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{
"metadata": {
"accession": "IPR042694",
"entry_id": null,
"type": "domain",
"go_terms": null,
"source_database": "interpro",
"member_databases": {
"cdd": {
"cd07672": "The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Proline-Serine-Threonine Phosphatase-Interacting Protein 2"
}
},
"integrated": null,
"hierarchy": {
"accession": "IPR031160",
"name": "F-BAR domain",
"type": "Domain",
"children": [
{
"accession": "IPR034934",
"name": "F-BAR and double SH3 domains protein 2, F-BAR domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR035494",
"name": "FNBP1L, F-BAR domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR037449",
"name": "Formin-binding protein 1, F-BAR domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR037451",
"name": "SLIT-ROBO Rho GTPase-activating protein 1, F-BAR domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR037452",
"name": "Tyrosine-protein kinase Fer, F-BAR domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR037453",
"name": "PACSIN2, F-BAR domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR037454",
"name": "PACSIN1, F-BAR",
"type": "Domain",
"children": []
},
{
"accession": "IPR037957",
"name": "GAS7, F-BAR domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR042694",
"name": "Proline-serine-threonine phosphatase-interacting protein 2, F-BAR domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR049581",
"name": "Slit-Robo GTPase Activating Protein 3, F-BAR domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR054713",
"name": "GMIP/FCHO2-like, FCH domain",
"type": "Domain",
"children": [
{
"accession": "IPR030122",
"name": "F-BAR domain only protein 2, F-BAR domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR042735",
"name": "FCHO1, F-BAR domain",
"type": "Domain",
"children": []
}
]
}
]
},
"name": {
"name": "Proline-serine-threonine phosphatase-interacting protein 2, F-BAR domain",
"short": "PSTPIP2_F-BAR"
},
"description": [
{
"text": "<p>F-BAR domains are dimerization modules that bind and bend membranes and are found in proteins involved in membrane dynamics and actin reorganization [[cite:PUB00043263]]. Proline-Serine-Threonine Phosphatase-Interacting Protein 2 (PSTPIP2) is mostly expressed in hematopoietic cells but is also expressed in the brain. It is involved in regulating cell adhesion and motility [[cite:PUB00071674]]. Mutations in the gene encoding murine PSTPIP2 can cause autoinflammatory disorders such as chronic multifocal osteomyelitis and macrophage autoinflammatory disease [[cite:PUB00071675]]. PSTPIP2 contains an N-terminal F-BAR domain and lacks the PEST motifs and SH3 domain that are found in PSTPIP1. F-BAR domains form banana-shaped dimers with a positively-charged concave surface that binds to negatively-charged lipid membranes. They can induce membrane deformation in the form of long tubules [[cite:PUB00043263]].</p>",
"llm": false,
"checked": false,
"updated": false
}
],
"wikipedia": null,
"literature": {
"PUB00043263": {
"PMID": 17540576,
"ISBN": null,
"volume": "15",
"issue": "7",
"year": 2007,
"title": "Structure and analysis of FCHo2 F-BAR domain: a dimerizing and membrane recruitment module that effects membrane curvature.",
"URL": null,
"raw_pages": "839-52",
"medline_journal": "Structure",
"ISO_journal": "Structure",
"authors": [
"Henne WM",
"Kent HM",
"Ford MG",
"Hegde BG",
"Daumke O",
"Butler PJ",
"Mittal R",
"Langen R",
"Evans PR",
"McMahon HT."
],
"DOI_URL": "http://dx.doi.org/10.1016/j.str.2007.05.002"
},
"PUB00071675": {
"PMID": 16397132,
"ISBN": null,
"volume": "107",
"issue": "8",
"year": 2006,
"title": "Mutation of mouse Mayp/Pstpip2 causes a macrophage autoinflammatory disease.",
"URL": null,
"raw_pages": "3350-8",
"medline_journal": "Blood",
"ISO_journal": "Blood",
"authors": [
"Grosse J",
"Chitu V",
"Marquardt A",
"Hanke P",
"Schmittwolf C",
"Zeitlmann L",
"Schropp P",
"Barth B",
"Yu P",
"Paffenholz R",
"Stumm G",
"Nehls M",
"Stanley ER."
],
"DOI_URL": "http://dx.doi.org/10.1182/blood-2005-09-3556"
},
"PUB00071674": {
"PMID": 15788569,
"ISBN": null,
"volume": "16",
"issue": "6",
"year": 2005,
"title": "The PCH family member MAYP/PSTPIP2 directly regulates F-actin bundling and enhances filopodia formation and motility in macrophages.",
"URL": null,
"raw_pages": "2947-59",
"medline_journal": "Mol Biol Cell",
"ISO_journal": "Mol. Biol. Cell",
"authors": [
"Chitu V",
"Pixley FJ",
"Macaluso F",
"Larson DR",
"Condeelis J",
"Yeung YG",
"Stanley ER."
],
"DOI_URL": "http://dx.doi.org/10.1091/mbc.E04-10-0914"
}
},
"set_info": null,
"overlaps_with": [
{
"accession": "IPR027267",
"name": "AH/BAR domain superfamily",
"type": "homologous_superfamily"
}
],
"counters": {
"subfamilies": 0,
"domain_architectures": 0,
"interactions": 0,
"matches": 269,
"pathways": 0,
"proteins": 269,
"proteomes": 187,
"sets": 0,
"structural_models": {
"alphafold": 237,
"bfvd": 0
},
"structures": 0,
"taxa": 668
},
"entry_annotations": {},
"cross_references": {},
"is_llm": false,
"is_reviewed_llm": false,
"is_updated_llm": false,
"representative_structure": null
}
}
