General Handler

HTTP 200 OK
Allow: GET, HEAD
Content-Type: application/json
InterPro-Version: 108.0
InterPro-Version-Minor: 0
Vary: Accept

{
    "metadata": {
        "accession": "IPR052532",
        "entry_id": null,
        "type": "family",
        "go_terms": null,
        "source_database": "interpro",
        "member_databases": {
            "panther": {
                "PTHR42828": "SUA5 domain-containing protein"
            }
        },
        "integrated": null,
        "hierarchy": {
            "accession": "IPR052532",
            "name": "Threonylcarbamoyl-AMP synthase YciO",
            "type": "Family",
            "children": []
        },
        "name": {
            "name": "Threonylcarbamoyl-AMP synthase YciO",
            "short": "YciO"
        },
        "description": [
            {
                "text": "<p>This entry represents Threonylcarbamoyl-AMP synthase YciO and related proteins. It catalyes the conversion of L-threonine, HCO3-/CO2 and ATP to give threonylcarbamoyl-AMP (TC-AMP) as the acyladenylate intermediate, with the release of diphosphate [[cite:PUB00163278]]. YciO shows ATP hydrolysis activity in vitro, producing AMP [[cite:PUB00163278]].</p>",
                "llm": true,
                "checked": true,
                "updated": true
            }
        ],
        "wikipedia": null,
        "literature": {
            "PUB00163278": {
                "PMID": 37963869,
                "ISBN": null,
                "volume": "14",
                "issue": "1",
                "year": 2023,
                "title": "Functional annotation of enzyme-encoding genes using deep learning with transformer layers.",
                "URL": null,
                "raw_pages": "7370",
                "medline_journal": "Nat Commun",
                "ISO_journal": "Nat Commun",
                "authors": [
                    "Kim GB",
                    "Kim JY",
                    "Lee JA",
                    "Norsigian CJ",
                    "Palsson BO",
                    "Lee SY."
                ],
                "DOI_URL": "https://doi.org/10.1038/s41467-023-43216-z"
            }
        },
        "set_info": null,
        "overlaps_with": [
            {
                "accession": "IPR017945",
                "name": "DHBP synthase RibB-like alpha/beta domain superfamily",
                "type": "homologous_superfamily"
            }
        ],
        "counters": {
            "subfamilies": 0,
            "domain_architectures": 0,
            "interactions": 0,
            "matches": 11728,
            "pathways": 0,
            "proteins": 11728,
            "proteomes": 8478,
            "sets": 0,
            "structural_models": {
                "alphafold": 8708,
                "bfvd": 0
            },
            "structures": 2,
            "taxa": 13832
        },
        "entry_annotations": {},
        "cross_references": {
            "ec": {
                "displayName": "ENZYME",
                "description": "ENZYME is a repository of information relative to the nomenclature of enzymes. It is primarily based on the recommendations of the Nomenclature Committee of the International Union of Biochemistry and Molecular Biology (IUBMB) and it describes each type of characterized enzyme for which an EC (Enzyme Commission) number has been provided.",
                "rank": 19,
                "accessions": [
                    {
                        "accession": "2.7.7.87",
                        "url": "https://enzyme.expasy.org/EC/2.7.7.87"
                    }
                ]
            }
        },
        "is_llm": true,
        "is_reviewed_llm": true,
        "is_updated_llm": true,
        "representative_structure": {
            "accession": "1k7j",
            "name": "Structural Genomics, protein TF1"
        }
    }
}