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{
"metadata": {
"accession": "cd08632",
"entry_id": null,
"type": "domain",
"go_terms": null,
"source_database": "cdd",
"member_databases": null,
"integrated": "IPR028392",
"hierarchy": null,
"name": {
"name": "Catalytic domain of metazoan phosphoinositide-specific phospholipase C-eta1",
"short": "PI-PLCc_eta1"
},
"description": [
{
"text": "<p>This subfamily corresponds to the catalytic domain present in metazoan phosphoinositide-specific phospholipase C (PI-PLC, EC 3.1.4.11)-eta isozyme 1. PI-PLC is a signaling enzyme that hydrolyzes the membrane phospholipids phosphatidylinositol-4,5-bisphosphate (PIP2) to generate two important second messengers in eukaryotic signal transduction cascades, Inositol 1,4,5-trisphosphate (InsP3) and diacylglycerol (DAG). InsP3 triggers inflow of calcium from intracellular stores, while DAG, together with calcium, activates protein kinase C, which then phosphorylates other molecules, leading to altered cellular activity. Calcium is required for the catalysis. PI-PLC-eta represents a class of neuron-speific PI-PLC that has an N-terminal pleckstrin homology (PH) domain, an array of EF hands, a PLC catalytic core domain, a C2 domain, and a unique C-terminal tail that terminates with a PDZ-binding motif, a potential interaction site for other signaling proteins. The PLC catalytic core domain is a TIM barrel with two highly conserved regions (X and Y) split by a highly degenerate linker sequence. PI-PLC-eta1 is a neuron-specific enzyme and expressed in only nerve tissues such as the brain and spinal cord. It may perform a fundamental role in the brain. [[cite:PUB00068283], [cite:PUB00123259], [cite:PUB00101533], [cite:PUB00112991], [cite:PUB00068280]]</p>",
"llm": false,
"checked": false,
"updated": false
}
],
"wikipedia": null,
"literature": {
"PUB00068280": {
"PMID": 15702972,
"ISBN": null,
"volume": "389",
"issue": "Pt 1",
"year": 2005,
"title": "Molecular cloning and characterization of a novel phospholipase C, PLC-eta.",
"URL": null,
"raw_pages": "181-6",
"medline_journal": "Biochem J",
"ISO_journal": "Biochem. J.",
"authors": [
"Hwang JI",
"Oh YS",
"Shin KJ",
"Kim H",
"Ryu SH",
"Suh PG."
],
"DOI_URL": "http://dx.doi.org/10.1042/BJ20041677"
},
"PUB00123259": {
"PMID": 16238548,
"ISBN": null,
"volume": "391",
"issue": "Pt 3",
"year": 2005,
"title": "New insights into the families of PLC enzymes: looking back and going forward.",
"URL": null,
"raw_pages": "e7-9",
"medline_journal": "Biochem J",
"ISO_journal": "Biochem J",
"authors": [
"Katan M."
],
"DOI_URL": null
},
"PUB00068283": {
"PMID": 15899900,
"ISBN": null,
"volume": "280",
"issue": "32",
"year": 2005,
"title": "A novel phospholipase C, PLC(eta)2, is a neuron-specific isozyme.",
"URL": null,
"raw_pages": "29128-34",
"medline_journal": "J Biol Chem",
"ISO_journal": "J. Biol. Chem.",
"authors": [
"Nakahara M",
"Shimozawa M",
"Nakamura Y",
"Irino Y",
"Morita M",
"Kudo Y",
"Fukami K."
],
"DOI_URL": "http://dx.doi.org/10.1074/jbc.M503817200"
},
"PUB00112991": {
"PMID": 17895620,
"ISBN": null,
"volume": "86",
"issue": "4",
"year": 2007,
"title": "Phospholipase C-eta enzymes as putative protein kinase C and Ca2+ signalling components in neuronal and neuroendocrine tissues.",
"URL": null,
"raw_pages": "243-8",
"medline_journal": "Neuroendocrinology",
"ISO_journal": "Neuroendocrinology",
"authors": [
"Stewart AJ",
"Morgan K",
"Farquharson C",
"Millar RP."
],
"DOI_URL": null
},
"PUB00101533": {
"PMID": 16310357,
"ISBN": null,
"volume": "31",
"issue": "1",
"year": 2006,
"title": "The latest phospholipase C, PLCeta, is implicated in neuronal function.",
"URL": null,
"raw_pages": "4-7",
"medline_journal": "Trends Biochem Sci",
"ISO_journal": "Trends Biochem Sci",
"authors": [
"Cockcroft S."
],
"DOI_URL": null
}
},
"set_info": {
"accession": "cl14615",
"name": "PI-PLCc_GDPD_SF"
},
"overlaps_with": null,
"counters": {
"subfamilies": 0,
"domain_architectures": 0,
"interactions": 0,
"matches": 702,
"pathways": 0,
"proteins": 702,
"proteomes": 271,
"sets": 1,
"structural_models": {
"alphafold": 154,
"bfvd": 0
},
"structures": 0,
"taxa": 860
},
"entry_annotations": {},
"cross_references": {},
"is_llm": false,
"is_reviewed_llm": false,
"is_updated_llm": false,
"representative_structure": null
}
}
