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{
    "metadata": {
        "accession": "IPR043681",
        "entry_id": null,
        "type": "family",
        "go_terms": [
            {
                "identifier": "GO:0072344",
                "name": "rescue of stalled cytosolic ribosome",
                "category": {
                    "code": "P",
                    "name": "biological_process"
                }
            }
        ],
        "source_database": "interpro",
        "member_databases": {
            "hamap": {
                "MF_00844_A": "Rqc2 homolog RqcH [rqcH]"
            }
        },
        "integrated": null,
        "hierarchy": {
            "accession": "IPR043681",
            "name": "Rqc2 homolog RqcH, archaeal",
            "type": "Family",
            "children": []
        },
        "name": {
            "name": "Rqc2 homolog RqcH, archaeal",
            "short": "RqcH_archaeal"
        },
        "description": [
            {
                "text": "<p>Ribosome-associated protein quality control (RQC) sense ribosome stalling during translation and mediate subunit recycling and nascent-chain proteolysis. Rqc2 is one of the eukaryotic sense factors of ribosomal obstruction and recruits the E3 ligase Ltn1/Listerin for ubiquitination and proteasome degradation. When this mechanism fails, it adds a poly-Alanine chain to promote its destruction. Bacterial and archaeal homologues, namely RqcH add a poly-Ala chain to the aberrant nascent chain in the large ribosome subunit and tag it for degradation [[cite:PUB00094456]].</p>",
                "llm": false,
                "checked": false,
                "updated": false
            },
            {
                "text": "<p>This entry represents the Rqc2 homologue (RqcH) from archaea.</p>",
                "llm": false,
                "checked": false,
                "updated": false
            }
        ],
        "wikipedia": null,
        "literature": {
            "PUB00094456": {
                "PMID": 31155236,
                "ISBN": null,
                "volume": "178",
                "issue": "1",
                "year": 2019,
                "title": "Alanine Tails Signal Proteolysis in Bacterial Ribosome-Associated Quality Control.",
                "URL": null,
                "raw_pages": "76-90.e22",
                "medline_journal": "Cell",
                "ISO_journal": "Cell",
                "authors": [
                    "Lytvynenko I",
                    "Paternoga H",
                    "Thrun A",
                    "Balke A",
                    "Muller TA",
                    "Chiang CH",
                    "Nagler K",
                    "Tsaprailis G",
                    "Anders S",
                    "Bischofs I",
                    "Maupin-Furlow JA",
                    "Spahn CMT",
                    "Joazeiro CAP."
                ],
                "DOI_URL": null
            }
        },
        "set_info": null,
        "overlaps_with": null,
        "counters": {
            "subfamilies": 0,
            "domain_architectures": 0,
            "interactions": 0,
            "matches": 537,
            "pathways": 0,
            "proteins": 537,
            "proteomes": 406,
            "sets": 0,
            "structural_models": {
                "alphafold": 519,
                "bfvd": 0
            },
            "structures": 0,
            "taxa": 715
        },
        "entry_annotations": {},
        "cross_references": {},
        "is_llm": false,
        "is_reviewed_llm": false,
        "is_updated_llm": false,
        "representative_structure": null
    }
}