{"metadata":{"accession":"IPR041998","entry_id":null,"type":"domain","go_terms":null,"source_database":"interpro","member_databases":{"cdd":{"cd15296":"histamine receptor subtypes H3R and H3R-like, member of the class A family of seven-transmembrane G protein-coupled receptors"}},"integrated":null,"hierarchy":{"accession":"IPR017452","name":"GPCR, rhodopsin-like, 7TM","type":"Domain","children":[{"accession":"IPR041998","name":"Histamine H3 receptor, 7TM","type":"Domain","children":[]},{"accession":"IPR043523","name":"G protein-coupled receptor 176, rhodopsin-like, 7TM","type":"Domain","children":[]},{"accession":"IPR044734","name":"G protein-coupled receptor 35, 7TM","type":"Domain","children":[]},{"accession":"IPR047829","name":"G protein-coupled receptor 19, 7TM","type":"Domain","children":[]},{"accession":"IPR047836","name":"G protein-coupled receptor 174, 7TM","type":"Domain","children":[]},{"accession":"IPR048057","name":"Probable G protein-coupled receptor 34, 7TM","type":"Domain","children":[]}]},"name":{"name":"Histamine H3 receptor, 7TM","short":"7tmA_HRH3"},"description":[{"text":"<p>This entry represents the 7TM domain found in histamine H3 receptor (HRH3 or H3R), which belongs to the class A of GPCRs. Histamine plays a key role as chemical mediator and neurotransmitter in various physiological and pathophysiological processes in the central and peripheral nervous system. Histamine exerts its functions by binding to four different G protein-coupled receptors (H1-H4). The H3 and H4 receptors couple to the G(i)-proteins, which leading to the inhibition of cAMP formation [[cite:PUB00092192]]. The H3R receptor functions as a presynaptic autoreceptors controlling histamine release and synthesis [[cite:PUB00092190]]. The H4R plays an important role in histamine-mediated chemotaxis in mast cells and eosinophils [[cite:PUB00092191]].</p>","llm":false,"checked":false,"updated":false}],"wikipedia":null,"literature":{"PUB00092190":{"PMID":24636456,"ISBN":null,"volume":"37","issue":"4","year":2014,"title":"The other side of the histamine H3 receptor.","URL":null,"raw_pages":"191-9","medline_journal":"Trends Neurosci","ISO_journal":"Trends Neurosci.","authors":["Ellenbroek BA","Ghiabi B."],"DOI_URL":"https://doi.org/10.1016/j.tins.2014.02.007"},"PUB00092191":{"PMID":22652766,"ISBN":null,"volume":"17","issue":null,"year":2012,"title":"Molecular pharmacology of histamine H4 receptors.","URL":null,"raw_pages":"2089-106","medline_journal":"Front Biosci (Landmark Ed)","ISO_journal":"Front Biosci (Landmark Ed)","authors":["Nijmeijer S","de Graaf C","Leurs R","Vischer HF."],"DOI_URL":"https://doi.org/10.2741/4039"},"PUB00092192":{"PMID":22202071,"ISBN":null,"volume":"4","issue":null,"year":2012,"title":"Histamine receptor subtypes: a century of rational drug design.","URL":null,"raw_pages":"461-88","medline_journal":"Front Biosci (Schol Ed)","ISO_journal":"Front Biosci (Schol Ed)","authors":["Walter M","Stark H."],"DOI_URL":"https://doi.org/10.2741/279"}},"set_info":null,"overlaps_with":null,"counters":{"subfamilies":0,"domain_architectures":0,"interactions":0,"matches":838,"pathways":2,"proteins":838,"proteomes":508,"sets":0,"structural_models":{"alphafold":778,"bfvd":0},"structures":6,"taxa":1613},"entry_annotations":{},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}