{"metadata":{"accession":"IPR043681","entry_id":null,"type":"family","go_terms":[{"identifier":"GO:0072344","name":"rescue of stalled cytosolic ribosome","category":{"code":"P","name":"biological_process"}}],"source_database":"interpro","member_databases":{"hamap":{"MF_00844_A":"Rqc2 homolog RqcH [rqcH]"}},"integrated":null,"hierarchy":{"accession":"IPR043681","name":"Rqc2 homolog RqcH, archaeal","type":"Family","children":[]},"name":{"name":"Rqc2 homolog RqcH, archaeal","short":"RqcH_archaeal"},"description":[{"text":"<p>Ribosome-associated protein quality control (RQC) sense ribosome stalling during translation and mediate subunit recycling and nascent-chain proteolysis. Rqc2 is one of the eukaryotic sense factors of ribosomal obstruction and recruits the E3 ligase Ltn1/Listerin for ubiquitination and proteasome degradation. When this mechanism fails, it adds a poly-Alanine chain to promote its destruction. Bacterial and archaeal homologues, namely RqcH add a poly-Ala chain to the aberrant nascent chain in the large ribosome subunit and tag it for degradation [[cite:PUB00094456]].</p>","llm":false,"checked":false,"updated":false},{"text":"<p>This entry represents the Rqc2 homologue (RqcH) from archaea.</p>","llm":false,"checked":false,"updated":false}],"wikipedia":null,"literature":{"PUB00094456":{"PMID":31155236,"ISBN":null,"volume":"178","issue":"1","year":2019,"title":"Alanine Tails Signal Proteolysis in Bacterial Ribosome-Associated Quality Control.","URL":null,"raw_pages":"76-90.e22","medline_journal":"Cell","ISO_journal":"Cell","authors":["Lytvynenko I","Paternoga H","Thrun A","Balke A","Muller TA","Chiang CH","Nagler K","Tsaprailis G","Anders S","Bischofs I","Maupin-Furlow JA","Spahn CMT","Joazeiro CAP."],"DOI_URL":null}},"set_info":null,"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":0,"interactions":0,"matches":537,"pathways":0,"proteins":537,"proteomes":406,"sets":0,"structural_models":{"alphafold":519,"bfvd":0},"structures":0,"taxa":715},"entry_annotations":{},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}