{"metadata":{"accession":"cd14330","entry_id":null,"type":"domain","go_terms":null,"source_database":"cdd","member_databases":null,"integrated":null,"hierarchy":null,"name":{"name":"UBA domain found in Arabidopsis thaliana DNA (cytosine-5)-methyltransferase DRM2 (atDRM2) and similar proteins","short":"UBA_atDRM2_like"},"description":[{"text":"<p>atDRM2, also called protein domains rearranged methylase 2, is a homolog of the mammalian de novo methyltransferase DNMT3. It is the major de novo methyltransferase targeted to DNA by small interfering RNAs (siRNAs) in the RNA-directed DNA methylation (RdDM) pathway in Arabidopsis thaliana. atDRM2 is a part of the RdDM effector complex and plays a catalytic role in RdDM. It contains an N-terminal UBA domains and a C-terminal methyltransferase domain, both of which are required for normal RdDM. 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Biol.","authors":["Cao X","Aufsatz W","Zilberman D","Mette MF","Huang MS","Matzke M","Jacobsen SE."],"DOI_URL":"http://dx.doi.org/10.1016/j.cub.2003.11.052"},"PUB00089390":{"PMID":21811420,"ISBN":null,"volume":"7","issue":"7","year":2011,"title":"SHH1, a homeodomain protein required for DNA methylation, as well as RDR2, RDM4, and chromatin remodeling factors, associate with RNA polymerase IV.","URL":null,"raw_pages":"e1002195","medline_journal":"PLoS Genet","ISO_journal":"PLoS Genet.","authors":["Law JA","Vashisht AA","Wohlschlegel JA","Jacobsen SE."],"DOI_URL":"https://doi.org/10.1371/journal.pgen.1002195"},"PUB00057309":{"PMID":20410883,"ISBN":null,"volume":"465","issue":"7294","year":2010,"title":"An RNA polymerase II- and AGO4-associated protein acts in RNA-directed DNA methylation.","URL":null,"raw_pages":"106-9","medline_journal":"Nature","ISO_journal":"Nature","authors":["Gao Z","Liu HL","Daxinger L","Pontes O","He X","Qian W","Lin H","Xie M","Lorkovic ZJ","Zhang S","Miki D","Zhan X","Pontier D","Lagrange T","Jin H","Matzke AJ","Matzke M","Pikaard CS","Zhu JK."],"DOI_URL":"http://dx.doi.org/10.1038/nature09025"},"PUB00058139":{"PMID":12121623,"ISBN":null,"volume":"12","issue":"13","year":2002,"title":"Role of the arabidopsis DRM methyltransferases in de novo DNA methylation and gene silencing.","URL":null,"raw_pages":"1138-44","medline_journal":"Curr Biol","ISO_journal":"Curr. 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