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InterPro-Version: 108.0
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{
"metadata": {
"accession": "IPR037837",
"entry_id": null,
"type": "domain",
"go_terms": [
{
"identifier": "GO:0007229",
"name": "integrin-mediated signaling pathway",
"category": {
"code": "P",
"name": "biological_process"
}
}
],
"source_database": "interpro",
"member_databases": {
"cdd": {
"cd01237": "Fermitin family pleckstrin homology (PH) domain"
}
},
"integrated": null,
"hierarchy": {
"accession": "IPR001849",
"name": "Pleckstrin homology domain",
"type": "Domain",
"children": [
{
"accession": "IPR001605",
"name": "Pleckstrin homology domain, spectrin-type",
"type": "Domain",
"children": []
},
{
"accession": "IPR024774",
"name": "Pleckstrin homology domain, Mcp5-type",
"type": "Domain",
"children": []
},
{
"accession": "IPR033511",
"name": "Rho guanine nucleotide exchange factor Cdc24/Scd1, PH domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR035939",
"name": "FGD1, N-terminal PH domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR035941",
"name": "FGD1-4, C-terminal PH domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR037743",
"name": "FGD6, N-terminal PH domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR037744",
"name": "ARHGEF18, PH domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR037747",
"name": "Dok-7, PH domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR037773",
"name": "RASA2, PH domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR037774",
"name": "RASA3, PH domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR037777",
"name": "RASA4, PH domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR037779",
"name": "SynGAP, PH domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR037801",
"name": "ARHGEF12, PH domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR037803",
"name": "Rho guanine nucleotide exchange factor 11, PH domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR037806",
"name": "ARHGEF2, PH domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR037810",
"name": "PHLDB1/2/3, PH domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR037812",
"name": "PLEKHM3, PH domain 1",
"type": "Domain",
"children": []
},
{
"accession": "IPR037816",
"name": "DOK4/5/6, PH domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR037819",
"name": "ARHGEF28, PH domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR037837",
"name": "Kindlin/fermitin, PH domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR037839",
"name": "PLEKHN1, PH domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR037840",
"name": "Anillin, PH domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR037844",
"name": "ASAP, PH domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR037849",
"name": "ADAP, PH domain 1",
"type": "Domain",
"children": []
},
{
"accession": "IPR037851",
"name": "ADAP, PH domain 2",
"type": "Domain",
"children": []
},
{
"accession": "IPR037865",
"name": "Active breakpoint cluster region-related protein, PH domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR039026",
"name": "Protein Kinase B, pleckstrin homology domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR039483",
"name": "Meiotic expression up-regulated protein 6, PH domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR039486",
"name": "Mug56/Spo71, PH domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR039597",
"name": "Myosin phosphatase-RhoA interacting protein, PH domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR039665",
"name": "APBB1IP, PH domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR040392",
"name": "PKHA4-7, PH domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR041020",
"name": "ARHGEF1-like, PH domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR041675",
"name": "Pleckstrin homology domain 5",
"type": "Domain",
"children": []
},
{
"accession": "IPR041680",
"name": "Pleckstrin homology domain 8",
"type": "Domain",
"children": []
},
{
"accession": "IPR041681",
"name": "Pleckstrin homology domain 9",
"type": "Domain",
"children": []
},
{
"accession": "IPR042067",
"name": "Sip3, PH domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR042827",
"name": "PLEKHM1, PH domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR043453",
"name": "Slm1, PH domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR046376",
"name": "RhoGEF 6/7, PH domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR046869",
"name": "SLM1/RGC1-like, PH domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR047225",
"name": "GRAF, PH domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR047236",
"name": "DCC-interacting protein 13-alpha/beta, PH domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR047887",
"name": "ARHGAP20, PH domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR049780",
"name": "Kinesin-like protein KIF1A/B, pleckstrin homology domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR055230",
"name": "Tiam1/2, second PH-like domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR055251",
"name": "SOS1/NGEF-like, PH domain",
"type": "Domain",
"children": [
{
"accession": "IPR035534",
"name": "DBS, PH domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR037797",
"name": "FGD2, N-terminal PH domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR037832",
"name": "Vav, PH domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR037853",
"name": "Net1, PH domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR043324",
"name": "PKHG1/2/3, pleckstrin homology domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR044129",
"name": "Rho guanine nucleotide exchange factor 3, PH domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR047054",
"name": "Kalirin/Triple functional domain protein, pleckstrin homology (PH) domain 1",
"type": "Domain",
"children": []
}
]
},
{
"accession": "IPR057837",
"name": "SWAP70, PH domain",
"type": "Domain",
"children": []
}
]
},
"name": {
"name": "Kindlin/fermitin, PH domain",
"short": "PH_Kindlin/fermitin"
},
"description": [
{
"text": "<p>Fermitin, also known as Unc-112-related protein [[cite:PUB00087692]], functions as a mediator of integrin inside-out signalling. The recruitment of Fermitin proteins and Talin to the membrane mediates the terminal event of integrin signalling, via interaction with integrin beta subunits [[cite:PUB00087697]]. Fermatin has a FERM domain interrupted with a pleckstrin homology (PH) domain [[cite:PUB00087693]]. Fermitin family homologues (Fermt1, 2, and 3, also known as Kindlins) are each encoded by a different gene. In mammalian studies, Fermt1 is generally expressed in epithelial cells, Fermt2 is expressed in muscle tissues, and Fermt3 is expressed in hematopoietic lineages. Specifically Fermt2 is expressed in smooth and striated muscle tissues in mice and in the somites (a trunk muscle precursor) and neural crest in Xenopus embryos. As such it has been proposed that Fermt2 plays a role in cardiomyocyte and neural crest differentiation. Expression of mammalian Fermt3 is associated with hematopoietic lineages: the anterior ventral blood islands, vitelline veins, and early myeloid cells. In Xenopus embryos this expression, also include the notochord and cement gland [[cite:PUB00087694], [cite:PUB00087696]].</p>",
"llm": false,
"checked": false,
"updated": false
},
{
"text": "<p>This entry represents the PH domain of fermitins.</p>",
"llm": false,
"checked": false,
"updated": false
}
],
"wikipedia": null,
"literature": {
"PUB00087692": {
"PMID": 12697302,
"ISBN": null,
"volume": "1637",
"issue": "3",
"year": 2003,
"title": "URP1: a member of a novel family of PH and FERM domain-containing membrane-associated proteins is significantly over-expressed in lung and colon carcinomas.",
"URL": null,
"raw_pages": "207-16",
"medline_journal": "Biochim Biophys Acta",
"ISO_journal": "Biochim. Biophys. Acta",
"authors": [
"Weinstein EJ",
"Bourner M",
"Head R",
"Zakeri H",
"Bauer C",
"Mazzarella R."
],
"DOI_URL": "https://doi.org/10.1016/S0925-4439(03)00035-8"
},
"PUB00087693": {
"PMID": 22030399,
"ISBN": null,
"volume": "286",
"issue": "50",
"year": 2011,
"title": "Structural basis of phosphoinositide binding to kindlin-2 protein pleckstrin homology domain in regulating integrin activation.",
"URL": null,
"raw_pages": "43334-42",
"medline_journal": "J Biol Chem",
"ISO_journal": "J. Biol. Chem.",
"authors": [
"Liu J",
"Fukuda K",
"Xu Z",
"Ma YQ",
"Hirbawi J",
"Mao X",
"Wu C",
"Plow EF",
"Qin J."
],
"DOI_URL": "https://doi.org/10.1074/jbc.M111.295352"
},
"PUB00087694": {
"PMID": 25173804,
"ISBN": null,
"volume": "133",
"issue": null,
"year": 2014,
"title": "Diverse functions of kindlin/fermitin proteins during embryonic development in Xenopus laevis.",
"URL": null,
"raw_pages": "203-17",
"medline_journal": "Mech Dev",
"ISO_journal": "Mech. Dev.",
"authors": [
"Rozario T",
"Mead PE",
"DeSimone DW."
],
"DOI_URL": "https://doi.org/10.1016/j.mod.2014.07.004"
},
"PUB00087696": {
"PMID": 21761481,
"ISBN": null,
"volume": "240",
"issue": "8",
"year": 2011,
"title": "Developmental expression of the fermitin/kindlin gene family in Xenopus laevis embryos.",
"URL": null,
"raw_pages": "1958-63",
"medline_journal": "Dev Dyn",
"ISO_journal": "Dev. Dyn.",
"authors": [
"Canning CA",
"Chan JS",
"Common JE",
"Lane EB",
"Jones CM."
],
"DOI_URL": "https://doi.org/10.1002/dvdy.22683"
},
"PUB00087697": {
"PMID": 24477625,
"ISBN": null,
"volume": "8",
"issue": "1",
"year": 2014,
"title": "Talin and kindlin: the one-two punch in integrin activation.",
"URL": null,
"raw_pages": "6-16",
"medline_journal": "Front Med",
"ISO_journal": "Front Med",
"authors": [
"Ye F",
"Snider AK",
"Ginsberg MH."
],
"DOI_URL": "https://doi.org/10.1007/s11684-014-0317-3"
}
},
"set_info": null,
"overlaps_with": [
{
"accession": "IPR011993",
"name": "PH-like domain superfamily",
"type": "homologous_superfamily"
}
],
"counters": {
"subfamilies": 0,
"domain_architectures": 0,
"interactions": 0,
"matches": 3906,
"pathways": 18,
"proteins": 3906,
"proteomes": 983,
"sets": 0,
"structural_models": {
"alphafold": 3645,
"bfvd": 0
},
"structures": 6,
"taxa": 3265
},
"entry_annotations": {},
"cross_references": {},
"is_llm": false,
"is_reviewed_llm": false,
"is_updated_llm": false,
"representative_structure": {
"accession": "4f7h",
"name": "The crystal structure of kindlin-2 pleckstrin homology domain in free form"
}
}
}
