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"name": {
"name": "UBA domain found in Arabidopsis thaliana DNA (cytosine-5)-methyltransferase DRM2 (atDRM2) and similar proteins",
"short": "UBA_atDRM2_like"
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{
"text": "<p>atDRM2, also called protein domains rearranged methylase 2, is a homolog of the mammalian de novo methyltransferase DNMT3. It is the major de novo methyltransferase targeted to DNA by small interfering RNAs (siRNAs) in the RNA-directed DNA methylation (RdDM) pathway in Arabidopsis thaliana. atDRM2 is a part of the RdDM effector complex and plays a catalytic role in RdDM. It contains an N-terminal UBA domains and a C-terminal methyltransferase domain, both of which are required for normal RdDM. [[cite:PUB00134020], [cite:PUB00058138], [cite:PUB00058139], [cite:PUB00058140], [cite:PUB00057309], [cite:PUB00089390], [cite:PUB00134021], [cite:PUB00096470], [cite:PUB00134022], [cite:PUB00109101], [cite:PUB00134023]]</p>",
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"title": "Role of the DRM and CMT3 methyltransferases in RNA-directed DNA methylation.",
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"medline_journal": "Curr Biol",
"ISO_journal": "Curr. Biol.",
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"Cao X",
"Aufsatz W",
"Zilberman D",
"Mette MF",
"Huang MS",
"Matzke M",
"Jacobsen SE."
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"title": "SHH1, a homeodomain protein required for DNA methylation, as well as RDR2, RDM4, and chromatin remodeling factors, associate with RNA polymerase IV.",
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"medline_journal": "PLoS Genet",
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"authors": [
"Law JA",
"Vashisht AA",
"Wohlschlegel JA",
"Jacobsen SE."
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"volume": "465",
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"title": "An RNA polymerase II- and AGO4-associated protein acts in RNA-directed DNA methylation.",
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"medline_journal": "Nature",
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"authors": [
"Gao Z",
"Liu HL",
"Daxinger L",
"Pontes O",
"He X",
"Qian W",
"Lin H",
"Xie M",
"Lorkovic ZJ",
"Zhang S",
"Miki D",
"Zhan X",
"Pontier D",
"Lagrange T",
"Jin H",
"Matzke AJ",
"Matzke M",
"Pikaard CS",
"Zhu JK."
],
"DOI_URL": "http://dx.doi.org/10.1038/nature09025"
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"volume": "12",
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"year": 2002,
"title": "Role of the arabidopsis DRM methyltransferases in de novo DNA methylation and gene silencing.",
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"raw_pages": "1138-44",
"medline_journal": "Curr Biol",
"ISO_journal": "Curr. Biol.",
"authors": [
"Cao X",
"Jacobsen SE."
],
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"title": "Conserved plant genes with similarity to mammalian de novo DNA methyltransferases.",
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"raw_pages": "4979-84",
"medline_journal": "Proc Natl Acad Sci U S A",
"ISO_journal": "Proc Natl Acad Sci U S A",
"authors": [
"Cao X",
"Springer NM",
"Muszynski MG",
"Phillips RL",
"Kaeppler S",
"Jacobsen SE."
],
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"PMID": 19043555,
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"volume": "4",
"issue": "11",
"year": 2008,
"title": "SRA-domain proteins required for DRM2-mediated de novo DNA methylation.",
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"raw_pages": "e1000280",
"medline_journal": "PLoS Genet",
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"authors": [
"Johnson LM",
"Law JA",
"Khattar A",
"Henderson IR",
"Jacobsen SE."
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"title": "Identification of genes required for de novo DNA methylation in Arabidopsis.",
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"medline_journal": "Epigenetics",
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"Greenberg MV",
"Ausin I",
"Chan SW",
"Cokus SJ",
"Cuperus JT",
"Feng S",
"Law JA",
"Chu C",
"Pellegrini M",
"Carrington JC",
"Jacobsen SE."
],
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"volume": "99 Suppl 4",
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"year": 2002,
"title": "Locus-specific control of asymmetric and CpNpG methylation by the DRM and CMT3 methyltransferase genes.",
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"raw_pages": "16491-8",
"medline_journal": "Proc Natl Acad Sci U S A",
"ISO_journal": "Proc. Natl. Acad. Sci. U.S.A.",
"authors": [
"Cao X",
"Jacobsen SE."
],
"DOI_URL": "http://dx.doi.org/10.1073/pnas.162371599"
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"volume": "20",
"issue": "10",
"year": 2010,
"title": "A protein complex required for polymerase V transcripts and RNA- directed DNA methylation in Arabidopsis.",
"URL": null,
"raw_pages": "951-6",
"medline_journal": "Curr Biol",
"ISO_journal": "Curr Biol",
"authors": [
"Law JA",
"Ausin I",
"Johnson LM",
"Vashisht AA",
"Zhu JK",
"Wohlschlegel JA",
"Jacobsen SE."
],
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},
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"PMID": 21060858,
"ISBN": null,
"volume": "6",
"issue": "10",
"year": 2010,
"title": "The de novo cytosine methyltransferase DRM2 requires intact UBA domains and a catalytically mutated paralog DRM3 during RNA-directed DNA methylation in Arabidopsis thaliana.",
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"raw_pages": "e1001182",
"medline_journal": "PLoS Genet",
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"authors": [
"Henderson IR",
"Deleris A",
"Wong W",
"Zhong X",
"Chin HG",
"Horwitz GA",
"Kelly KA",
"Pradhan S",
"Jacobsen SE."
],
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"year": 2011,
"title": "Genetic evidence that DNA methyltransferase DRM2 has a direct catalytic role in RNA-directed DNA methylation in Arabidopsis thaliana.",
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"raw_pages": "977-9",
"medline_journal": "Genetics",
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"authors": [
"Naumann U",
"Daxinger L",
"Kanno T",
"Eun C",
"Long Q",
"Lorkovic ZJ",
"Matzke M",
"Matzke AJ."
],
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}
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