"accession"	"counters"	"cross_references"	"description"	"entry_id"	"go_terms"	"hierarchy"	"integrated"	"is_llm"	"is_reviewed_llm"	"is_updated_llm"	"literature"	"member_databases"	"name"	"overlaps_with"	"representative_structure"	"set_info"	"source_database"	"type"	"wikipedia"
"cd03693"	"{'subfamilies': 0, 'domain_architectures': 0, 'interactions': 0, 'matches': 57086, 'pathways': 0, 'proteins': 57042, 'proteomes': 3906, 'sets': 1, 'structural_models': {'alphafold': 48932, 'bfvd': 0}, 'structures': 34, 'taxa': 56727}"	"{}"	"[{'text': ""<p>This family represents domain II of elongation factor 1-alpha (EF-1A) that is found in archaea and all eukaryotic lineages. EF-1A is very abundant in the cytosol, where it is involved in the GTP-dependent binding of aminoacyl-tRNAs to the A site of the ribosomes in the second step of translation from mRNAs to proteins. Both domain II of EF-1A and domain IV of IF2/eIF5B have been implicated in recognition of the 3'-ends of tRNA. More than 61% of eukaryotic elongation factor 1A (eEF-1A) in cells is estimated to be associated with actin cytoskeleton. The binding of eEF-1A to actin is a noncanonical function that may link two distinct cellular processes, cytoskeleton organization and gene expression. [[cite:PUB00115982], [cite:PUB00115983], [cite:PUB00115094], [cite:PUB00080181], [cite:PUB00033952], [cite:PUB00027704], [cite:PUB00033961], [cite:PUB00079814], [cite:PUB00007398]]</p>"", 'llm': False, 'checked': False, 'updated': False}]"	""	""	""	""	False	False	False	"{'PUB00033961': {'PMID': 12102560, 'ISBN': None, 'volume': '71', 'issue': None, 'year': 2002, 'title': 'Mechanisms of EF-Tu, a pioneer GTPase.', 'URL': None, 'raw_pages': '513-51', 'medline_journal': 'Prog Nucleic Acid Res Mol Biol', 'ISO_journal': 'Prog. Nucleic Acid Res. Mol. Biol.', 'authors': ['Krab IM', 'Parmeggiani A.'], 'DOI_URL': 'http://dx.doi.org/10.1016/S0079-6603(02)71050-7'}, 'PUB00115094': {'PMID': 10950927, 'ISBN': None, 'volume': '68', 'issue': '1', 'year': 2000, 'title': 'The human elongation factor 1 A-2 gene (EEF1A2): complete sequence and characterization of gene structure and promoter activity.', 'URL': None, 'raw_pages': '63-70', 'medline_journal': 'Genomics', 'ISO_journal': 'Genomics', 'authors': ['Bischoff C', 'Kahns S', 'Lund A', 'Jorgensen HF', 'Praestegaard M', 'Clark BF', 'Leffers H.'], 'DOI_URL': None}, 'PUB00027704': {'PMID': 16213500, 'ISBN': None, 'volume': '579', 'issue': '25', 'year': 2005, 'title': 'How can elongation factors EF-G and EF-Tu discriminate the functional state of the ribosome using the same binding site?', 'URL': None, 'raw_pages': '5439-42', 'medline_journal': 'FEBS Lett', 'ISO_journal': 'FEBS Lett.', 'authors': ['Sergiev PV', 'Bogdanov AA', 'Dontsova OA.'], 'DOI_URL': 'http://dx.doi.org/10.1016/j.febslet.2005.09.010'}, 'PUB00007398': {'PMID': 7491491, 'ISBN': None, 'volume': '270', 'issue': '5241', 'year': 1995, 'title': 'Crystal structure of the ternary complex of Phe-tRNAPhe, EF-Tu, and a GTP analog.', 'URL': None, 'raw_pages': '1464-72', 'medline_journal': 'Science', 'ISO_journal': 'Science', 'authors': ['Nissen P', 'Kjeldgaard M', 'Thirup S', 'Polekhina G', 'Reshetnikova L', 'Clark BF', 'Nyborg J.'], 'DOI_URL': 'http://www.sciencemag.org/cgi/content/abstract/270/5241/1464'}, 'PUB00115982': {'PMID': 16652225, 'ISBN': None, 'volume': '286', 'issue': '1-2', 'year': 2006, 'title': 'Identification of elongation factor 1alpha as a potential associated binding partner for Akt2.', 'URL': None, 'raw_pages': '17-22', 'medline_journal': 'Mol Cell Biochem', 'ISO_journal': 'Mol Cell Biochem', 'authors': ['Lau J', 'Castelli LA', 'Lin EC', 'Macaulay SL.'], 'DOI_URL': None}, 'PUB00115983': {'PMID': 11854414, 'ISBN': None, 'volume': '13', 'issue': '2', 'year': 2002, 'title': 'Interactions of elongation factor 1alpha with F-actin and beta-actin mRNA: implications for anchoring mRNA in cell protrusions.', 'URL': None, 'raw_pages': '579-92', 'medline_journal': 'Mol Biol Cell', 'ISO_journal': 'Mol Biol Cell', 'authors': ['Liu G', 'Grant WM', 'Persky D', 'Latham VM Jr', 'Singer RH', 'Condeelis J.'], 'DOI_URL': None}, 'PUB00033952': {'PMID': 15922593, 'ISBN': None, 'volume': '15', 'issue': '3', 'year': 2005, 'title': 'Elongation factors on the ribosome.', 'URL': None, 'raw_pages': '349-54', 'medline_journal': 'Curr Opin Struct Biol', 'ISO_journal': 'Curr. Opin. Struct. Biol.', 'authors': ['Nilsson J', 'Nissen P.'], 'DOI_URL': 'http://dx.doi.org/10.1016/j.sbi.2005.05.004'}, 'PUB00079814': {'PMID': 11909526, 'ISBN': None, 'volume': '108', 'issue': '4', 'year': 2002, 'title': 'Ribosome structure and the mechanism of translation.', 'URL': None, 'raw_pages': '557-72', 'medline_journal': 'Cell', 'ISO_journal': 'Cell', 'authors': ['Ramakrishnan V.'], 'DOI_URL': 'http://dx.doi.org/10.1016/S0092-8674(02)00619-0'}, 'PUB00080181': {'PMID': 15952884, 'ISBN': None, 'volume': '74', 'issue': None, 'year': 2005, 'title': 'Structural insights into translational fidelity.', 'URL': None, 'raw_pages': '129-77', 'medline_journal': 'Annu Rev Biochem', 'ISO_journal': 'Annu. Rev. Biochem.', 'authors': ['Ogle JM', 'Ramakrishnan V.'], 'DOI_URL': 'http://dx.doi.org/10.1146/annurev.biochem.74.061903.155440'}}"	""	"{'name': 'Domain II of elongation factor 1-alpha', 'short': 'EF1_alpha_II'}"	""	""	"{'accession': 'cl02787', 'name': 'Translation_Factor_II_like'}"	"cdd"	"domain"	""