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{
    "metadata": {
        "accession": "IPR050313",
        "entry_id": null,
        "type": "family",
        "go_terms": null,
        "source_database": "interpro",
        "member_databases": {
            "panther": {
                "PTHR30363": "Carbohydrate Metabolism HTH-type Transcriptional Regulators"
            }
        },
        "integrated": null,
        "hierarchy": {
            "accession": "IPR050313",
            "name": "Carbohydrate Metabolism HTH-type Transcriptional Regulators",
            "type": "Family",
            "children": []
        },
        "name": {
            "name": "Carbohydrate Metabolism HTH-type Transcriptional Regulators",
            "short": "Carb_Metab_HTH_regulators"
        },
        "description": [
            {
                "text": "<p>The protein family is comprised of helix-turn-helix (HTH) type transcriptional regulators that are involved in the repression or activation of various operons related to carbohydrate transport and metabolism. Members of this family function as repressors for operons such as aga, ula, gat, and glycerol-3-phosphate regulon, or as activators like the fuc operon. They respond to specific inducers, which can lead to the de-repression of the target genes. The regulators bind to DNA and modulate the transcription of genes involved in the utilization of sugars like N-acetyl galactosamine, lactose, L-fucose, and galactitol. Some members are also involved in carbon catabolite repression and the regulation of genes encoding metabolic enzymes. The activity of these regulators is crucial for the efficient utilization of carbohydrates and for the adaptive response of bacteria to different environmental nutrient sources.</p>",
                "llm": true,
                "checked": false,
                "updated": false
            }
        ],
        "wikipedia": null,
        "literature": null,
        "set_info": null,
        "overlaps_with": [
            {
                "accession": "IPR037171",
                "name": "NagB/RpiA transferase-like",
                "type": "homologous_superfamily"
            }
        ],
        "counters": {
            "subfamilies": 0,
            "domain_architectures": 0,
            "interactions": 0,
            "matches": 71906,
            "pathways": 0,
            "proteins": 71906,
            "proteomes": 12850,
            "sets": 0,
            "structural_models": {
                "alphafold": 53755,
                "bfvd": 0
            },
            "structures": 1,
            "taxa": 19955
        },
        "entry_annotations": {},
        "cross_references": {},
        "is_llm": true,
        "is_reviewed_llm": false,
        "is_updated_llm": false,
        "representative_structure": {
            "accession": "7l6l",
            "name": "Crystal Structure of the DNA-binding Transcriptional Repressor DeoR from Escherichia coli str. K-12"
        }
    }
}