"accession"	"counters"	"cross_references"	"description"	"entry_id"	"go_terms"	"hierarchy"	"integrated"	"is_llm"	"is_reviewed_llm"	"is_updated_llm"	"literature"	"member_databases"	"name"	"overlaps_with"	"representative_structure"	"set_info"	"source_database"	"type"	"wikipedia"
"IPR038633"	"{'subfamilies': 0, 'domain_architectures': 0, 'interactions': 0, 'matches': 6083, 'pathways': 393, 'proteins': 6062, 'proteomes': 3139, 'sets': 0, 'structural_models': {'alphafold': 5567, 'bfvd': 0}, 'structures': 42, 'taxa': 10876}"	"{}"	"[{'text': ""<p>This superfamily includes Rpn13 from budding yeasts and its homologue, ADRM1 from animals.</p>\n\n<p>Rpn13 is a subunit and an ubiquitin receptor of the 19S regulatory particle of the 26S proteasome lid. The 26S proteasome is a huge macromolecular protein-degradation machine consisting of a proteolytically active 20S core, in the form of four disc-like proteins, and one or two 19S regulatory particles. The regulatory particle(s) sit on the top and or bottom of the core, de-ubiquitinate the substrate peptides, unfold them and guide them into the narrow channel through the centre of the core. Rpn13 and its homologues dock onto the regulatory particle through the N-terminal region which binds Rpn2. The C-terminal part of the domain binds de-ubiquitinating enzyme Uch37/UCHL5 and enhances its isopeptidase activity. Rpn13 binds ubiquitin via a conserved amino-terminal region called the pleckstrin-like receptor for ubiquitin, termed Pru, domain [[cite:PUB00053442]]. The domain forms two contiguous anti-parallel β-sheets with a configuration similar to the pleckstrin-homology domain (PHD) fold [[cite:PUB00049233], [cite:PUB00054318]]. Rpn13's ability to bind ubiquitin and the proteasome subunit Rpn2/S1 simultaneously supports evidence of its role as a ubiquitin receptor. Finally, when complexed to di-ubiquitin, via the Pru, and Uch37 via the C-terminal part, it frees up the distal ubiquitin for de-ubiquitination by the Uch37 [[cite:PUB00049233]].</p>"", 'llm': False, 'checked': False, 'updated': False}, {'text': '<p>This superfamily represents the Pru (pleckstrin-like receptor for the Ub) domain.</p>', 'llm': False, 'checked': False, 'updated': False}]"	""	""	"{'accession': 'IPR038633', 'name': 'Proteasomal ubiquitin receptor Rpn13/ADRM1, Pru domain superfamily', 'type': 'Homologous_superfamily', 'children': []}"	""	False	False	False	"{'PUB00054318': {'PMID': 20471946, 'ISBN': None, 'volume': '38', 'issue': '3', 'year': 2010, 'title': 'Structure of proteasome ubiquitin receptor hRpn13 and its activation by the scaffolding protein hRpn2.', 'URL': None, 'raw_pages': '404-15', 'medline_journal': 'Mol Cell', 'ISO_journal': 'Mol. Cell', 'authors': ['Chen X', 'Lee BH', 'Finley D', 'Walters KJ.'], 'DOI_URL': 'http://dx.doi.org/10.1016/j.molcel.2010.04.019'}, 'PUB00053442': {'PMID': 18497817, 'ISBN': None, 'volume': '453', 'issue': '7194', 'year': 2008, 'title': 'Proteasome subunit Rpn13 is a novel ubiquitin receptor.', 'URL': None, 'raw_pages': '481-8', 'medline_journal': 'Nature', 'ISO_journal': 'Nature', 'authors': ['Husnjak K', 'Elsasser S', 'Zhang N', 'Chen X', 'Randles L', 'Shi Y', 'Hofmann K', 'Walters KJ', 'Finley D', 'Dikic I.'], 'DOI_URL': 'http://dx.doi.org/10.1038/nature06926'}, 'PUB00049233': {'PMID': 18497827, 'ISBN': None, 'volume': '453', 'issue': '7194', 'year': 2008, 'title': 'Ubiquitin docking at the proteasome through a novel pleckstrin-homology domain interaction.', 'URL': None, 'raw_pages': '548-52', 'medline_journal': 'Nature', 'ISO_journal': 'Nature', 'authors': ['Schreiner P', 'Chen X', 'Husnjak K', 'Randles L', 'Zhang N', 'Elsasser S', 'Finley D', 'Dikic I', 'Walters KJ', 'Groll M.'], 'DOI_URL': 'http://dx.doi.org/10.1038/nature06924'}}"	"{'cathgene3d': {'G3DSA:2.30.29.70': 'Proteasomal ubiquitin receptor Rpn13/ADRM1'}}"	"{'name': 'Proteasomal ubiquitin receptor Rpn13/ADRM1, Pru domain superfamily', 'short': 'Rpn13/ADRM1_Pru_sf'}"	"[{'accession': 'IPR044868', 'name': 'Rpn13/ADRM1, Pru domain', 'type': 'domain'}, {'accession': 'IPR006773', 'name': 'Proteasomal ubiquitin receptor Rpn13/ADRM1', 'type': 'family'}]"	"{'accession': '5v1y', 'name': 'Crystal structure of the ternary RPN13 PRU-RPN2 (940-953)-ubiquitin complex'}"	""	"interpro"	"homologous_superfamily"	""