General Handler

HTTP 200 OK
Allow: GET, HEAD
Content-Type: application/json
InterPro-Version: 108.0
InterPro-Version-Minor: 0
Vary: Accept

{
    "metadata": {
        "accession": "cd09757",
        "entry_id": null,
        "type": "domain",
        "go_terms": null,
        "source_database": "cdd",
        "member_databases": null,
        "integrated": null,
        "hierarchy": null,
        "name": {
            "name": "CRISPR/Cas system-associated protein Cas8c",
            "short": "Cas8c_I-C"
        },
        "description": [
            {
                "text": "<p>CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) and associated Cas proteins comprise a system for heritable host defense by prokaryotic cells against phage and other foreign DNA; Zn-finger domain containing protein, distant homologs of Cas8 proteins; signature gene for I-C subtype; also known as Csd1 family [[cite:PUB00043288], [cite:PUB00020781]]</p>",
                "llm": false,
                "checked": false,
                "updated": false
            }
        ],
        "wikipedia": null,
        "literature": {
            "PUB00043288": {
                "PMID": 16545108,
                "ISBN": null,
                "volume": "1",
                "issue": null,
                "year": 2006,
                "title": "A putative RNA-interference-based immune system in prokaryotes: computational analysis of the predicted enzymatic machinery, functional analogies with eukaryotic RNAi, and hypothetical mechanisms of action.",
                "URL": null,
                "raw_pages": "7",
                "medline_journal": "Biol Direct",
                "ISO_journal": "Biol. Direct",
                "authors": [
                    "Makarova KS",
                    "Grishin NV",
                    "Shabalina SA",
                    "Wolf YI",
                    "Koonin EV."
                ],
                "DOI_URL": "http://dx.doi.org/10.1186/1745-6150-1-7"
            },
            "PUB00020781": {
                "PMID": 16292354,
                "ISBN": null,
                "volume": "1",
                "issue": "6",
                "year": 2005,
                "title": "A guild of 45 CRISPR-associated (Cas) protein families and multiple CRISPR/Cas subtypes exist in prokaryotic genomes.",
                "URL": null,
                "raw_pages": "e60",
                "medline_journal": "PLoS Comput Biol",
                "ISO_journal": "PLoS Comput. Biol.",
                "authors": [
                    "Haft DH",
                    "Selengut J",
                    "Mongodin EF",
                    "Nelson KE."
                ],
                "DOI_URL": "http://dx.doi.org/10.1371/journal.pcbi.0010060"
            }
        },
        "set_info": {
            "accession": "cl12004",
            "name": "Cas8c_I-C"
        },
        "overlaps_with": null,
        "counters": {
            "subfamilies": 0,
            "domain_architectures": 0,
            "interactions": 0,
            "matches": 1396,
            "pathways": 0,
            "proteins": 1396,
            "proteomes": 981,
            "sets": 1,
            "structural_models": {
                "alphafold": 1092,
                "bfvd": 0
            },
            "structures": 11,
            "taxa": 2415
        },
        "entry_annotations": {},
        "cross_references": {},
        "is_llm": false,
        "is_reviewed_llm": false,
        "is_updated_llm": false,
        "representative_structure": null
    }
}