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{
    "metadata": {
        "accession": "cd13838",
        "entry_id": null,
        "type": "domain",
        "go_terms": null,
        "source_database": "cdd",
        "member_databases": null,
        "integrated": "IPR021983",
        "hierarchy": null,
        "name": {
            "name": "Ribonuclease-like Prp8 domain IV core",
            "short": "RNase_H_like_Prp8_IV"
        },
        "description": [
            {
                "text": "<p>This family contains Prp8 domain IV, which adopts a RNase H like fold within its core structure but with little sequence similarity. Prp8, a spliceosome protein, interacts directly with the splice sites and branch regions of precursor-mRNAs and spliceosomal RNAs associated with catalysis of the two steps of splicing. Catalysis of RNA cleavage by RNase H-like proteins involves a two-metal mechanism in which adjacently-bound divalent magnesium ions promote hydrolysis by activation of a water nucleophile and stabilization of the transition-state. However, the Prp8 domain IV contains only one of the canonical metal-binding sites and the coordinating side chains are spatially conserved with respect to Mg2+-coordinating residues within the RNase H fold. [[cite:PUB00051743]]</p>",
                "llm": false,
                "checked": false,
                "updated": false
            }
        ],
        "wikipedia": null,
        "literature": {
            "PUB00051743": {
                "PMID": 18836455,
                "ISBN": null,
                "volume": "15",
                "issue": "11",
                "year": 2008,
                "title": "Structural elucidation of a PRP8 core domain from the heart of the spliceosome.",
                "URL": null,
                "raw_pages": "1199-205",
                "medline_journal": "Nat Struct Mol Biol",
                "ISO_journal": "Nat. Struct. Mol. Biol.",
                "authors": [
                    "Ritchie DB",
                    "Schellenberg MJ",
                    "Gesner EM",
                    "Raithatha SA",
                    "Stuart DT",
                    "Macmillan AM."
                ],
                "DOI_URL": "http://dx.doi.org/10.1038/nsmb.1505"
            }
        },
        "set_info": {
            "accession": "cl14782",
            "name": "RNase_H_like"
        },
        "overlaps_with": null,
        "counters": {
            "subfamilies": 0,
            "domain_architectures": 0,
            "interactions": 0,
            "matches": 4531,
            "pathways": 0,
            "proteins": 4530,
            "proteomes": 3115,
            "sets": 1,
            "structural_models": {
                "alphafold": 257,
                "bfvd": 0
            },
            "structures": 518,
            "taxa": 8785
        },
        "entry_annotations": {},
        "cross_references": {},
        "is_llm": false,
        "is_reviewed_llm": false,
        "is_updated_llm": false,
        "representative_structure": {
            "accession": "4jk8",
            "name": "Open and closed forms of R1865A human PRP8 RNase H-like domain with bound Mg ion"
        }
    }
}