ITK (also known as Tsk or Emt) is a member of the Tec family, which is a group of nonreceptor tyrosine kinases containing Src homology protein interaction domains (SH3, SH2) N-terminal to the catalytic tyr kinase domain. It also contains an N-terminal pleckstrin homology (PH) domain, which binds the products of PI3K and allows membrane recruitment and activation [[cite:PUB00085616]], and the Tec homology (TH) domain, which contains proline-rich and zinc-binding regions.
","llm":false,"checked":false,"updated":false},{"text":"This entry represents the SH3 domain of ITK.
","llm":false,"checked":false,"updated":false}],"wikipedia":null,"literature":{"PUB00085613":{"PMID":16931156,"ISBN":null,"volume":"27","issue":"10","year":2006,"title":"Itk and Th2 responses: action but no reaction.","URL":null,"raw_pages":"453-60","medline_journal":"Trends Immunol","ISO_journal":"Trends Immunol.","authors":["Kosaka Y","Felices M","Berg LJ."],"DOI_URL":"https://doi.org/10.1016/j.it.2006.08.006"},"PUB00085615":{"PMID":17420479,"ISBN":null,"volume":"104","issue":"16","year":2007,"title":"SLP-76 mediates and maintains activation of the Tec family kinase ITK via the T cell antigen receptor-induced association between SLP-76 and ITK.","URL":null,"raw_pages":"6638-43","medline_journal":"Proc Natl Acad Sci U S A","ISO_journal":"Proc. Natl. Acad. Sci. U.S.A.","authors":["Bogin Y","Ainey C","Beach D","Yablonski D."],"DOI_URL":"https://doi.org/10.1073/pnas.0609771104"},"PUB00085616":{"PMID":17412921,"ISBN":null,"volume":"316","issue":"5826","year":2007,"title":"Positive regulation of Itk PH domain function by soluble IP4.","URL":null,"raw_pages":"886-9","medline_journal":"Science","ISO_journal":"Science","authors":["Huang YH","Grasis JA","Miller AT","Xu R","Soonthornvacharin S","Andreotti AH","Tsoukas CD","Cooke MP","Sauer K."],"DOI_URL":"https://doi.org/10.1126/science.1138684"},"PUB00085617":{"PMID":15123627,"ISBN":null,"volume":"279","issue":"28","year":2004,"title":"Regulation of CXC chemokine receptor 4-mediated migration by the Tec family tyrosine kinase ITK.","URL":null,"raw_pages":"29816-20","medline_journal":"J Biol Chem","ISO_journal":"J. Biol. Chem.","authors":["Fischer AM","Mercer JC","Iyer A","Ragin MJ","August A."],"DOI_URL":"https://doi.org/10.1074/jbc.M312848200"},"PUB00085618":{"PMID":9701039,"ISBN":null,"volume":"10","issue":"7","year":1998,"title":"CD2-mediated activation of the Tec-family tyrosine kinase ITK is controlled by proline-rich stretch-4 of the CD2 cytoplasmic tail.","URL":null,"raw_pages":"1009-16","medline_journal":"Int Immunol","ISO_journal":"Int. Immunol.","authors":["King PD","Sadra A","Teng JM","Bell GM","Dupont B."],"DOI_URL":"https://doi.org/10.1093/intimm/10.7.1009"},"PUB00085619":{"PMID":24270545,"ISBN":null,"volume":"19","issue":"12","year":2013,"title":"CD28 and ITK signals regulate autoreactive T cell trafficking.","URL":null,"raw_pages":"1632-7","medline_journal":"Nat Med","ISO_journal":"Nat. Med.","authors":["Jain N","Miu B","Jiang JK","McKinstry KK","Prince A","Swain SL","Greiner DL","Thomas CJ","Sanderson MJ","Berg LJ","Kang J."],"DOI_URL":"https://doi.org/10.1038/nm.3393"},"PUB00085620":{"PMID":17479128,"ISBN":null,"volume":"7","issue":"6","year":2007,"title":"Signalling through TEC kinases regulates conventional versus innate CD8(+) T-cell development.","URL":null,"raw_pages":"479-85","medline_journal":"Nat Rev Immunol","ISO_journal":"Nat. Rev. Immunol.","authors":["Berg LJ."],"DOI_URL":"https://doi.org/10.1038/nri2091"},"PUB00085621":{"PMID":19290924,"ISBN":null,"volume":"228","issue":"1","year":2009,"title":"The Tec kinases Itk and Rlk regulate conventional versus innate T-cell development.","URL":null,"raw_pages":"115-31","medline_journal":"Immunol Rev","ISO_journal":"Immunol. Rev.","authors":["Prince AL","Yin CC","Enos ME","Felices M","Berg LJ."],"DOI_URL":"https://doi.org/10.1111/j.1600-065X.2008.00746.x"}},"set_info":null,"overlaps_with":[{"accession":"IPR036028","name":"SH3-like domain superfamily","type":"homologous_superfamily"}],"counters":{"subfamilies":0,"domain_architectures":0,"interactions":0,"matches":370,"pathways":4,"proteins":370,"proteomes":295,"sets":0,"structural_models":{"alphafold":348,"bfvd":0},"structures":7,"taxa":973},"entry_annotations":{},"cross_references":{},"is_llm":false,"is_reviewed_llm":false,"is_updated_llm":false,"representative_structure":null}}