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{
"metadata": {
"accession": "IPR041998",
"entry_id": null,
"type": "domain",
"go_terms": null,
"source_database": "interpro",
"member_databases": {
"cdd": {
"cd15296": "histamine receptor subtypes H3R and H3R-like, member of the class A family of seven-transmembrane G protein-coupled receptors"
}
},
"integrated": null,
"hierarchy": {
"accession": "IPR017452",
"name": "GPCR, rhodopsin-like, 7TM",
"type": "Domain",
"children": [
{
"accession": "IPR041998",
"name": "Histamine H3 receptor, 7TM",
"type": "Domain",
"children": []
},
{
"accession": "IPR043523",
"name": "G protein-coupled receptor 176, rhodopsin-like, 7TM",
"type": "Domain",
"children": []
},
{
"accession": "IPR044734",
"name": "G protein-coupled receptor 35, 7TM",
"type": "Domain",
"children": []
},
{
"accession": "IPR047829",
"name": "G protein-coupled receptor 19, 7TM",
"type": "Domain",
"children": []
},
{
"accession": "IPR047836",
"name": "G protein-coupled receptor 174, 7TM",
"type": "Domain",
"children": []
},
{
"accession": "IPR048057",
"name": "Probable G protein-coupled receptor 34, 7TM",
"type": "Domain",
"children": []
}
]
},
"name": {
"name": "Histamine H3 receptor, 7TM",
"short": "7tmA_HRH3"
},
"description": [
{
"text": "<p>This entry represents the 7TM domain found in histamine H3 receptor (HRH3 or H3R), which belongs to the class A of GPCRs. Histamine plays a key role as chemical mediator and neurotransmitter in various physiological and pathophysiological processes in the central and peripheral nervous system. Histamine exerts its functions by binding to four different G protein-coupled receptors (H1-H4). The H3 and H4 receptors couple to the G(i)-proteins, which leading to the inhibition of cAMP formation [[cite:PUB00092192]]. The H3R receptor functions as a presynaptic autoreceptors controlling histamine release and synthesis [[cite:PUB00092190]]. The H4R plays an important role in histamine-mediated chemotaxis in mast cells and eosinophils [[cite:PUB00092191]].</p>",
"llm": false,
"checked": false,
"updated": false
}
],
"wikipedia": null,
"literature": {
"PUB00092190": {
"PMID": 24636456,
"ISBN": null,
"volume": "37",
"issue": "4",
"year": 2014,
"title": "The other side of the histamine H3 receptor.",
"URL": null,
"raw_pages": "191-9",
"medline_journal": "Trends Neurosci",
"ISO_journal": "Trends Neurosci.",
"authors": [
"Ellenbroek BA",
"Ghiabi B."
],
"DOI_URL": "https://doi.org/10.1016/j.tins.2014.02.007"
},
"PUB00092191": {
"PMID": 22652766,
"ISBN": null,
"volume": "17",
"issue": null,
"year": 2012,
"title": "Molecular pharmacology of histamine H4 receptors.",
"URL": null,
"raw_pages": "2089-106",
"medline_journal": "Front Biosci (Landmark Ed)",
"ISO_journal": "Front Biosci (Landmark Ed)",
"authors": [
"Nijmeijer S",
"de Graaf C",
"Leurs R",
"Vischer HF."
],
"DOI_URL": "https://doi.org/10.2741/4039"
},
"PUB00092192": {
"PMID": 22202071,
"ISBN": null,
"volume": "4",
"issue": null,
"year": 2012,
"title": "Histamine receptor subtypes: a century of rational drug design.",
"URL": null,
"raw_pages": "461-88",
"medline_journal": "Front Biosci (Schol Ed)",
"ISO_journal": "Front Biosci (Schol Ed)",
"authors": [
"Walter M",
"Stark H."
],
"DOI_URL": "https://doi.org/10.2741/279"
}
},
"set_info": null,
"overlaps_with": null,
"counters": {
"subfamilies": 0,
"domain_architectures": 0,
"interactions": 0,
"matches": 838,
"pathways": 2,
"proteins": 838,
"proteomes": 508,
"sets": 0,
"structural_models": {
"alphafold": 778,
"bfvd": 0
},
"structures": 6,
"taxa": 1613
},
"entry_annotations": {},
"cross_references": {},
"is_llm": false,
"is_reviewed_llm": false,
"is_updated_llm": false,
"representative_structure": null
}
}
