{"metadata":{"accession":"IPR042694","entry_id":null,"type":"domain","go_terms":null,"source_database":"interpro","member_databases":{"cdd":{"cd07672":"The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Proline-Serine-Threonine Phosphatase-Interacting Protein 2"}},"integrated":null,"hierarchy":{"accession":"IPR031160","name":"F-BAR domain","type":"Domain","children":[{"accession":"IPR034934","name":"F-BAR and double SH3 domains protein 2, F-BAR domain","type":"Domain","children":[]},{"accession":"IPR035494","name":"FNBP1L, F-BAR domain","type":"Domain","children":[]},{"accession":"IPR037449","name":"Formin-binding protein 1, F-BAR domain","type":"Domain","children":[]},{"accession":"IPR037451","name":"SLIT-ROBO Rho GTPase-activating protein 1, F-BAR domain","type":"Domain","children":[]},{"accession":"IPR037452","name":"Tyrosine-protein kinase Fer, F-BAR domain","type":"Domain","children":[]},{"accession":"IPR037453","name":"PACSIN2, F-BAR domain","type":"Domain","children":[]},{"accession":"IPR037454","name":"PACSIN1, F-BAR","type":"Domain","children":[]},{"accession":"IPR037957","name":"GAS7, F-BAR domain","type":"Domain","children":[]},{"accession":"IPR042694","name":"Proline-serine-threonine phosphatase-interacting protein 2, F-BAR domain","type":"Domain","children":[]},{"accession":"IPR049581","name":"Slit-Robo GTPase Activating Protein 3, F-BAR domain","type":"Domain","children":[]},{"accession":"IPR054713","name":"GMIP/FCHO2-like, FCH domain","type":"Domain","children":[{"accession":"IPR030122","name":"F-BAR domain only protein 2, F-BAR domain","type":"Domain","children":[]},{"accession":"IPR042735","name":"FCHO1, F-BAR domain","type":"Domain","children":[]}]}]},"name":{"name":"Proline-serine-threonine phosphatase-interacting protein 2, F-BAR domain","short":"PSTPIP2_F-BAR"},"description":[{"text":"<p>F-BAR domains are dimerization modules that bind and bend membranes and are found in proteins involved in membrane dynamics and actin reorganization [[cite:PUB00043263]]. Proline-Serine-Threonine Phosphatase-Interacting Protein 2 (PSTPIP2) is mostly expressed in hematopoietic cells but is also expressed in the brain. It is involved in regulating cell adhesion and motility [[cite:PUB00071674]]. Mutations in the gene encoding murine PSTPIP2 can cause autoinflammatory disorders such as chronic multifocal osteomyelitis and macrophage autoinflammatory disease [[cite:PUB00071675]]. PSTPIP2 contains an N-terminal F-BAR domain and lacks the PEST motifs and SH3 domain that are found in PSTPIP1. F-BAR domains form banana-shaped dimers with a positively-charged concave surface that binds to negatively-charged lipid membranes. They can induce membrane deformation in the form of long tubules [[cite:PUB00043263]].</p>","llm":false,"checked":false,"updated":false}],"wikipedia":null,"literature":{"PUB00043263":{"PMID":17540576,"ISBN":null,"volume":"15","issue":"7","year":2007,"title":"Structure and analysis of FCHo2 F-BAR domain: a dimerizing and membrane recruitment module that effects membrane curvature.","URL":null,"raw_pages":"839-52","medline_journal":"Structure","ISO_journal":"Structure","authors":["Henne WM","Kent HM","Ford MG","Hegde BG","Daumke O","Butler PJ","Mittal R","Langen R","Evans PR","McMahon HT."],"DOI_URL":"http://dx.doi.org/10.1016/j.str.2007.05.002"},"PUB00071675":{"PMID":16397132,"ISBN":null,"volume":"107","issue":"8","year":2006,"title":"Mutation of mouse Mayp/Pstpip2 causes a macrophage autoinflammatory disease.","URL":null,"raw_pages":"3350-8","medline_journal":"Blood","ISO_journal":"Blood","authors":["Grosse J","Chitu V","Marquardt A","Hanke P","Schmittwolf C","Zeitlmann L","Schropp P","Barth B","Yu P","Paffenholz R","Stumm G","Nehls M","Stanley ER."],"DOI_URL":"http://dx.doi.org/10.1182/blood-2005-09-3556"},"PUB00071674":{"PMID":15788569,"ISBN":null,"volume":"16","issue":"6","year":2005,"title":"The PCH family member MAYP/PSTPIP2 directly regulates F-actin bundling and enhances filopodia formation and motility in macrophages.","URL":null,"raw_pages":"2947-59","medline_journal":"Mol Biol Cell","ISO_journal":"Mol. Biol. Cell","authors":["Chitu V","Pixley FJ","Macaluso F","Larson DR","Condeelis J","Yeung YG","Stanley ER."],"DOI_URL":"http://dx.doi.org/10.1091/mbc.E04-10-0914"}},"set_info":null,"overlaps_with":[{"accession":"IPR027267","name":"AH/BAR domain superfamily","type":"homologous_superfamily"}],"counters":{"subfamilies":0,"domain_architectures":0,"interactions":0,"matches":269,"pathways":0,"proteins":269,"proteomes":187,"sets":0,"structural_models":{"alphafold":237,"bfvd":0},"structures":0,"taxa":668},"entry_annotations":{},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}