"accession"	"counters"	"cross_references"	"description"	"entry_id"	"go_terms"	"hierarchy"	"integrated"	"is_llm"	"is_reviewed_llm"	"is_updated_llm"	"literature"	"member_databases"	"name"	"overlaps_with"	"representative_structure"	"set_info"	"source_database"	"type"	"wikipedia"
"cd08376"	"{'subfamilies': 0, 'domain_architectures': 0, 'interactions': 0, 'matches': 4154, 'pathways': 0, 'proteins': 4154, 'proteomes': 925, 'sets': 1, 'structural_models': {'alphafold': 3709, 'bfvd': 0}, 'structures': 0, 'taxa': 3359}"	"{}"	"[{'text': '<p>MCTPs are involved in Ca2+ signaling at the membrane.  MCTP is composed of a variable N-terminal sequence, three C2 domains, two transmembrane regions (TMRs), and a short C-terminal sequence.  It is one of four protein classes that are anchored to membranes via a transmembrane region; the others being synaptotagmins, extended synaptotagmins, and ferlins. MCTPs are the only membrane-bound C2 domain proteins that contain two functional TMRs. MCTPs are unique in that they bind Ca2+ but not phospholipids. C2 domains fold into an 8-standed beta-sandwich that can adopt 2 structural arrangements: Type I and Type II, distinguished by a circular permutation involving their N- and C-terminal beta strands. Many C2 domains are Ca2+-dependent membrane-targeting modules that bind a wide variety of substances including bind phospholipids, inositol polyphosphates, and intracellular proteins.  Most C2 domain proteins are either signal transduction enzymes that contain a single C2 domain, such as protein kinase C, or membrane trafficking proteins which contain at least two C2 domains, such as synaptotagmin 1.  However, there are a few exceptions to this including RIM isoforms and some splice variants of piccolo/aczonin and intersectin which only have a single C2 domain.  C2 domains with a calcium binding region have negatively charged residues, primarily aspartates, that serve as ligands for calcium ions. This cd contains the second C2 repeat, C2B, and has a type-II topology. [[cite:PUB00081546], [cite:PUB00081547], [cite:PUB00005039], [cite:PUB00081548], [cite:PUB00035009], [cite:PUB00000918], [cite:PUB00035040], [cite:PUB00035039]]</p>', 'llm': False, 'checked': False, 'updated': False}]"	""	""	""	""	False	False	False	"{'PUB00035009': {'PMID': 7791877, 'ISBN': None, 'volume': '375', 'issue': '6532', 'year': 1995, 'title': 'Ca(2+)-dependent and -independent activities of neural and non-neural synaptotagmins.', 'URL': None, 'raw_pages': '594-9', 'medline_journal': 'Nature', 'ISO_journal': 'Nature', 'authors': ['Li C', 'Ullrich B', 'Zhang JZ', 'Anderson RG', 'Brose N', 'Sudhof TC.'], 'DOI_URL': 'http://dx.doi.org/10.1038/375594a0'}, 'PUB00035040': {'PMID': 1589771, 'ISBN': None, 'volume': '256', 'issue': '5059', 'year': 1992, 'title': 'Synaptotagmin: a calcium sensor on the synaptic vesicle surface.', 'URL': None, 'raw_pages': '1021-5', 'medline_journal': 'Science', 'ISO_journal': 'Science', 'authors': ['Brose N', 'Petrenko AG', 'Sudhof TC', 'Jahn R.'], 'DOI_URL': 'http://www.sciencemag.org/cgi/content/abstract/256/5059/1021'}, 'PUB00081548': {'PMID': 8662510, 'ISBN': None, 'volume': '273', 'issue': '5272', 'year': 1996, 'title': 'Bipartite Ca2+-binding motif in C2 domains of synaptotagmin and protein kinase C.', 'URL': None, 'raw_pages': '248-51', 'medline_journal': 'Science', 'ISO_journal': 'Science', 'authors': ['Shao X', 'Davletov BA', 'Sutton RB', 'Sudhof TC', 'Rizo J.'], 'DOI_URL': 'http://dx.doi.org/10.1126/science.273.5272.248'}, 'PUB00000918': {'PMID': 7697723, 'ISBN': None, 'volume': '80', 'issue': '6', 'year': 1995, 'title': 'Structure of the first C2 domain of synaptotagmin I: a novel Ca2+/phospholipid-binding fold.', 'URL': None, 'raw_pages': '929-38', 'medline_journal': 'Cell', 'ISO_journal': 'Cell', 'authors': ['Sutton RB', 'Davletov BA', 'Berghuis AM', 'Sudhof TC', 'Sprang SR.'], 'DOI_URL': 'http://dx.doi.org/10.1016/0092-8674(95)90296-1'}, 'PUB00005039': {'PMID': 8771209, 'ISBN': None, 'volume': '5', 'issue': '1', 'year': 1996, 'title': 'Extending the C2 domain family: C2s in PKCs delta, epsilon, eta, theta, phospholipases, GAPs, and perforin.', 'URL': None, 'raw_pages': '162-6', 'medline_journal': 'Protein Sci', 'ISO_journal': 'Protein Sci.', 'authors': ['Ponting CP', 'Parker PJ.'], 'DOI_URL': 'http://ukpmc.ac.uk/picrender.cgi?tool=EBI&pubmedid=8771209&action=stream&blobtype=pdf'}, 'PUB00081547': {'PMID': 8976547, 'ISBN': None, 'volume': '5', 'issue': '12', 'year': 1996, 'title': 'The C2 domain calcium-binding motif: structural and functional diversity.', 'URL': None, 'raw_pages': '2375-90', 'medline_journal': 'Protein Sci', 'ISO_journal': 'Protein Sci.', 'authors': ['Nalefski EA', 'Falke JJ.'], 'DOI_URL': 'http://dx.doi.org/10.1002/pro.5560051201'}, 'PUB00081546': {'PMID': 9632630, 'ISBN': None, 'volume': '273', 'issue': '26', 'year': 1998, 'title': 'C2-domains, structure and function of a universal Ca2+-binding domain.', 'URL': None, 'raw_pages': '15879-82', 'medline_journal': 'J Biol Chem', 'ISO_journal': 'J. Biol. Chem.', 'authors': ['Rizo J', 'Sudhof TC.'], 'DOI_URL': 'http://dx.doi.org/10.1074/jbc.273.26.15879'}, 'PUB00035039': {'PMID': 2333096, 'ISBN': None, 'volume': '345', 'issue': '6272', 'year': 1990, 'title': 'Phospholipid binding by a synaptic vesicle protein homologous to the regulatory region of protein kinase C.', 'URL': None, 'raw_pages': '260-3', 'medline_journal': 'Nature', 'ISO_journal': 'Nature', 'authors': ['Perin MS', 'Fried VA', 'Mignery GA', 'Jahn R', 'Sudhof TC.'], 'DOI_URL': 'http://dx.doi.org/10.1038/345260a0'}}"	""	"{'name': 'C2 domain second repeat found in Multiple C2 domain and Transmembrane region Proteins (MCTP)', 'short': 'C2B_MCTP_PRT'}"	""	""	"{'accession': 'cl14603', 'name': 'C2'}"	"cdd"	"domain"	""