This entry represents the PX domain found in Sorting nexin-3 (SNX3) from vertebrates. In budding yeasts, Snx3 homologue has been shown to associate with early endosomes through a PX domain-mediated interaction with phosphatidylinositol-3-phosphate (PI3P) [[cite:PUB00029398]]. It associates with the retromer complex, a membrane coat multimeric complex required for endosomal retrieval of lysosomal hydrolase receptors to the Golgi, and functions as a cargo-specific adaptor for the retromer. SNX3 is required for the formation of multivesicular bodies, which function as transport intermediates to late endosomes [[cite:PUB00092707], [cite:PUB00018194]]. It also promotes cell surface expression of the amiloride-sensitive epithelial Na+ channel (ENaC), which is critical in sodium homeostasis and maintenance of extracellular fluid volume [[cite:PUB00092706]].
', 'llm': False, 'checked': False, 'updated': False}, {'text': 'The Phox Homology (PX) domain is a phosphoinositide (PI) binding module present in many proteins with diverse functions. Sorting nexins (SNXs) make up the largest group among PX domain containing proteins. They are involved in regulating membrane traffic and protein sorting in the endosomal system. The PX domain of SNXs binds phosphoinositides (PIs) and targets the protein to PI-enriched membranes [[cite:PUB00084390], [cite:PUB00020213]]. SNXs differ from each other in PI-binding specificity and affinity, and the presence of other protein-protein interaction domains, which help determine subcellular localization and specific function in the endocytic pathway [[cite:PUB00084391], [cite:PUB00068935], [cite:PUB00010010]].
', 'llm': False, 'checked': False, 'updated': False}]" "" "[{'identifier': 'GO:1901981', 'name': 'phosphatidylinositol phosphate binding', 'category': {'code': 'F', 'name': 'molecular_function'}}]" "{'accession': 'IPR001683', 'name': 'Phox homology', 'type': 'Domain', 'children': [{'accession': 'IPR034901', 'name': 'Sorting Nexin 1, PX domain', 'type': 'Domain', 'children': []}, {'accession': 'IPR034902', 'name': 'Sorting nexin 4, PX domain', 'type': 'Domain', 'children': []}, {'accession': 'IPR034909', 'name': 'Neutrophil cytosol factor 1, PX domain', 'type': 'Domain', 'children': []}, {'accession': 'IPR034912', 'name': 'Neutrophil cytosol factor 4, PX domain', 'type': 'Domain', 'children': []}, {'accession': 'IPR035550', 'name': 'Bem1/Scd2, PX domain', 'type': 'Domain', 'children': []}, {'accession': 'IPR035703', 'name': 'SNX18, PX domain', 'type': 'Domain', 'children': []}, {'accession': 'IPR035704', 'name': 'SNX8/Mvp1, PX domain', 'type': 'Domain', 'children': []}, {'accession': 'IPR037426', 'name': 'Sorting nexin-9, PX domain', 'type': 'Domain', 'children': []}, {'accession': 'IPR037436', 'name': 'Sorting nexin-14, PX domain', 'type': 'Domain', 'children': []}, {'accession': 'IPR037437', 'name': 'Sorting nexin-13, PX domain', 'type': 'Domain', 'children': []}, {'accession': 'IPR037833', 'name': 'SNX27, PX domain', 'type': 'Domain', 'children': []}, {'accession': 'IPR037868', 'name': 'Vacuolar protein sorting-associated protein 5, PX domain', 'type': 'Domain', 'children': []}, {'accession': 'IPR037899', 'name': 'SNX25, PX domain', 'type': 'Domain', 'children': []}, {'accession': 'IPR037900', 'name': 'CISK, PX domain', 'type': 'Domain', 'children': []}, {'accession': 'IPR037901', 'name': 'HCLS1-binding protein 3, PX domain', 'type': 'Domain', 'children': []}, {'accession': 'IPR037903', 'name': 'MONaKA, PX domain', 'type': 'Domain', 'children': []}, {'accession': 'IPR037904', 'name': 'Nischarin, PX domain', 'type': 'Domain', 'children': []}, {'accession': 'IPR037907', 'name': 'Vps17, PX domain', 'type': 'Domain', 'children': []}, {'accession': 'IPR037909', 'name': 'SNX19, PX domain', 'type': 'Domain', 'children': []}, {'accession': 'IPR037911', 'name': 'SNX16, PX domain', 'type': 'Domain', 'children': []}, {'accession': 'IPR037916', 'name': 'SNX29, PX domain', 'type': 'Domain', 'children': []}, {'accession': 'IPR037917', 'name': 'Ypt35, PX domain', 'type': 'Domain', 'children': []}, {'accession': 'IPR037918', 'name': 'SNX2, PX domain', 'type': 'Domain', 'children': []}, {'accession': 'IPR037961', 'name': 'SH3PXD2, PX domain', 'type': 'Domain', 'children': []}, {'accession': 'IPR042130', 'name': 'SNX7, PX domain', 'type': 'Domain', 'children': []}, {'accession': 'IPR042132', 'name': 'Ribosomal protein S6 kinase delta-1, PX domain', 'type': 'Domain', 'children': []}, {'accession': 'IPR042133', 'name': 'Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha, PX domain', 'type': 'Domain', 'children': []}, {'accession': 'IPR042134', 'name': 'Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta, PX domain', 'type': 'Domain', 'children': []}, {'accession': 'IPR042135', 'name': 'SNX5, PX domain', 'type': 'Domain', 'children': []}, {'accession': 'IPR042136', 'name': 'SNX6, PX domain', 'type': 'Domain', 'children': []}, {'accession': 'IPR042137', 'name': 'Vertebrate SNX3, PX domain', 'type': 'Domain', 'children': []}, {'accession': 'IPR042138', 'name': 'Fungal SNX3, PX domain', 'type': 'Domain', 'children': []}, {'accession': 'IPR044106', 'name': 'Snx41 /Atg20, PX domain', 'type': 'Domain', 'children': []}]}" "" False False False "{'PUB00084390': {'PMID': 16782399, 'ISBN': None, 'volume': '1761', 'issue': '8', 'year': 2006, 'title': 'The Phox (PX) domain proteins and membrane traffic.', 'URL': None, 'raw_pages': '878-96', 'medline_journal': 'Biochim Biophys Acta', 'ISO_journal': 'Biochim. Biophys. Acta', 'authors': ['Seet LF', 'Hong W.'], 'DOI_URL': 'http://dx.doi.org/10.1016/j.bbalip.2006.04.011'}, 'PUB00084391': {'PMID': 15634208, 'ISBN': None, 'volume': '6', 'issue': '2', 'year': 2005, 'title': 'Sorting nexins--unifying trends and new perspectives.', 'URL': None, 'raw_pages': '75-82', 'medline_journal': 'Traffic', 'ISO_journal': 'Traffic', 'authors': ['Carlton J', 'Bujny M', 'Rutherford A', 'Cullen P.'], 'DOI_URL': 'http://dx.doi.org/10.1111/j.1600-0854.2005.00260.x'}, 'PUB00068935': {'PMID': 16243015, 'ISBN': None, 'volume': '15', 'issue': '20', 'year': 2005, 'title': 'Sorting nexins.', 'URL': None, 'raw_pages': 'R819-20', 'medline_journal': 'Curr Biol', 'ISO_journal': 'Curr. Biol.', 'authors': ['Carlton JG', 'Cullen PJ.'], 'DOI_URL': 'http://dx.doi.org/10.1016/j.cub.2005.10.012'}, 'PUB00020213': {'PMID': 11439176, 'ISBN': None, 'volume': '105', 'issue': '7', 'year': 2001, 'title': 'Phoxy lipids: revealing PX domains as phosphoinositide binding modules.', 'URL': None, 'raw_pages': '817-20', 'medline_journal': 'Cell', 'ISO_journal': 'Cell', 'authors': ['Wishart MJ', 'Taylor GS', 'Dixon JE.'], 'DOI_URL': 'http://dx.doi.org/10.1016/S0092-8674(01)00414-7'}, 'PUB00018194': {'PMID': 11433298, 'ISBN': None, 'volume': '3', 'issue': '7', 'year': 2001, 'title': 'SNX3 regulates endosomal function through its PX-domain-mediated interaction with PtdIns(3)P.', 'URL': None, 'raw_pages': '658-66', 'medline_journal': 'Nat Cell Biol', 'ISO_journal': 'Nat. Cell Biol.', 'authors': ['Xu Y', 'Hortsman H', 'Seet L', 'Wong SH', 'Hong W.'], 'DOI_URL': 'http://dx.doi.org/10.1038/35083051'}, 'PUB00010010': {'PMID': 12461558, 'ISBN': None, 'volume': '3', 'issue': '12', 'year': 2002, 'title': 'Sorting out the cellular functions of sorting nexins.', 'URL': None, 'raw_pages': '919-31', 'medline_journal': 'Nat Rev Mol Cell Biol', 'ISO_journal': 'Nat. Rev. Mol. Cell Biol.', 'authors': ['Worby CA', 'Dixon JE.'], 'DOI_URL': 'http://dx.doi.org/10.1038/nrm974'}, 'PUB00092706': {'PMID': 18632802, 'ISBN': None, 'volume': '295', 'issue': '4', 'year': 2008, 'title': 'Vasopressin-inducible ubiquitin-specific protease 10 increases ENaC cell surface expression by deubiquitylating and stabilizing sorting nexin 3.', 'URL': None, 'raw_pages': 'F889-900', 'medline_journal': 'Am J Physiol Renal Physiol', 'ISO_journal': 'Am. J. Physiol. Renal Physiol.', 'authors': ['Boulkroun S', 'Ruffieux-Daidie D', 'Vitagliano JJ', 'Poirot O', 'Charles RP', 'Lagnaz D', 'Firsov D', 'Kellenberger S', 'Staub O.'], 'DOI_URL': 'https://doi.org/10.1152/ajprenal.00001.2008'}, 'PUB00092707': {'PMID': 18767904, 'ISBN': None, 'volume': '6', 'issue': '9', 'year': 2008, 'title': 'Hrs and SNX3 functions in sorting and membrane invagination within multivesicular bodies.', 'URL': None, 'raw_pages': 'e214', 'medline_journal': 'PLoS Biol', 'ISO_journal': 'PLoS Biol.', 'authors': ['Pons V', 'Luyet PP', 'Morel E', 'Abrami L', 'van der Goot FG', 'Parton RG', 'Gruenberg J.'], 'DOI_URL': 'https://doi.org/10.1371/journal.pbio.0060214'}, 'PUB00029398': {'PMID': 14514667, 'ISBN': None, 'volume': '278', 'issue': '50', 'year': 2003, 'title': 'Crystal structure of the yeast Phox homology (PX) domain protein Grd19p complexed to phosphatidylinositol-3-phosphate.', 'URL': None, 'raw_pages': '50371-6', 'medline_journal': 'J Biol Chem', 'ISO_journal': 'J. Biol. Chem.', 'authors': ['Zhou CZ', 'de La Sierra-Gallay IL', 'Quevillon-Cheruel S', 'Collinet B', 'Minard P', 'Blondeau K', 'Henckes G', 'Aufrere R', 'Leulliot N', 'Graille M', 'Sorel I', 'Savarin P', 'de la Torre F', 'Poupon A', 'Janin J', 'van Tilbeurgh H.'], 'DOI_URL': 'http://dx.doi.org/10.1074/jbc.M304392200'}}" "{'cdd': {'cd07293': 'The phosphoinositide binding Phox Homology domain of Sorting Nexin 3'}}" "{'name': 'Vertebrate SNX3, PX domain', 'short': 'PX_SNX3_Vert'}" "[{'accession': 'IPR036871', 'name': 'PX domain superfamily', 'type': 'homologous_superfamily'}]" "" "" "interpro" "domain" ""