{"metadata":{"accession":"IPR051765","entry_id":null,"type":"family","go_terms":null,"source_database":"interpro","member_databases":{"panther":{"PTHR46280":"Pleckstrin homology domain-containing family F"}},"integrated":null,"hierarchy":{"accession":"IPR051765","name":"Pleckstrin homology domain-containing family F","type":"Family","children":[]},"name":{"name":"Pleckstrin homology domain-containing family F","short":"PH_domain-containing_F"},"description":[{"text":"<p>The Pleckstrin homology domain-containing family F is involved in various cellular processes including endosome fusion, receptor trafficking, fluid-phase transport, and apoptosis. Members of the family may enhance cellular sensitivity to TNF-induced apoptosis and play a role upstream of RAB5. The family's PH and FYVE domains are critical for localization to endosomes and the endoplasmic reticulum, and for initiating apoptosis through the lysosomal-mitochondrial pathway. This includes translocation to lysosomes, permeabilization of the lysosomal membrane, release of lysosomal enzymes, and alteration of mitochondrial membrane permeability, leading to caspase-independent cell death.</p>","llm":true,"checked":false,"updated":false}],"wikipedia":null,"literature":null,"set_info":null,"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":0,"interactions":0,"matches":2912,"pathways":0,"proteins":2912,"proteomes":1338,"sets":0,"structural_models":{"alphafold":2682,"bfvd":0},"structures":0,"taxa":4691},"entry_annotations":{},"cross_references":{},"is_llm":true,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}