HTTP 200 OK
Allow: GET, HEAD
Content-Type: application/json
InterPro-Version: 108.0
InterPro-Version-Minor: 0
Vary: Accept
{
"metadata": {
"accession": "cd12473",
"entry_id": null,
"type": "domain",
"go_terms": null,
"source_database": "cdd",
"member_databases": null,
"integrated": null,
"hierarchy": null,
"name": {
"name": "RNA recognition motif 2 (RRM2) found in vertebrate single-stranded DNA-binding protein MSSP-1",
"short": "RRM2_MSSP1"
},
"description": [
{
"text": "<p>This subgroup corresponds to the RRM2 of MSSP-1, also termed RNA-binding motif, single-stranded-interacting protein 1 (RBMS1), or suppressor of CDC2 with RNA-binding motif 2 (SCR2). MSSP-1 is a double- and single-stranded DNA binding protein that belongs to the c-myc single-strand binding proteins (MSSP) family. It specifically recognizes the sequence CT(A/T)(A/T)T, and stimulates DNA replication in the system using SV40 DNA. MSSP-1 is identical with Scr2, a human protein which complements the defect of cdc2 kinase in Schizosaccharomyces pombe. MSSP-1 has been implied in regulating DNA replication, transcription, apoptosis induction, and cell-cycle movement, via the interaction with c-MYC, the product of protooncogene c-myc. MSSP-1 contains two RNA recognition motifs (RRMs), also termed RBDs (RNA binding domains) or RNPs (ribonucleoprotein domains), both of which are responsible for the specific DNA binding activity as well as induction of apoptosis. [[cite:PUB00083486], [cite:PUB00083485], [cite:PUB00083484], [cite:PUB00083487], [cite:PUB00128529], [cite:PUB00128530], [cite:PUB00128531], [cite:PUB00083488], [cite:PUB00128532], [cite:PUB00128533], [cite:PUB00128534], [cite:PUB00079469], [cite:PUB00079470]]</p>",
"llm": false,
"checked": false,
"updated": false
}
],
"wikipedia": null,
"literature": {
"PUB00128529": {
"PMID": 10639566,
"ISBN": null,
"volume": "16",
"issue": "2",
"year": 2000,
"title": "Structures and comparison of genomic and complementary DNAs of mouse MSSP, a c-Myc binding protein.",
"URL": null,
"raw_pages": "245-51",
"medline_journal": "Int J Oncol",
"ISO_journal": "Int J Oncol",
"authors": [
"Fujimoto M",
"Matsumoto KI",
"Iguchi-Ariga SM",
"Ariga H."
],
"DOI_URL": null
},
"PUB00128532": {
"PMID": 8871567,
"ISBN": null,
"volume": "24",
"issue": "19",
"year": 1996,
"title": "Cloning and characterization of the genomic DNA of the human MSSP genes.",
"URL": null,
"raw_pages": "3846-57",
"medline_journal": "Nucleic Acids Res",
"ISO_journal": "Nucleic Acids Res",
"authors": [
"Haigermoser C",
"Fujimoto M",
"Iguchi-Ariga SM",
"Ariga H."
],
"DOI_URL": null
},
"PUB00083487": {
"PMID": 10672043,
"ISBN": null,
"volume": "5",
"issue": "2",
"year": 2000,
"title": "MSSP promotes ras/myc cooperative cell transforming activity by binding to c-Myc.",
"URL": null,
"raw_pages": "127-41",
"medline_journal": "Genes Cells",
"ISO_journal": "Genes Cells",
"authors": [
"Niki T",
"Izumi S",
"Saegusa Y",
"Taira T",
"Takai T",
"Iguchi-Ariga SM",
"Ariga H."
],
"DOI_URL": "http://dx.doi.org/10.1046/j.1365-2443.2000.00311.x"
},
"PUB00128534": {
"PMID": 11737267,
"ISBN": null,
"volume": "6",
"issue": "12",
"year": 2001,
"title": "Disruption of MSSP, c-myc single-strand binding protein, leads to embryonic lethality in some homozygous mice.",
"URL": null,
"raw_pages": "1067-75",
"medline_journal": "Genes Cells",
"ISO_journal": "Genes Cells",
"authors": [
"Fujimoto M",
"Matsumoto K",
"Iguchi-Ariga SM",
"Ariga H."
],
"DOI_URL": null
},
"PUB00079470": {
"PMID": 22278943,
"ISBN": null,
"volume": "3",
"issue": "2",
"year": 2012,
"title": "Structural insight into RNA recognition motifs: versatile molecular Lego building blocks for biological systems.",
"URL": null,
"raw_pages": "229-46",
"medline_journal": "Wiley Interdiscip Rev RNA",
"ISO_journal": "Wiley Interdiscip Rev RNA",
"authors": [
"Muto Y",
"Yokoyama S."
],
"DOI_URL": "http://dx.doi.org/10.1002/wrna.1107"
},
"PUB00079469": {
"PMID": 22516180,
"ISBN": null,
"volume": "22",
"issue": "3",
"year": 2012,
"title": "Dynamics in multi-domain protein recognition of RNA.",
"URL": null,
"raw_pages": "287-96",
"medline_journal": "Curr Opin Struct Biol",
"ISO_journal": "Curr. Opin. Struct. Biol.",
"authors": [
"Mackereth CD",
"Sattler M."
],
"DOI_URL": "http://dx.doi.org/10.1016/j.sbi.2012.03.013"
},
"PUB00128530": {
"PMID": 9729119,
"ISBN": null,
"volume": "214",
"issue": "1-2",
"year": 1998,
"title": "Characterization of an element positively regulating the transcription of MSSP gene-2 which encodes C-MYC binding proteins.",
"URL": null,
"raw_pages": "113-20",
"medline_journal": "Gene",
"ISO_journal": "Gene",
"authors": [
"Fujimoto M",
"Iguchi-Ariga SM",
"Ariga H."
],
"DOI_URL": null
},
"PUB00083488": {
"PMID": 9013798,
"ISBN": null,
"volume": "20",
"issue": "1",
"year": 1997,
"title": "Induction of apoptosis in HeLa cells by MSSP, c-myc binding proteins.",
"URL": null,
"raw_pages": "10-4",
"medline_journal": "Biol Pharm Bull",
"ISO_journal": "Biol. Pharm. Bull.",
"authors": [
"Iida M",
"Taira T",
"Ariga H",
"Iguchi-Ariga SM."
],
"DOI_URL": "http://dx.doi.org/10.1248/bpb.20.10"
},
"PUB00128533": {
"PMID": 7838710,
"ISBN": null,
"volume": "22",
"issue": "25",
"year": 1994,
"title": "Molecular cloning of MSSP-2, a c-myc gene single-strand binding protein: characterization of binding specificity and DNA replication activity.",
"URL": null,
"raw_pages": "5576-81",
"medline_journal": "Nucleic Acids Res",
"ISO_journal": "Nucleic Acids Res",
"authors": [
"Takai T",
"Nishita Y",
"Iguchi-Ariga SM",
"Ariga H."
],
"DOI_URL": null
},
"PUB00083485": {
"PMID": 8134115,
"ISBN": null,
"volume": "9",
"issue": "4",
"year": 1994,
"title": "Identification and cDNA cloning of single-stranded DNA binding proteins that interact with the region upstream of the human c-myc gene.",
"URL": null,
"raw_pages": "1133-43",
"medline_journal": "Oncogene",
"ISO_journal": "Oncogene",
"authors": [
"Negishi Y",
"Nishita Y",
"Saegusa Y",
"Kakizaki I",
"Galli I",
"Kihara F",
"Tamai K",
"Miyajima N",
"Iguchi-Ariga SM",
"Ariga H."
],
"DOI_URL": null
},
"PUB00083484": {
"PMID": 10869558,
"ISBN": null,
"volume": "475",
"issue": "3",
"year": 2000,
"title": "MSSP, a protein binding to an origin of replication in the c-myc gene, interacts with a catalytic subunit of DNA polymerase alpha and stimulates its polymerase activity.",
"URL": null,
"raw_pages": "209-12",
"medline_journal": "FEBS Lett",
"ISO_journal": "FEBS Lett.",
"authors": [
"Niki T",
"Galli I",
"Ariga H",
"Iguchi-Ariga SM."
],
"DOI_URL": "http://dx.doi.org/10.1016/S0014-5793(00)01679-3"
},
"PUB00128531": {
"PMID": 9580695,
"ISBN": null,
"volume": "26",
"issue": "10",
"year": 1998,
"title": "c-Myc gene single-strand binding protein-1, MSSP-1, suppresses transcription of alpha-smooth muscle actin gene in chicken visceral smooth muscle cells.",
"URL": null,
"raw_pages": "2420-5",
"medline_journal": "Nucleic Acids Res",
"ISO_journal": "Nucleic Acids Res",
"authors": [
"Kimura K",
"Saga H",
"Hayashi K",
"Obata H",
"Chimori Y",
"Ariga H",
"Sobue K."
],
"DOI_URL": null
},
"PUB00083486": {
"PMID": 8041632,
"ISBN": null,
"volume": "22",
"issue": "13",
"year": 1994,
"title": "SCR: novel human suppressors of cdc2/cdc13 mutants of Schizosaccharomyces pombe harbour motifs for RNA binding proteins.",
"URL": null,
"raw_pages": "2687-93",
"medline_journal": "Nucleic Acids Res",
"ISO_journal": "Nucleic Acids Res.",
"authors": [
"Kanaoka Y",
"Nojima H."
],
"DOI_URL": "http://dx.doi.org/10.1093/nar/22.13.2687"
}
},
"set_info": {
"accession": "cl17169",
"name": "RRM_SF"
},
"overlaps_with": null,
"counters": {
"subfamilies": 0,
"domain_architectures": 0,
"interactions": 0,
"matches": 1300,
"pathways": 0,
"proteins": 1300,
"proteomes": 535,
"sets": 1,
"structural_models": {
"alphafold": 1153,
"bfvd": 0
},
"structures": 3,
"taxa": 1673
},
"entry_annotations": {},
"cross_references": {},
"is_llm": false,
"is_reviewed_llm": false,
"is_updated_llm": false,
"representative_structure": null
}
}
