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{
    "metadata": {
        "accession": "IPR044460",
        "entry_id": null,
        "type": "domain",
        "go_terms": [
            {
                "identifier": "GO:0003723",
                "name": "RNA binding",
                "category": {
                    "code": "F",
                    "name": "molecular_function"
                }
            }
        ],
        "source_database": "interpro",
        "member_databases": {
            "cdd": {
                "cd19896": "first double-stranded RNA binding motif of RNA-editing deaminase 2 (RED2) and similar proteins"
            }
        },
        "integrated": null,
        "hierarchy": {
            "accession": "IPR044460",
            "name": "ADAR3, first double-stranded RNA binding domain",
            "type": "Domain",
            "children": []
        },
        "name": {
            "name": "ADAR3, first double-stranded RNA binding domain",
            "short": "ADAR3_DSRM_1"
        },
        "description": [
            {
                "text": "<p>Adenosine-to-inosine (A-to-I) editing is a post-transcriptional modification of RNA which changes its sequence, coding potential and secondary structure.  This reaction is catalysed by the adenosine deaminase acting on RNA (ADAR) proteins, ADAR1 and ADAR2 [[cite:PUB00096085]]. ADAR3 (also known as RED2 or ADARB2) prevents the binding of other ADAR enzymes to targets in vitro, and decreases the efficiency of these enzymes. It is capable of binding to both dsRNA and ssRNA. Moreover, ADAR3 lacks editing activity for currently known substrate RNAs, and may have an inactive editase domain. [[cite:PUB00096087]].</p>",
                "llm": false,
                "checked": false,
                "updated": false
            },
            {
                "text": "<p>ADAR3 contains two double-stranded RNA binding motifs (DSRMs) and a C-terminal RNA-specific adenosine-deaminase (editase) domain. This entry describes the first DSRM.</p>",
                "llm": false,
                "checked": false,
                "updated": false
            }
        ],
        "wikipedia": null,
        "literature": {
            "PUB00096085": {
                "PMID": 32603639,
                "ISBN": null,
                "volume": "10",
                "issue": "7",
                "year": 2020,
                "title": "What do editors do? Understanding the physiological functions of A-to-I RNA editing by adenosine deaminase acting on RNAs.",
                "URL": null,
                "raw_pages": "200085",
                "medline_journal": "Open Biol",
                "ISO_journal": "Open Biol",
                "authors": [
                    "Heraud-Farlow JE",
                    "Walkley CR."
                ],
                "DOI_URL": null
            },
            "PUB00096087": {
                "PMID": 10836796,
                "ISBN": null,
                "volume": "6",
                "issue": "5",
                "year": 2000,
                "title": "A third member of the RNA-specific adenosine deaminase gene family, ADAR3, contains both single- and double-stranded RNA binding domains.",
                "URL": null,
                "raw_pages": "755-67",
                "medline_journal": "RNA",
                "ISO_journal": "RNA",
                "authors": [
                    "Chen CX",
                    "Cho DS",
                    "Wang Q",
                    "Lai F",
                    "Carter KC",
                    "Nishikura K."
                ],
                "DOI_URL": null
            }
        },
        "set_info": null,
        "overlaps_with": null,
        "counters": {
            "subfamilies": 0,
            "domain_architectures": 0,
            "interactions": 0,
            "matches": 1029,
            "pathways": 0,
            "proteins": 1029,
            "proteomes": 622,
            "sets": 0,
            "structural_models": {
                "alphafold": 952,
                "bfvd": 0
            },
            "structures": 0,
            "taxa": 1966
        },
        "entry_annotations": {},
        "cross_references": {},
        "is_llm": false,
        "is_reviewed_llm": false,
        "is_updated_llm": false,
        "representative_structure": null
    }
}