{"metadata":{"accession":"IPR042706","entry_id":null,"type":"domain","go_terms":[{"identifier":"GO:0004674","name":"protein serine/threonine kinase activity","category":{"code":"F","name":"molecular_function"}}],"source_database":"interpro","member_databases":{"cdd":{"cd05625":"Catalytic domain of the Serine/Threonine Kinase, Large Tumor Suppressor 1"}},"integrated":null,"hierarchy":{"accession":"IPR000719","name":"Protein kinase domain","type":"Domain","children":[{"accession":"IPR001245","name":"Serine-threonine/tyrosine-protein kinase, catalytic domain","type":"Domain","children":[{"accession":"IPR020635","name":"Tyrosine-protein kinase, catalytic domain","type":"Domain","children":[{"accession":"IPR028174","name":"Fibroblast growth factor receptor 1, catalytic domain","type":"Domain","children":[]},{"accession":"IPR035588","name":"Janus kinase 2, pseudokinase domain","type":"Domain","children":[]},{"accession":"IPR035589","name":"Janus kinase 2, catalytic 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catalytic domain","type":"Domain","children":[]},{"accession":"IPR035063","name":"p21-activated kinase 3, catalytic domain","type":"Domain","children":[]},{"accession":"IPR035064","name":"p21-activated kinase 2, catalytic domain","type":"Domain","children":[]},{"accession":"IPR035066","name":"Serine/threonine-protein kinase PAK 6, catalytic domain","type":"Domain","children":[]},{"accession":"IPR037638","name":"Serine/threonine-protein kinase greatwall, catalytic domain","type":"Domain","children":[]},{"accession":"IPR037711","name":"Microtubule-associated serine/threonine-protein kinase, catalytic domain","type":"Domain","children":[]},{"accession":"IPR037716","name":"Rhodopsin kinase, catalytic domain","type":"Domain","children":[]},{"accession":"IPR039154","name":"Serine/Threonine kinase LKB1, catalytic domain","type":"Domain","children":[]},{"accession":"IPR039192","name":"Glycogen synthase kinase 3, catalytic domain","type":"Domain","children":[]},{"accession":"IPR040110","name":"PINK1, protein kinase domain","type":"Domain","children":[]},{"accession":"IPR041905","name":"Ribosomal protein S6 kinase alpha-3, C-terminal catalytic domain","type":"Domain","children":[]},{"accession":"IPR041906","name":"Ribosomal S6 kinase, N-terminal catalytic domain","type":"Domain","children":[]},{"accession":"IPR041989","name":"TOPK, catalytic domain","type":"Domain","children":[]},{"accession":"IPR042666","name":"Serine/threonine-protein kinase Nek10, catalytic domain","type":"Domain","children":[]},{"accession":"IPR042696","name":"Calcium/calmodulin-dependent protein kinase type 1B, catalytic domain","type":"Domain","children":[]},{"accession":"IPR042697","name":"Nuclear receptor-binding protein 2, pseudokinase domain","type":"Domain","children":[]},{"accession":"IPR042698","name":"Interleukin-1 receptor-associated kinase 3, pseudokinase domain","type":"Domain","children":[]},{"accession":"IPR042703","name":"Serine/threonine-protein kinase PLK3, catalytic domain","type":"Domain","children":[]},{"accession":"IPR042704","name":"Serine/threonine-protein kinase 17A, catalytic domain","type":"Domain","children":[]},{"accession":"IPR042706","name":"Serine/threonine-protein kinase LATS1, catalytic domain","type":"Domain","children":[]},{"accession":"IPR042709","name":"Testis-specific serine/threonine-protein kinase 3, catalytic domain","type":"Domain","children":[]},{"accession":"IPR042710","name":"Testis-specific serine/threonine-protein kinase 6, catalytic domain","type":"Domain","children":[]},{"accession":"IPR042714","name":"Tau-tubulin kinase 1, catalytic domain","type":"Domain","children":[]},{"accession":"IPR042717","name":"Myosin light chain kinase 2, catalytic domain","type":"Domain","children":[]},{"accession":"IPR042718","name":"Serine/threonine-protein kinase MRCK beta, catalytic domain","type":"Domain","children":[]},{"accession":"IPR042743","name":"Serine/threonine-protein kinase 10, catalytic domain","type":"Domain","children":[]},{"accession":"IPR042761","name":"CDK15, catalytic domain","type":"Domain","children":[]},{"accession":"IPR042763","name":"Serine/threonine-protein kinase 17B, catalytic domain","type":"Domain","children":[]},{"accession":"IPR042766","name":"RSK3, C-terminal catalytic domain","type":"Domain","children":[]},{"accession":"IPR042767","name":"Serine/threonine-protein kinase Nek9, catalytic domain","type":"Domain","children":[]},{"accession":"IPR042787","name":"M3K14, catalytic domain","type":"Domain","children":[]},{"accession":"IPR042825","name":"PLK2, catalytic domain","type":"Domain","children":[]},{"accession":"IPR042870","name":"DAPK3, catalytic domain","type":"Domain","children":[]},{"accession":"IPR044092","name":"Serine/threonine-protein PRP4, catalytic domain","type":"Domain","children":[]},{"accession":"IPR044093","name":"Cyclin-dependent kinase 10, catalytic domain","type":"Domain","children":[]},{"accession":"IPR044120","name":"Nek8, catalytic domain","type":"Domain","children":[]},{"accession":"IPR044131","name":"Dual specificity tyrosine-phosphorylation-regulated kinase 1A/1B, catalytic domain","type":"Domain","children":[]},{"accession":"IPR045067","name":"Wee1-like protein kinase, catalytic domain","type":"Domain","children":[]},{"accession":"IPR045267","name":"Cyclin-dependent kinase 11/PITSLRE, catalytic domain","type":"Domain","children":[]},{"accession":"IPR045270","name":"Serine/Threonine Kinase AGC, catalytic domain","type":"Domain","children":[]},{"accession":"IPR047908","name":"Testis-specific serine/threonine kinase 4, catalytic domain","type":"Domain","children":[]},{"accession":"IPR047915","name":"Tau-Tubulin Kinase 2, catalytic domain","type":"Domain","children":[]},{"accession":"IPR047916","name":"Tau-tubulin kinase homolog Asator-like, catalytic domain","type":"Domain","children":[]},{"accession":"IPR048002","name":"Cyclin-dependent kinase 20-like, catalytic domain","type":"Domain","children":[]},{"accession":"IPR049508","name":"Serine/threonine-protein kinase MARK 1-4, catalytic domain","type":"Domain","children":[]},{"accession":"IPR049571","name":"Serine/threonine kinase NIM1, catalytic domain","type":"Domain","children":[]},{"accession":"IPR049613","name":"Byr1-like, catalytic domain","type":"Domain","children":[]}]},"name":{"name":"Serine/threonine-protein kinase LATS1, catalytic domain","short":"LATS1_STKc"},"description":[{"text":"<p>STKs (serine/threonine-protein kinases) catalyse the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. LATS1 functions as a tumour suppressor and is implicated in cell cycle regulation [[cite:PUB00093186]]. Inactivation of LATS1 in mice results in the development of various tumours, including sarcomas and ovarian cancer [[cite:PUB00093187]]. Promoter methylation, loss of heterozygosity, and missense mutations targeting the LATS1 gene have also been found in human sarcomas and ovarian cancers. In addition, decreased expression of LATS1 is associated with an aggressive phenotype and poor prognosis [[cite:PUB00093189]. LATS1 induces G2 arrest and promotes cytokinesis. It may be a component of the mitotic exit network in higher eukaryotes [[cite:PUB00093186], [cite:PUB00093188], [cite:PUB00069142]].</p>","llm":false,"checked":false,"updated":false}],"wikipedia":null,"literature":{"PUB00093187":{"PMID":11850843,"ISBN":null,"volume":"21","issue":"8","year":2002,"title":"LATS1 tumor suppressor regulates G2/M transition and apoptosis.","URL":null,"raw_pages":"1233-41","medline_journal":"Oncogene","ISO_journal":"Oncogene","authors":["Xia H","Qi H","Li Y","Pei J","Barton J","Blackstad M","Xu T","Tao W."],"DOI_URL":null},"PUB00093186":{"PMID":11641775,"ISBN":null,"volume":"20","issue":"45","year":2001,"title":"Human homologue of Drosophila lats, LATS1, negatively regulate growth by inducing G(2)/M arrest or apoptosis.","URL":null,"raw_pages":"6516-23","medline_journal":"Oncogene","ISO_journal":"Oncogene","authors":["Yang X","Li DM","Chen W","Xu T."],"DOI_URL":null},"PUB00093188":{"PMID":15220930,"ISBN":null,"volume":"6","issue":"7","year":2004,"title":"LATS1 tumour suppressor affects cytokinesis by inhibiting LIMK1.","URL":null,"raw_pages":"609-17","medline_journal":"Nat Cell Biol","ISO_journal":"Nat. Cell Biol.","authors":["Yang X","Yu K","Hao Y","Li DM","Stewart R","Insogna KL","Xu T."],"DOI_URL":null},"PUB00069142":{"PMID":16061636,"ISBN":null,"volume":"65","issue":"15","year":2005,"title":"Human LATS1 is a mitotic exit network kinase.","URL":null,"raw_pages":"6568-75","medline_journal":"Cancer Res","ISO_journal":"Cancer Res.","authors":["Bothos J","Tuttle RL","Ottey M","Luca FC","Halazonetis TD."],"DOI_URL":"http://dx.doi.org/10.1158/0008-5472.CAN-05-0862"},"PUB00093189":{"PMID":15746036,"ISBN":null,"volume":"11","issue":"4","year":2005,"title":"Down-regulation of LATS1 and LATS2 mRNA expression by promoter hypermethylation and its association with biologically aggressive phenotype in human breast cancers.","URL":null,"raw_pages":"1380-5","medline_journal":"Clin Cancer Res","ISO_journal":"Clin. Cancer Res.","authors":["Takahashi Y","Miyoshi Y","Takahata C","Irahara N","Taguchi T","Tamaki Y","Noguchi S."],"DOI_URL":null}},"set_info":null,"overlaps_with":[{"accession":"IPR011009","name":"Protein kinase-like domain superfamily","type":"homologous_superfamily"}],"counters":{"subfamilies":0,"domain_architectures":0,"interactions":0,"matches":222,"pathways":2,"proteins":222,"proteomes":164,"sets":0,"structural_models":{"alphafold":187,"bfvd":0},"structures":0,"taxa":569},"entry_annotations":{},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}