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{
"metadata": {
"accession": "IPR045267",
"entry_id": null,
"type": "domain",
"go_terms": [
{
"identifier": "GO:0004674",
"name": "protein serine/threonine kinase activity",
"category": {
"code": "F",
"name": "molecular_function"
}
},
{
"identifier": "GO:0005524",
"name": "ATP binding",
"category": {
"code": "F",
"name": "molecular_function"
}
},
{
"identifier": "GO:0006468",
"name": "protein phosphorylation",
"category": {
"code": "P",
"name": "biological_process"
}
}
],
"source_database": "interpro",
"member_databases": {
"cdd": {
"cd07843": "Catalytic domain of the Serine/Threonine Kinase, Cell Division Cycle 2-like 1"
}
},
"integrated": null,
"hierarchy": {
"accession": "IPR000719",
"name": "Protein kinase domain",
"type": "Domain",
"children": [
{
"accession": "IPR001245",
"name": "Serine-threonine/tyrosine-protein kinase, catalytic domain",
"type": "Domain",
"children": [
{
"accession": "IPR020635",
"name": "Tyrosine-protein kinase, catalytic domain",
"type": "Domain",
"children": [
{
"accession": "IPR028174",
"name": "Fibroblast growth factor receptor 1, catalytic domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR035588",
"name": "Janus kinase 2, pseudokinase domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR035589",
"name": "Janus kinase 2, catalytic domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR042785",
"name": "Tyrosine-protein kinase ITK/TSK, catalytic domain",
"type": "Domain",
"children": []
}
]
},
{
"accession": "IPR035692",
"name": "Integrin-linked protein kinase, pseudokinase domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR042817",
"name": "Serine/threonine-protein kinase LMTK1, catalytic domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR042822",
"name": "Membrane Guanylate Cyclase receptor GC-C, pseudokinase domain",
"type": "Domain",
"children": []
}
]
},
{
"accession": "IPR015725",
"name": "Myosin Light Chain Kinase 1, Kinase domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR020676",
"name": "Death-associated protein kinase 1, catalytic domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR024105",
"name": "Tribbles homologue 1, pseudokinase domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR026611",
"name": "Serine/threonine-protein kinase MRCK alpha, catalytic domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR027084",
"name": "Protein kinase Mps1 family, catalytic domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR027916",
"name": "Rhoptry, Protein kinase-like domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR028754",
"name": "Serine/threonine-protein kinase PAK5, catalytic domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR029878",
"name": "Rho-associated protein kinase 2, catalytic domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR030611",
"name": "Aurora kinase A",
"type": "Domain",
"children": []
},
{
"accession": "IPR033702",
"name": "Polo-like kinase 1, catalytic domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR034661",
"name": "Atypical protein kinase C iota type, catalytic domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR034668",
"name": "Novel protein kinase C theta, catalytic domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR034670",
"name": "Checkpoint kinase 1, catalytic domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR034671",
"name": "Hormonally up-regulated neu tumour-associated kinase, catalytic domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR034672",
"name": "Salt-Inducible kinase, catalytic domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR034673",
"name": "Maternal embryonic leucine zipper kinase, catalytic domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR034674",
"name": "Serine/threonine-protein kinase Kin4/ppk1, catalytic domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR035014",
"name": "cGMP-dependent protein kinase, catalytic domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR035053",
"name": "RPK118-like, kinase domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR035056",
"name": "MST4, kinase domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR035060",
"name": "Serine/threonine kinase 25, catalytic domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR035062",
"name": "Kic1p-like serine/threonine kinase, catalytic domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR035063",
"name": "p21-activated kinase 3, catalytic domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR035064",
"name": "p21-activated kinase 2, catalytic domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR035066",
"name": "Serine/threonine-protein kinase PAK 6, catalytic domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR037638",
"name": "Serine/threonine-protein kinase greatwall, catalytic domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR037711",
"name": "Microtubule-associated serine/threonine-protein kinase, catalytic domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR037716",
"name": "Rhodopsin kinase, catalytic domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR039154",
"name": "Serine/Threonine kinase LKB1, catalytic domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR039192",
"name": "Glycogen synthase kinase 3, catalytic domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR040110",
"name": "PINK1, protein kinase domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR041905",
"name": "Ribosomal protein S6 kinase alpha-3, C-terminal catalytic domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR041906",
"name": "Ribosomal S6 kinase, N-terminal catalytic domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR041989",
"name": "TOPK, catalytic domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR042666",
"name": "Serine/threonine-protein kinase Nek10, catalytic domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR042696",
"name": "Calcium/calmodulin-dependent protein kinase type 1B, catalytic domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR042697",
"name": "Nuclear receptor-binding protein 2, pseudokinase domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR042698",
"name": "Interleukin-1 receptor-associated kinase 3, pseudokinase domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR042703",
"name": "Serine/threonine-protein kinase PLK3, catalytic domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR042704",
"name": "Serine/threonine-protein kinase 17A, catalytic domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR042706",
"name": "Serine/threonine-protein kinase LATS1, catalytic domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR042709",
"name": "Testis-specific serine/threonine-protein kinase 3, catalytic domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR042710",
"name": "Testis-specific serine/threonine-protein kinase 6, catalytic domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR042714",
"name": "Tau-tubulin kinase 1, catalytic domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR042717",
"name": "Myosin light chain kinase 2, catalytic domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR042718",
"name": "Serine/threonine-protein kinase MRCK beta, catalytic domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR042743",
"name": "Serine/threonine-protein kinase 10, catalytic domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR042761",
"name": "CDK15, catalytic domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR042763",
"name": "Serine/threonine-protein kinase 17B, catalytic domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR042766",
"name": "RSK3, C-terminal catalytic domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR042767",
"name": "Serine/threonine-protein kinase Nek9, catalytic domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR042787",
"name": "M3K14, catalytic domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR042825",
"name": "PLK2, catalytic domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR042870",
"name": "DAPK3, catalytic domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR044092",
"name": "Serine/threonine-protein PRP4, catalytic domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR044093",
"name": "Cyclin-dependent kinase 10, catalytic domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR044120",
"name": "Nek8, catalytic domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR044131",
"name": "Dual specificity tyrosine-phosphorylation-regulated kinase 1A/1B, catalytic domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR045067",
"name": "Wee1-like protein kinase, catalytic domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR045267",
"name": "Cyclin-dependent kinase 11/PITSLRE, catalytic domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR045270",
"name": "Serine/Threonine Kinase AGC, catalytic domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR047908",
"name": "Testis-specific serine/threonine kinase 4, catalytic domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR047915",
"name": "Tau-Tubulin Kinase 2, catalytic domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR047916",
"name": "Tau-tubulin kinase homolog Asator-like, catalytic domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR048002",
"name": "Cyclin-dependent kinase 20-like, catalytic domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR049508",
"name": "Serine/threonine-protein kinase MARK 1-4, catalytic domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR049571",
"name": "Serine/threonine kinase NIM1, catalytic domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR049613",
"name": "Byr1-like, catalytic domain",
"type": "Domain",
"children": []
}
]
},
"name": {
"name": "Cyclin-dependent kinase 11/PITSLRE, catalytic domain",
"short": "CDK11/PITSLRE_STKc"
},
"description": [
{
"text": "<p>This entry represents the catalytic domain found in a group of cyclin-dependent kinases, including CDK11A/B from humans, CDKG1 from Arabidopsis, Ppk23 from fission yeasts and PITSLRE from Drosophila melanogaster. CDK11 has three isoforms that show peculiar expression patterns: the largest, mid-sized, and smallest isoforms of CDK11 are designated as CDK11/p110, CDK11/p58, and CDK11/p46, respectively. CDK11/p58, included in this entry, is translated from the same mRNA as CDK11/p110 and is expressed only during G2 and M phases. CDK11/p58 facilitates M phase progression by promoting centrosome maturation and bipolar spindle formation [[cite:PUB00098417], [cite:PUB00098418]]. CDKG1 regulates pre-mRNA splicing of CALLOSE SYNTHASE5 (CalS5) and, therefore, pollen wall formation [[cite:PUB00098420]]. It is also part of the CDKG1/CYCLINL complex is essential for synapsis and recombination during male meiosis [[cite:PUB00098419]].</p>",
"llm": false,
"checked": false,
"updated": false
}
],
"wikipedia": null,
"literature": {
"PUB00098419": {
"PMID": 24469829,
"ISBN": null,
"volume": "111",
"issue": "6",
"year": 2014,
"title": "CDKG1 protein kinase is essential for synapsis and male meiosis at high ambient temperature in Arabidopsis thaliana.",
"URL": null,
"raw_pages": "2182-7",
"medline_journal": "Proc Natl Acad Sci U S A",
"ISO_journal": "Proc Natl Acad Sci U S A",
"authors": [
"Zheng T",
"Nibau C",
"Phillips DW",
"Jenkins G",
"Armstrong SJ",
"Doonan JH."
],
"DOI_URL": null
},
"PUB00098420": {
"PMID": 23404887,
"ISBN": null,
"volume": "25",
"issue": "2",
"year": 2013,
"title": "CYCLIN-DEPENDENT KINASE G1 is associated with the spliceosome to regulate CALLOSE SYNTHASE5 splicing and pollen wall formation in Arabidopsis.",
"URL": null,
"raw_pages": "637-48",
"medline_journal": "Plant Cell",
"ISO_journal": "Plant Cell",
"authors": [
"Huang XY",
"Niu J",
"Sun MX",
"Zhu J",
"Gao JF",
"Yang J",
"Zhou Q",
"Yang ZN."
],
"DOI_URL": null
},
"PUB00098417": {
"PMID": 16462731,
"ISBN": null,
"volume": "7",
"issue": "4",
"year": 2006,
"title": "The PITSLRE/CDK11p58 protein kinase promotes centrosome maturation and bipolar spindle formation.",
"URL": null,
"raw_pages": "418-24",
"medline_journal": "EMBO Rep",
"ISO_journal": "EMBO Rep",
"authors": [
"Petretti C",
"Savoian M",
"Montembault E",
"Glover DM",
"Prigent C",
"Giet R."
],
"DOI_URL": null
},
"PUB00098418": {
"PMID": 17606997,
"ISBN": null,
"volume": "120",
"issue": "Pt 14",
"year": 2007,
"title": "CDK11(p58) is required for the maintenance of sister chromatid cohesion.",
"URL": null,
"raw_pages": "2424-34",
"medline_journal": "J Cell Sci",
"ISO_journal": "J Cell Sci",
"authors": [
"Hu D",
"Valentine M",
"Kidd VJ",
"Lahti JM."
],
"DOI_URL": null
}
},
"set_info": null,
"overlaps_with": [
{
"accession": "IPR011009",
"name": "Protein kinase-like domain superfamily",
"type": "homologous_superfamily"
}
],
"counters": {
"subfamilies": 0,
"domain_architectures": 0,
"interactions": 0,
"matches": 4951,
"pathways": 3,
"proteins": 4948,
"proteomes": 2143,
"sets": 0,
"structural_models": {
"alphafold": 4352,
"bfvd": 0
},
"structures": 2,
"taxa": 6511
},
"entry_annotations": {},
"cross_references": {
"ec": {
"displayName": "ENZYME",
"description": "ENZYME is a repository of information relative to the nomenclature of enzymes. It is primarily based on the recommendations of the Nomenclature Committee of the International Union of Biochemistry and Molecular Biology (IUBMB) and it describes each type of characterized enzyme for which an EC (Enzyme Commission) number has been provided.",
"rank": 19,
"accessions": [
{
"accession": "2.7.11.22",
"url": "https://enzyme.expasy.org/EC/2.7.11.22"
},
{
"accession": "2.7.11.23",
"url": "https://enzyme.expasy.org/EC/2.7.11.23"
}
]
}
},
"is_llm": false,
"is_reviewed_llm": false,
"is_updated_llm": false,
"representative_structure": null
}
}
