{"metadata":{"accession":"IPR045896","entry_id":null,"type":"domain","go_terms":null,"source_database":"interpro","member_databases":{"cdd":{"cd18918":"basic Helix-Loop-Helix (bHLH) domain found in Arabidopsis thaliana MYC1 and similar proteins"}},"integrated":null,"hierarchy":{"accession":"IPR011598","name":"Myc-type, basic helix-loop-helix (bHLH) domain","type":"Domain","children":[{"accession":"IPR015789","name":"Twist-related, basic helix-loop-helix domain","type":"Domain","children":[]},{"accession":"IPR024098","name":"Transcription factor EB, bHLHzip domain","type":"Domain","children":[]},{"accession":"IPR024100","name":"Transcription factor E3, bHLHzip domain","type":"Domain","children":[]},{"accession":"IPR032644","name":"Transcription factor HES-7, basic helix-loop-helix-orange domain","type":"Domain","children":[]},{"accession":"IPR032655","name":"Neurogenin-2, basic helix-loop-helix domain","type":"Domain","children":[]},{"accession":"IPR032656","name":"Neurogenin-3, basic helix-loop-helix domain","type":"Domain","children":[]},{"accession":"IPR032657","name":"Oligodendrocyte transcription factor 1, basic helix-loop-helix domain","type":"Domain","children":[]},{"accession":"IPR032658","name":"Oligodendrocyte transcription factor 2, basic helix-loop-helix domain","type":"Domain","children":[]},{"accession":"IPR032659","name":"Oligodendrocyte transcription factor 3, basic helix-loop-helix domain","type":"Domain","children":[]},{"accession":"IPR032660","name":"Transcription factor ATOH8, basic helix-loop-helix domain","type":"Domain","children":[]},{"accession":"IPR032661","name":"Transcription factor ATOH1, basic helix-loop-helix domain","type":"Domain","children":[]},{"accession":"IPR033348","name":"Aryl hydrocarbon receptor, basic helix-loop-helix domain","type":"Domain","children":[]},{"accession":"IPR039092","name":"Aryl hydrocarbon receptor repressor, basic helix-loop-helix domain","type":"Domain","children":[]},{"accession":"IPR040106","name":"Protein Esc1, basic helix-loop-helix-zipper domain","type":"Domain","children":[]},{"accession":"IPR045239","name":"Transcription factor bHLH95-like, basic helix-loop-helix domain","type":"Domain","children":[]},{"accession":"IPR045896","name":"Transcription factor MYC1-like, bHLH domain","type":"Domain","children":[]},{"accession":"IPR047093","name":"Twist-related protein 1, basic helix-loop-helix domain","type":"Domain","children":[]},{"accession":"IPR047094","name":"Twist-related protein 2, basic helix-loop-helix domain","type":"Domain","children":[]},{"accession":"IPR047206","name":"Centromere-binding protein 1-like, bHLHzip domain","type":"Domain","children":[]},{"accession":"IPR047265","name":"Transcription factor PIF1-like, basic helix-loop-helix domain","type":"Domain","children":[]},{"accession":"IPR048064","name":"Upstream transcription factor 3, basic helix-loop-helix domain","type":"Domain","children":[]},{"accession":"IPR056192","name":"NPAS4, bHLH domain","type":"Domain","children":[]},{"accession":"IPR056193","name":"Nuclear receptor coactivator 1-3, bHLH domain","type":"Domain","children":[{"accession":"IPR028819","name":"Nuclear receptor coactivator 1, basic helix-loop-helix","type":"Domain","children":[]},{"accession":"IPR028822","name":"Nuclear receptor coactivator 2, basic helix-loop-helix","type":"Domain","children":[]},{"accession":"IPR056194","name":"Nuclear receptor coactivator 3, basic helix-loop-helix","type":"Domain","children":[]}]},{"accession":"IPR057071","name":"INO2 bHLH domain","type":"Domain","children":[]},{"accession":"IPR057072","name":"INO4, bHLH domain","type":"Domain","children":[]},{"accession":"IPR057075","name":"Iron-related transcription factor 3, bHLH domain","type":"Domain","children":[]}]},"name":{"name":"Transcription factor MYC1-like, bHLH domain","short":"MYC1-like_bHLH"},"description":[{"text":"<p>This entry represents the basic helix-loop-helix (bHLH) domain found in a group of plant transcription factors. This entry includes MYC1 and bHLH91 from Arabidopsis thaliana and EAT1 from Oryza sativa.</p>\n\n<p>MYC1 (also known as BHLH12) is an important regulator of trichome and root hair initiation [[cite:PUB00099223]].</p>\n\n<p>bHLH91 is involved in pollen development. This protein is important for the normal transcriptome of the developing Arabidopsis anther, possibly by forming a feed-forward loop with DYT1 [[cite:PUB00099219], [cite:PUB00099220]].</p>\n\n<p>EAT1 participates in the regulation of tapetum programmed cell death (PCD) and degradation during male reproductive development in rice [[cite:PUB00099221], [cite:PUB00099222]].</p>","llm":false,"checked":false,"updated":false}],"wikipedia":null,"literature":{"PUB00099219":{"PMID":33393464,"ISBN":null,"volume":"47","issue":"8","year":2020,"title":"Analyses of functional conservation and divergence reveal requirement of bHLH010/089/091 for pollen development at elevated temperature in Arabidopsis.","URL":null,"raw_pages":"477-492","medline_journal":"J Genet Genomics","ISO_journal":"J Genet Genomics","authors":["Fu Y","Li M","Zhang S","Yang Q","Zhu E","You C","Qi J","Ma H","Chang F."],"DOI_URL":null},"PUB00099220":{"PMID":26216374,"ISBN":null,"volume":"83","issue":"6","year":2015,"title":"The DYT1-interacting proteins bHLH010, bHLH089 and bHLH091 are redundantly required for Arabidopsis anther development and transcriptome.","URL":null,"raw_pages":"976-90","medline_journal":"Plant J","ISO_journal":"Plant J","authors":["Zhu E","You C","Wang S","Cui J","Niu B","Wang Y","Qi J","Ma H","Chang F."],"DOI_URL":null},"PUB00099221":{"PMID":23519457,"ISBN":null,"volume":"6","issue":"5","year":2013,"title":"A novel rice bHLH transcription factor, DTD, acts coordinately with TDR in controlling tapetum function and pollen development.","URL":null,"raw_pages":"1715-8","medline_journal":"Mol Plant","ISO_journal":"Mol Plant","authors":["Ji C","Li H","Chen L","Xie M","Wang F","Chen Y","Liu YG."],"DOI_URL":null},"PUB00099222":{"PMID":23385589,"ISBN":null,"volume":"4","issue":null,"year":2013,"title":"EAT1 promotes tapetal cell death by regulating aspartic proteases during male reproductive development in rice.","URL":null,"raw_pages":"1445","medline_journal":"Nat Commun","ISO_journal":"Nat Commun","authors":["Niu N","Liang W","Yang X","Jin W","Wilson ZA","Hu J","Zhang D."],"DOI_URL":null},"PUB00099223":{"PMID":22334670,"ISBN":null,"volume":"287","issue":"17","year":2012,"title":"A single amino acid substitution in IIIf subfamily of basic helix-loop-helix transcription factor AtMYC1 leads to trichome and root hair patterning defects by abolishing its interaction with partner proteins in Arabidopsis.","URL":null,"raw_pages":"14109-21","medline_journal":"J Biol Chem","ISO_journal":"J Biol Chem","authors":["Zhao H","Wang X","Zhu D","Cui S","Li X","Cao Y","Ma L."],"DOI_URL":null}},"set_info":null,"overlaps_with":[{"accession":"IPR036638","name":"Helix-loop-helix DNA-binding domain superfamily","type":"homologous_superfamily"}],"counters":{"subfamilies":0,"domain_architectures":0,"interactions":0,"matches":994,"pathways":0,"proteins":988,"proteomes":340,"sets":0,"structural_models":{"alphafold":856,"bfvd":0},"structures":0,"taxa":999},"entry_annotations":{},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}