"accession"	"counters"	"cross_references"	"description"	"entry_id"	"go_terms"	"hierarchy"	"integrated"	"is_llm"	"is_reviewed_llm"	"is_updated_llm"	"literature"	"member_databases"	"name"	"overlaps_with"	"representative_structure"	"set_info"	"source_database"	"type"	"wikipedia"
"IPR041998"	"{'subfamilies': 0, 'domain_architectures': 0, 'interactions': 0, 'matches': 838, 'pathways': 2, 'proteins': 838, 'proteomes': 508, 'sets': 0, 'structural_models': {'alphafold': 778, 'bfvd': 0}, 'structures': 6, 'taxa': 1613}"	"{}"	"[{'text': '<p>This entry represents the 7TM domain found in histamine H3 receptor (HRH3 or H3R), which belongs to the class A of GPCRs. Histamine plays a key role as chemical mediator and neurotransmitter in various physiological and pathophysiological processes in the central and peripheral nervous system. Histamine exerts its functions by binding to four different G protein-coupled receptors (H1-H4). The H3 and H4 receptors couple to the G(i)-proteins, which leading to the inhibition of cAMP formation [[cite:PUB00092192]]. The H3R receptor functions as a presynaptic autoreceptors controlling histamine release and synthesis [[cite:PUB00092190]]. The H4R plays an important role in histamine-mediated chemotaxis in mast cells and eosinophils [[cite:PUB00092191]].</p>', 'llm': False, 'checked': False, 'updated': False}]"	""	""	"{'accession': 'IPR017452', 'name': 'GPCR, rhodopsin-like, 7TM', 'type': 'Domain', 'children': [{'accession': 'IPR041998', 'name': 'Histamine H3 receptor, 7TM', 'type': 'Domain', 'children': []}, {'accession': 'IPR043523', 'name': 'G protein-coupled receptor 176, rhodopsin-like, 7TM', 'type': 'Domain', 'children': []}, {'accession': 'IPR044734', 'name': 'G protein-coupled receptor 35, 7TM', 'type': 'Domain', 'children': []}, {'accession': 'IPR047829', 'name': 'G protein-coupled receptor 19, 7TM', 'type': 'Domain', 'children': []}, {'accession': 'IPR047836', 'name': 'G protein-coupled receptor 174, 7TM', 'type': 'Domain', 'children': []}, {'accession': 'IPR048057', 'name': 'Probable G protein-coupled receptor 34, 7TM', 'type': 'Domain', 'children': []}]}"	""	False	False	False	"{'PUB00092190': {'PMID': 24636456, 'ISBN': None, 'volume': '37', 'issue': '4', 'year': 2014, 'title': 'The other side of the histamine H3 receptor.', 'URL': None, 'raw_pages': '191-9', 'medline_journal': 'Trends Neurosci', 'ISO_journal': 'Trends Neurosci.', 'authors': ['Ellenbroek BA', 'Ghiabi B.'], 'DOI_URL': 'https://doi.org/10.1016/j.tins.2014.02.007'}, 'PUB00092191': {'PMID': 22652766, 'ISBN': None, 'volume': '17', 'issue': None, 'year': 2012, 'title': 'Molecular pharmacology of histamine H4 receptors.', 'URL': None, 'raw_pages': '2089-106', 'medline_journal': 'Front Biosci (Landmark Ed)', 'ISO_journal': 'Front Biosci (Landmark Ed)', 'authors': ['Nijmeijer S', 'de Graaf C', 'Leurs R', 'Vischer HF.'], 'DOI_URL': 'https://doi.org/10.2741/4039'}, 'PUB00092192': {'PMID': 22202071, 'ISBN': None, 'volume': '4', 'issue': None, 'year': 2012, 'title': 'Histamine receptor subtypes: a century of rational drug design.', 'URL': None, 'raw_pages': '461-88', 'medline_journal': 'Front Biosci (Schol Ed)', 'ISO_journal': 'Front Biosci (Schol Ed)', 'authors': ['Walter M', 'Stark H.'], 'DOI_URL': 'https://doi.org/10.2741/279'}}"	"{'cdd': {'cd15296': 'histamine receptor subtypes H3R and H3R-like, member of the class A family of seven-transmembrane G protein-coupled receptors'}}"	"{'name': 'Histamine H3 receptor, 7TM', 'short': '7tmA_HRH3'}"	""	""	""	"interpro"	"domain"	""