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{
    "metadata": {
        "accession": "IPR051765",
        "entry_id": null,
        "type": "family",
        "go_terms": null,
        "source_database": "interpro",
        "member_databases": {
            "panther": {
                "PTHR46280": "Pleckstrin homology domain-containing family F"
            }
        },
        "integrated": null,
        "hierarchy": {
            "accession": "IPR051765",
            "name": "Pleckstrin homology domain-containing family F",
            "type": "Family",
            "children": []
        },
        "name": {
            "name": "Pleckstrin homology domain-containing family F",
            "short": "PH_domain-containing_F"
        },
        "description": [
            {
                "text": "<p>The Pleckstrin homology domain-containing family F is involved in various cellular processes including endosome fusion, receptor trafficking, fluid-phase transport, and apoptosis. Members of the family may enhance cellular sensitivity to TNF-induced apoptosis and play a role upstream of RAB5. The family's PH and FYVE domains are critical for localization to endosomes and the endoplasmic reticulum, and for initiating apoptosis through the lysosomal-mitochondrial pathway. This includes translocation to lysosomes, permeabilization of the lysosomal membrane, release of lysosomal enzymes, and alteration of mitochondrial membrane permeability, leading to caspase-independent cell death.</p>",
                "llm": true,
                "checked": false,
                "updated": false
            }
        ],
        "wikipedia": null,
        "literature": null,
        "set_info": null,
        "overlaps_with": null,
        "counters": {
            "subfamilies": 0,
            "domain_architectures": 0,
            "interactions": 0,
            "matches": 2912,
            "pathways": 0,
            "proteins": 2912,
            "proteomes": 1338,
            "sets": 0,
            "structural_models": {
                "alphafold": 2682,
                "bfvd": 0
            },
            "structures": 0,
            "taxa": 4691
        },
        "entry_annotations": {},
        "cross_references": {},
        "is_llm": true,
        "is_reviewed_llm": false,
        "is_updated_llm": false,
        "representative_structure": null
    }
}