"Raess MA",
"Friant S",
"Cowling BS",
"Laporte J."
],
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"issue": "37",
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"title": "Loss of Mtmr2 phosphatase in Schwann cells but not in motor neurons causes Charcot-Marie-Tooth type 4B1 neuropathy with myelin outfoldings.",
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"medline_journal": "J Neurosci",
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"Bolis A",
"Coviello S",
"Bussini S",
"Dina G",
"Pardini C",
"Previtali SC",
"Malaguti M",
"Morana P",
"Del Carro U",
"Feltri ML",
"Quattrini A",
"Wrabetz L",
"Bolino A."
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"title": "Endosomal targeting of the phosphoinositide 3-phosphatase MTMR2 is regulated by an N-terminal phosphorylation site.",
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"medline_journal": "J Biol Chem",
"ISO_journal": "J Biol Chem",
"authors": [
"Franklin NE",
"Taylor GS",
"Vacratsis PO."
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"title": "The CMT4B disease-causing proteins MTMR2 and MTMR13/SBF2 regulate AKT signalling.",
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"medline_journal": "J Cell Mol Med",
"ISO_journal": "J Cell Mol Med",
"authors": [
"Berger P",
"Tersar K",
"Ballmer-Hofer K",
"Suter U."
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"Robinson FL",
"Dixon JE."
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"title": "Differential phosphorylation of the phosphoinositide 3-phosphatase MTMR2 regulates its association with early endosomal subtypes.",
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"medline_journal": "J Cell Sci",
"ISO_journal": "J Cell Sci",
"authors": [
"Franklin NE",
"Bonham CA",
"Xhabija B",
"Vacratsis PO."
],
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"title": "PTEN and myotubularin phosphatases: from 3-phosphoinositide dephosphorylation to disease.",
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"medline_journal": "Trends Cell Biol",
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"authors": [
"Wishart MJ",
"Dixon JE."
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"title": "Protein tyrosine phosphatases: from genes, to function, to disease.",
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"authors": [
"Tonks NK."
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"medline_journal": "Mol Neurobiol",
"ISO_journal": "Mol Neurobiol",
"authors": [
"Bolis A",
"Zordan P",
"Coviello S",
"Bolino A."
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"medline_journal": "Curr Opin Struct Biol",
"ISO_journal": "Curr. Opin. Struct. Biol.",
"authors": [
"Begley MJ",
"Dixon JE."
],
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"Ng AA",
"Logan AM",
"Schmidt EJ",
"Robinson FL."
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"title": "Molecular basis for substrate recognition by MTMR2, a myotubularin family phosphoinositide phosphatase.",
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"medline_journal": "Proc Natl Acad Sci U S A",
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"Begley MJ",
"Taylor GS",
"Brock MA",
"Ghosh P",
"Woods VL",
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"medline_journal": "Curr Top Microbiol Immunol",
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"Amoasii L",
"Hnia K",
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"Maehama T",
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"medline_journal": "Hum Mol Genet",
"ISO_journal": "Hum. Mol. Genet.",
"authors": [
"Laporte J",
"Bedez F",
"Bolino A",
"Mandel JL."
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"Alonso A",
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"authors": [
"Alonso A",
"Nunes-Xavier CE",
"Bayon Y",
"Pulido R."
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