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{
"metadata": {
"accession": "IPR045896",
"entry_id": null,
"type": "domain",
"go_terms": null,
"source_database": "interpro",
"member_databases": {
"cdd": {
"cd18918": "basic Helix-Loop-Helix (bHLH) domain found in Arabidopsis thaliana MYC1 and similar proteins"
}
},
"integrated": null,
"hierarchy": {
"accession": "IPR011598",
"name": "Myc-type, basic helix-loop-helix (bHLH) domain",
"type": "Domain",
"children": [
{
"accession": "IPR015789",
"name": "Twist-related, basic helix-loop-helix domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR024098",
"name": "Transcription factor EB, bHLHzip domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR024100",
"name": "Transcription factor E3, bHLHzip domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR032644",
"name": "Transcription factor HES-7, basic helix-loop-helix-orange domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR032655",
"name": "Neurogenin-2, basic helix-loop-helix domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR032656",
"name": "Neurogenin-3, basic helix-loop-helix domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR032657",
"name": "Oligodendrocyte transcription factor 1, basic helix-loop-helix domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR032658",
"name": "Oligodendrocyte transcription factor 2, basic helix-loop-helix domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR032659",
"name": "Oligodendrocyte transcription factor 3, basic helix-loop-helix domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR032660",
"name": "Transcription factor ATOH8, basic helix-loop-helix domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR032661",
"name": "Transcription factor ATOH1, basic helix-loop-helix domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR033348",
"name": "Aryl hydrocarbon receptor, basic helix-loop-helix domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR039092",
"name": "Aryl hydrocarbon receptor repressor, basic helix-loop-helix domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR040106",
"name": "Protein Esc1, basic helix-loop-helix-zipper domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR045239",
"name": "Transcription factor bHLH95-like, basic helix-loop-helix domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR045896",
"name": "Transcription factor MYC1-like, bHLH domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR047093",
"name": "Twist-related protein 1, basic helix-loop-helix domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR047094",
"name": "Twist-related protein 2, basic helix-loop-helix domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR047206",
"name": "Centromere-binding protein 1-like, bHLHzip domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR047265",
"name": "Transcription factor PIF1-like, basic helix-loop-helix domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR048064",
"name": "Upstream transcription factor 3, basic helix-loop-helix domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR056192",
"name": "NPAS4, bHLH domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR056193",
"name": "Nuclear receptor coactivator 1-3, bHLH domain",
"type": "Domain",
"children": [
{
"accession": "IPR028819",
"name": "Nuclear receptor coactivator 1, basic helix-loop-helix",
"type": "Domain",
"children": []
},
{
"accession": "IPR028822",
"name": "Nuclear receptor coactivator 2, basic helix-loop-helix",
"type": "Domain",
"children": []
},
{
"accession": "IPR056194",
"name": "Nuclear receptor coactivator 3, basic helix-loop-helix",
"type": "Domain",
"children": []
}
]
},
{
"accession": "IPR057071",
"name": "INO2 bHLH domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR057072",
"name": "INO4, bHLH domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR057075",
"name": "Iron-related transcription factor 3, bHLH domain",
"type": "Domain",
"children": []
}
]
},
"name": {
"name": "Transcription factor MYC1-like, bHLH domain",
"short": "MYC1-like_bHLH"
},
"description": [
{
"text": "<p>This entry represents the basic helix-loop-helix (bHLH) domain found in a group of plant transcription factors. This entry includes MYC1 and bHLH91 from Arabidopsis thaliana and EAT1 from Oryza sativa.</p>\n\n<p>MYC1 (also known as BHLH12) is an important regulator of trichome and root hair initiation [[cite:PUB00099223]].</p>\n\n<p>bHLH91 is involved in pollen development. This protein is important for the normal transcriptome of the developing Arabidopsis anther, possibly by forming a feed-forward loop with DYT1 [[cite:PUB00099219], [cite:PUB00099220]].</p>\n\n<p>EAT1 participates in the regulation of tapetum programmed cell death (PCD) and degradation during male reproductive development in rice [[cite:PUB00099221], [cite:PUB00099222]].</p>",
"llm": false,
"checked": false,
"updated": false
}
],
"wikipedia": null,
"literature": {
"PUB00099219": {
"PMID": 33393464,
"ISBN": null,
"volume": "47",
"issue": "8",
"year": 2020,
"title": "Analyses of functional conservation and divergence reveal requirement of bHLH010/089/091 for pollen development at elevated temperature in Arabidopsis.",
"URL": null,
"raw_pages": "477-492",
"medline_journal": "J Genet Genomics",
"ISO_journal": "J Genet Genomics",
"authors": [
"Fu Y",
"Li M",
"Zhang S",
"Yang Q",
"Zhu E",
"You C",
"Qi J",
"Ma H",
"Chang F."
],
"DOI_URL": null
},
"PUB00099220": {
"PMID": 26216374,
"ISBN": null,
"volume": "83",
"issue": "6",
"year": 2015,
"title": "The DYT1-interacting proteins bHLH010, bHLH089 and bHLH091 are redundantly required for Arabidopsis anther development and transcriptome.",
"URL": null,
"raw_pages": "976-90",
"medline_journal": "Plant J",
"ISO_journal": "Plant J",
"authors": [
"Zhu E",
"You C",
"Wang S",
"Cui J",
"Niu B",
"Wang Y",
"Qi J",
"Ma H",
"Chang F."
],
"DOI_URL": null
},
"PUB00099221": {
"PMID": 23519457,
"ISBN": null,
"volume": "6",
"issue": "5",
"year": 2013,
"title": "A novel rice bHLH transcription factor, DTD, acts coordinately with TDR in controlling tapetum function and pollen development.",
"URL": null,
"raw_pages": "1715-8",
"medline_journal": "Mol Plant",
"ISO_journal": "Mol Plant",
"authors": [
"Ji C",
"Li H",
"Chen L",
"Xie M",
"Wang F",
"Chen Y",
"Liu YG."
],
"DOI_URL": null
},
"PUB00099222": {
"PMID": 23385589,
"ISBN": null,
"volume": "4",
"issue": null,
"year": 2013,
"title": "EAT1 promotes tapetal cell death by regulating aspartic proteases during male reproductive development in rice.",
"URL": null,
"raw_pages": "1445",
"medline_journal": "Nat Commun",
"ISO_journal": "Nat Commun",
"authors": [
"Niu N",
"Liang W",
"Yang X",
"Jin W",
"Wilson ZA",
"Hu J",
"Zhang D."
],
"DOI_URL": null
},
"PUB00099223": {
"PMID": 22334670,
"ISBN": null,
"volume": "287",
"issue": "17",
"year": 2012,
"title": "A single amino acid substitution in IIIf subfamily of basic helix-loop-helix transcription factor AtMYC1 leads to trichome and root hair patterning defects by abolishing its interaction with partner proteins in Arabidopsis.",
"URL": null,
"raw_pages": "14109-21",
"medline_journal": "J Biol Chem",
"ISO_journal": "J Biol Chem",
"authors": [
"Zhao H",
"Wang X",
"Zhu D",
"Cui S",
"Li X",
"Cao Y",
"Ma L."
],
"DOI_URL": null
}
},
"set_info": null,
"overlaps_with": [
{
"accession": "IPR036638",
"name": "Helix-loop-helix DNA-binding domain superfamily",
"type": "homologous_superfamily"
}
],
"counters": {
"subfamilies": 0,
"domain_architectures": 0,
"interactions": 0,
"matches": 994,
"pathways": 0,
"proteins": 988,
"proteomes": 340,
"sets": 0,
"structural_models": {
"alphafold": 856,
"bfvd": 0
},
"structures": 0,
"taxa": 999
},
"entry_annotations": {},
"cross_references": {},
"is_llm": false,
"is_reviewed_llm": false,
"is_updated_llm": false,
"representative_structure": null
}
}
