"accession"	"counters"	"cross_references"	"description"	"entry_id"	"go_terms"	"hierarchy"	"integrated"	"is_llm"	"is_reviewed_llm"	"is_updated_llm"	"literature"	"member_databases"	"name"	"overlaps_with"	"representative_structure"	"set_info"	"source_database"	"type"	"wikipedia"
"IPR042694"	"{'subfamilies': 0, 'domain_architectures': 0, 'interactions': 0, 'matches': 269, 'pathways': 0, 'proteins': 269, 'proteomes': 187, 'sets': 0, 'structural_models': {'alphafold': 237, 'bfvd': 0}, 'structures': 0, 'taxa': 668}"	"{}"	"[{'text': '<p>F-BAR domains are dimerization modules that bind and bend membranes and are found in proteins involved in membrane dynamics and actin reorganization [[cite:PUB00043263]]. Proline-Serine-Threonine Phosphatase-Interacting Protein 2 (PSTPIP2) is mostly expressed in hematopoietic cells but is also expressed in the brain. It is involved in regulating cell adhesion and motility [[cite:PUB00071674]]. Mutations in the gene encoding murine PSTPIP2 can cause autoinflammatory disorders such as chronic multifocal osteomyelitis and macrophage autoinflammatory disease [[cite:PUB00071675]]. PSTPIP2 contains an N-terminal F-BAR domain and lacks the PEST motifs and SH3 domain that are found in PSTPIP1. F-BAR domains form banana-shaped dimers with a positively-charged concave surface that binds to negatively-charged lipid membranes. They can induce membrane deformation in the form of long tubules [[cite:PUB00043263]].</p>', 'llm': False, 'checked': False, 'updated': False}]"	""	""	"{'accession': 'IPR031160', 'name': 'F-BAR domain', 'type': 'Domain', 'children': [{'accession': 'IPR034934', 'name': 'F-BAR and double SH3 domains protein 2, F-BAR domain', 'type': 'Domain', 'children': []}, {'accession': 'IPR035494', 'name': 'FNBP1L, F-BAR domain', 'type': 'Domain', 'children': []}, {'accession': 'IPR037449', 'name': 'Formin-binding protein 1, F-BAR domain', 'type': 'Domain', 'children': []}, {'accession': 'IPR037451', 'name': 'SLIT-ROBO Rho GTPase-activating protein 1, F-BAR domain', 'type': 'Domain', 'children': []}, {'accession': 'IPR037452', 'name': 'Tyrosine-protein kinase Fer, F-BAR domain', 'type': 'Domain', 'children': []}, {'accession': 'IPR037453', 'name': 'PACSIN2, F-BAR domain', 'type': 'Domain', 'children': []}, {'accession': 'IPR037454', 'name': 'PACSIN1, F-BAR', 'type': 'Domain', 'children': []}, {'accession': 'IPR037957', 'name': 'GAS7, F-BAR domain', 'type': 'Domain', 'children': []}, {'accession': 'IPR042694', 'name': 'Proline-serine-threonine phosphatase-interacting protein 2, F-BAR domain', 'type': 'Domain', 'children': []}, {'accession': 'IPR049581', 'name': 'Slit-Robo GTPase Activating Protein 3, F-BAR domain', 'type': 'Domain', 'children': []}, {'accession': 'IPR054713', 'name': 'GMIP/FCHO2-like, FCH domain', 'type': 'Domain', 'children': [{'accession': 'IPR030122', 'name': 'F-BAR domain only protein 2, F-BAR domain', 'type': 'Domain', 'children': []}, {'accession': 'IPR042735', 'name': 'FCHO1, F-BAR domain', 'type': 'Domain', 'children': []}]}]}"	""	False	False	False	"{'PUB00043263': {'PMID': 17540576, 'ISBN': None, 'volume': '15', 'issue': '7', 'year': 2007, 'title': 'Structure and analysis of FCHo2 F-BAR domain: a dimerizing and membrane recruitment module that effects membrane curvature.', 'URL': None, 'raw_pages': '839-52', 'medline_journal': 'Structure', 'ISO_journal': 'Structure', 'authors': ['Henne WM', 'Kent HM', 'Ford MG', 'Hegde BG', 'Daumke O', 'Butler PJ', 'Mittal R', 'Langen R', 'Evans PR', 'McMahon HT.'], 'DOI_URL': 'http://dx.doi.org/10.1016/j.str.2007.05.002'}, 'PUB00071675': {'PMID': 16397132, 'ISBN': None, 'volume': '107', 'issue': '8', 'year': 2006, 'title': 'Mutation of mouse Mayp/Pstpip2 causes a macrophage autoinflammatory disease.', 'URL': None, 'raw_pages': '3350-8', 'medline_journal': 'Blood', 'ISO_journal': 'Blood', 'authors': ['Grosse J', 'Chitu V', 'Marquardt A', 'Hanke P', 'Schmittwolf C', 'Zeitlmann L', 'Schropp P', 'Barth B', 'Yu P', 'Paffenholz R', 'Stumm G', 'Nehls M', 'Stanley ER.'], 'DOI_URL': 'http://dx.doi.org/10.1182/blood-2005-09-3556'}, 'PUB00071674': {'PMID': 15788569, 'ISBN': None, 'volume': '16', 'issue': '6', 'year': 2005, 'title': 'The PCH family member MAYP/PSTPIP2 directly regulates F-actin bundling and enhances filopodia formation and motility in macrophages.', 'URL': None, 'raw_pages': '2947-59', 'medline_journal': 'Mol Biol Cell', 'ISO_journal': 'Mol. Biol. Cell', 'authors': ['Chitu V', 'Pixley FJ', 'Macaluso F', 'Larson DR', 'Condeelis J', 'Yeung YG', 'Stanley ER.'], 'DOI_URL': 'http://dx.doi.org/10.1091/mbc.E04-10-0914'}}"	"{'cdd': {'cd07672': 'The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Proline-Serine-Threonine Phosphatase-Interacting Protein 2'}}"	"{'name': 'Proline-serine-threonine phosphatase-interacting protein 2, F-BAR domain', 'short': 'PSTPIP2_F-BAR'}"	"[{'accession': 'IPR027267', 'name': 'AH/BAR domain superfamily', 'type': 'homologous_superfamily'}]"	""	""	"interpro"	"domain"	""