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{
"metadata": {
"accession": "IPR035583",
"entry_id": null,
"type": "domain",
"go_terms": null,
"source_database": "interpro",
"member_databases": {
"cdd": {
"cd11908": "Src Homology 3 domain of Interleukin-2-inducible T-cell Kinase"
}
},
"integrated": null,
"hierarchy": {
"accession": "IPR001452",
"name": "SH3 domain",
"type": "Domain",
"children": [
{
"accession": "IPR028455",
"name": "ABI gene family member 3, SH3 domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR028503",
"name": "Endophilin-B1, SH3 domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR028570",
"name": "Kalirin/Triple functional domain protein, SH3 domain 1",
"type": "Domain",
"children": []
},
{
"accession": "IPR029294",
"name": "Helically-extended SH3 domain",
"type": "Domain",
"children": [
{
"accession": "IPR035540",
"name": "FYB, helically extended SH3 domain",
"type": "Domain",
"children": []
}
]
},
{
"accession": "IPR030642",
"name": "Nephrocystin-1, SH3 domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR030777",
"name": "PSTPIP1, SH3 domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR034889",
"name": "Neutrophil cytosol factor 2, SH3 domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR035449",
"name": "SH3PXD2A, SH3 domain 3",
"type": "Domain",
"children": []
},
{
"accession": "IPR035450",
"name": "SH3PXD2A, SH3 domain 1",
"type": "Domain",
"children": []
},
{
"accession": "IPR035452",
"name": "SH3PXD2A, SH3 domain 2",
"type": "Domain",
"children": []
},
{
"accession": "IPR035453",
"name": "SH3PXD2A, SH3 domain 4",
"type": "Domain",
"children": []
},
{
"accession": "IPR035454",
"name": "SH3PXD2A, SH3 domain 5",
"type": "Domain",
"children": []
},
{
"accession": "IPR035456",
"name": "SH3BP4, SH3 domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR035457",
"name": "CRK, N-terminal SH3 domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR035458",
"name": "CRK, C-terminal SH3 domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR035460",
"name": "FCHSD, SH3 domain 1",
"type": "Domain",
"children": []
},
{
"accession": "IPR035462",
"name": "Eps8, SH3 domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR035465",
"name": "Rho GTPase-activating protein 9, SH3 domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR035468",
"name": "SH3D21, SH3 domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR035470",
"name": "Amphiphysin I, SH3 domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR035471",
"name": "Amphiphysin 2, SH3 domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR035473",
"name": "CASK, SH3 domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR035475",
"name": "MPP1, SH3 domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR035477",
"name": "SH3PXD2B, SH3 domain 1",
"type": "Domain",
"children": []
},
{
"accession": "IPR035478",
"name": "SH3PXD2B, SH3 domain 2",
"type": "Domain",
"children": []
},
{
"accession": "IPR035479",
"name": "SH3PXD2B, SH3 domain 3",
"type": "Domain",
"children": []
},
{
"accession": "IPR035480",
"name": "SH3PXD2B, SH3 domain 4",
"type": "Domain",
"children": []
},
{
"accession": "IPR035481",
"name": "GRAF, SH3 domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR035485",
"name": "GRAF2, SH3 domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR035489",
"name": "MYO15B, SH3 domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR035491",
"name": "ARHGAP12, SH3 domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR035492",
"name": "FNBP1, SH3 domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR035493",
"name": "FNBP1L, SH3 domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR035495",
"name": "Caskin-1, SH3 domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR035499",
"name": "Caskin2, SH3 domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR035507",
"name": "Unconventional myosin-Ie/If, SH3 domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR035508",
"name": "STAC1, SH3 domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR035509",
"name": "Stac2, SH3 domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR035511",
"name": "SH3YL1, SH3 domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR035514",
"name": "SPIN90, SH3 domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR035521",
"name": "Fus1, SH3 domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR035522",
"name": "Sho1, SH3 domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR035526",
"name": "Obscurin, SH3 domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR035532",
"name": "DBS, SH3 domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR035535",
"name": "Fungal myosin-I, SH3 domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR035541",
"name": "Neutrophil cytosol factor P40, SH3 domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR035546",
"name": "Neutrophil cytosol factor 2, SH3 domain 1",
"type": "Domain",
"children": []
},
{
"accession": "IPR035548",
"name": "Bem1/Scd2, SH3 domain 1",
"type": "Domain",
"children": []
},
{
"accession": "IPR035549",
"name": "Bem1/Scd2, SH3 domain 2",
"type": "Domain",
"children": []
},
{
"accession": "IPR035551",
"name": "Boi1/2, SH3 domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR035552",
"name": "Mti1, SH3 domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR035553",
"name": "Cytokinesis protein 3, SH3 domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR035554",
"name": "Otoraplin, SH3 domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR035555",
"name": "MIA2, SH3 domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR035556",
"name": "FCHSD2, SH3 domain 2",
"type": "Domain",
"children": []
},
{
"accession": "IPR035557",
"name": "Sorting nexin-18, SH3 domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR035558",
"name": "SNX9, SH3 domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR035559",
"name": "Nck2, SH3 domain 1",
"type": "Domain",
"children": []
},
{
"accession": "IPR035560",
"name": "Nck2, SH3 domain 2",
"type": "Domain",
"children": []
},
{
"accession": "IPR035561",
"name": "Nck2, SH3 domain 3",
"type": "Domain",
"children": []
},
{
"accession": "IPR035562",
"name": "Nck1, SH3 domain 1",
"type": "Domain",
"children": []
},
{
"accession": "IPR035564",
"name": "Nck1, SH3 domain 2",
"type": "Domain",
"children": []
},
{
"accession": "IPR035565",
"name": "Nck1, SH3 domain 3",
"type": "Domain",
"children": []
},
{
"accession": "IPR035572",
"name": "Tyrosine-protein kinase Tec, SH3 domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR035574",
"name": "Tyrosine-protein kinase BTK, SH3 domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR035579",
"name": "Tyrosine-protein kinase TXK, SH3 domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR035583",
"name": "Tyrosine-protein kinase ITK, SH3 domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR035586",
"name": "Phosphatidylinositol 3-kinase regulatory subunit beta, SH3 domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR035591",
"name": "Phosphatidylinositol 3-kinase regulatory subunit alpha, SH3 domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR035592",
"name": "IRTKS, SH3 domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR035593",
"name": "Pinkbar, SH3",
"type": "Domain",
"children": []
},
{
"accession": "IPR035594",
"name": "BAR/IMD domain-containing adapter protein 2, SH3 domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR035596",
"name": "Src-like-adapter, SH3 domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR035597",
"name": "ZO-1, SH3 domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR035598",
"name": "ZO-2, SH3 domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR035599",
"name": "MPP7, SH3 domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR035600",
"name": "MPP4, SH3 domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR035601",
"name": "MPP5, SH3 domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR035602",
"name": "MPP2, SH3 domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR035603",
"name": "MPP6, SH3 domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR035604",
"name": "MPP3, SH3 domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR035605",
"name": "CACNB2, SH3 domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR035606",
"name": "Sorbin and SH3 domain-containing protein 1, third SH3 domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR035607",
"name": "Vinexin, SH3 domain 3",
"type": "Domain",
"children": []
},
{
"accession": "IPR035608",
"name": "Vinexin, SH3 domain 2",
"type": "Domain",
"children": []
},
{
"accession": "IPR035609",
"name": "Vinexin, SH3 domain 1",
"type": "Domain",
"children": []
},
{
"accession": "IPR035610",
"name": "Sorbin and SH3 domain-containing protein 1, first SH3 domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR035611",
"name": "Sorbin and SH3 domain-containing protein 1, second SH3 domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR035612",
"name": "SH3RF3, SH3 domain 3",
"type": "Domain",
"children": []
},
{
"accession": "IPR035629",
"name": "Nebulin, SH3 domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR035630",
"name": "Lasp1, SH3 domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR035631",
"name": "Nebulette, SH3 domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR035632",
"name": "UBASH3B, SH3 domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR035634",
"name": "UBASH3A, SH3 domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR035635",
"name": "Ephexin-1, SH3 domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR035636",
"name": "ARHGEF37, SH3 domain 2",
"type": "Domain",
"children": []
},
{
"accession": "IPR035637",
"name": "JIP2, SH3 domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR035638",
"name": "JIP1, SH3 domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR035640",
"name": "Endophilin B2, SH3 domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR035641",
"name": "GRB2, N-terminal SH3 domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR035643",
"name": "GRB2, C-terminal SH3 domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR035645",
"name": "GRAP, N-terminal SH3 domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR035646",
"name": "GRAP2, C-terminal SH3 domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR035648",
"name": "srGAP1/2/3, SH3 domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR035652",
"name": "RasGAP, SH3 domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR035653",
"name": "Alpha-(1,6)-fucosyltransferase, SH3 domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR035656",
"name": "Nostrin, SH3 domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR035657",
"name": "STAM1, SH3 domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR035675",
"name": "STAM2, SH3 domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR035677",
"name": "ASAP2, SH3 domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR035678",
"name": "srGAP4, SH3 domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR035716",
"name": "Cortactin, SH3 domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR035717",
"name": "Drebrin-like protein, SH3 domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR035718",
"name": "Fungal actin-binding protein 1, second SH3 domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR035719",
"name": "Fungal actin-binding protein 1, first SH3 domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR035720",
"name": "SAM and SH3 domain-containing protein 1, SH3 domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR035721",
"name": "SAM and SH3 domain-containing protein 3, SH3 domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR035723",
"name": "1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2, SH3 domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR035724",
"name": "1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1, SH3 domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR035725",
"name": "Abl Interactor 1, SH3 domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR035726",
"name": "Abl interactor 2, SH3 domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR035728",
"name": "Rho guanine nucleotide exchange factor 9, SH3 domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR035729",
"name": "VAV1 protein, second SH3 domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR035732",
"name": "VAV2 protein, second SH3 domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR035733",
"name": "VAV2 protein, first SH3 domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR035734",
"name": "VAV3 protein, second SH3 domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR035735",
"name": "Shank1, SH3 domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR035736",
"name": "Stac3, first SH3 domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR035737",
"name": "Intersectin-2, first SH3 domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR035738",
"name": "Intersectin-2, second SH3 domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR035739",
"name": "Intersectin-2, third SH3 domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR035740",
"name": "Intersectin-2, fourth SH3 domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR035741",
"name": "Intersectin-2, fifth SH3 domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR035743",
"name": "PACSIN1/PACSIN2, SH3 domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR035744",
"name": "Cas scaffolding protein family member 4, SH3 domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR035745",
"name": "BCAR1, SH3 domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR035746",
"name": "Enhancer of filamentation 1, SH3 domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR035747",
"name": "Embryonal Fyn-associated substrate, SH3 domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR035748",
"name": "Tyrosine-protein kinase Lyn, SH3 domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR035749",
"name": "Lck, SH3 domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR035750",
"name": "Fyn/Yrk, SH3 domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR035751",
"name": "Tyrosine-protein kinase Yes, SH3 domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR035753",
"name": "RIMS-binding protein, second SH3 domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR035755",
"name": "RIMS-binding protein, third SH3 domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR035756",
"name": "Neutrophil cytosol factor 1, first SH3 domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR035757",
"name": "Neutrophil cytosol factor 1, second SH3 domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR035758",
"name": "NADPH oxidase organiser 1, second SH3 domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR035759",
"name": "Disks Large homologue 2, SH3 domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR035760",
"name": "Voltage-dependent L-type calcium channel subunit beta-3, SH3 domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR035763",
"name": "Disks Large homologue 3, SH3 domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR035765",
"name": "Src kinase-associated phosphoprotein 1, SH3 domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR035767",
"name": "Dedicator of cytokinesis 3, SH3 domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR035769",
"name": "Dedicator of cytokinesis 4, SH3 domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR035770",
"name": "SH3 domain-containing kinase-binding protein 1, first SH3 domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR035771",
"name": "SH3 domain-containing kinase-binding protein 1, second SH3 domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR035772",
"name": "SH3 domain-containing kinase-binding protein 1, third SH3 domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR035775",
"name": "CD2-associated protein, first SH3 domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR035776",
"name": "CD2-associated protein, second SH3 domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR035777",
"name": "CD2-associated protein, third SH3 domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR035779",
"name": "MLK1-3, SH3 domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR035788",
"name": "Rho guanine nucleotide exchange factor 6, SH3 domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR035789",
"name": "Rho guanine nucleotide exchange factor 7, SH3 domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR035792",
"name": "E3 ubiquitin-protein ligase SH3RF2, first SH3 domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR035794",
"name": "E3 ubiquitin-protein ligase SH3RF2, second SH3 domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR035795",
"name": "E3 ubiquitin-protein ligase SH3RF1, second SH3 domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR035797",
"name": "ARHGEF16/ARHGEF26, SH3 domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR035800",
"name": "Sla1, first SH3 domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR035816",
"name": "SH3RF1/SH3RF3, fourth SH3 domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR035817",
"name": "Dynamin-binding protein, first N-terminal SH3 domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR035818",
"name": "Dynamin-binding protein, second N-terminal SH3 domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR035819",
"name": "Dynamin-binding protein, third N-terminal SH3 domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR035820",
"name": "Dynamin-binding protein, first C-terminal SH3 domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR035821",
"name": "Sla1, third SH3 domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR035822",
"name": "SH3RF2, third SH3 domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR035823",
"name": "ARHGEF37, first C-terminal SH3 domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR035824",
"name": "Endophilin-A, SH3 domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR035825",
"name": "Alpha Spectrin, SH3 domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR035832",
"name": "Jouberin, SH3 domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR035833",
"name": "SGSM3, SH3 domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR035834",
"name": "SH3 domain-containing protein 19, SH3 domain 1",
"type": "Domain",
"children": []
},
{
"accession": "IPR035835",
"name": "SH3 domain-containing protein 19, SH3 domain 3",
"type": "Domain",
"children": []
},
{
"accession": "IPR035836",
"name": "ASAP1-like, SH3 domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR038016",
"name": "ASAP1, SH3 domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR041615",
"name": "Desmoplakin, SH3 domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR042722",
"name": "RelA-associated inhibitor, SH3 domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR047015",
"name": "VAV3 protein, first SH3 domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR047025",
"name": "Dedicator of cytokinesis protein 1/5, SH3 domain",
"type": "Domain",
"children": []
},
{
"accession": "IPR047053",
"name": "Kalirin/Triple functional domain protein, SH3 domain 2",
"type": "Domain",
"children": []
}
]
},
"name": {
"name": "Tyrosine-protein kinase ITK, SH3 domain",
"short": "ITK_SH3"
},
"description": [
{
"text": "<p>ITK (also known as Tsk or Emt) is a member of the Tec family, which is a group of nonreceptor tyrosine kinases containing Src homology protein interaction domains (SH3, SH2) N-terminal to the catalytic tyr kinase domain. It also contains an N-terminal pleckstrin homology (PH) domain, which binds the products of PI3K and allows membrane recruitment and activation [[cite:PUB00085616]], and the Tec homology (TH) domain, which contains proline-rich and zinc-binding regions.</p>",
"llm": false,
"checked": false,
"updated": false
},
{
"text": "<p>This entry represents the SH3 domain of ITK.</p>",
"llm": false,
"checked": false,
"updated": false
}
],
"wikipedia": null,
"literature": {
"PUB00085613": {
"PMID": 16931156,
"ISBN": null,
"volume": "27",
"issue": "10",
"year": 2006,
"title": "Itk and Th2 responses: action but no reaction.",
"URL": null,
"raw_pages": "453-60",
"medline_journal": "Trends Immunol",
"ISO_journal": "Trends Immunol.",
"authors": [
"Kosaka Y",
"Felices M",
"Berg LJ."
],
"DOI_URL": "https://doi.org/10.1016/j.it.2006.08.006"
},
"PUB00085615": {
"PMID": 17420479,
"ISBN": null,
"volume": "104",
"issue": "16",
"year": 2007,
"title": "SLP-76 mediates and maintains activation of the Tec family kinase ITK via the T cell antigen receptor-induced association between SLP-76 and ITK.",
"URL": null,
"raw_pages": "6638-43",
"medline_journal": "Proc Natl Acad Sci U S A",
"ISO_journal": "Proc. Natl. Acad. Sci. U.S.A.",
"authors": [
"Bogin Y",
"Ainey C",
"Beach D",
"Yablonski D."
],
"DOI_URL": "https://doi.org/10.1073/pnas.0609771104"
},
"PUB00085616": {
"PMID": 17412921,
"ISBN": null,
"volume": "316",
"issue": "5826",
"year": 2007,
"title": "Positive regulation of Itk PH domain function by soluble IP4.",
"URL": null,
"raw_pages": "886-9",
"medline_journal": "Science",
"ISO_journal": "Science",
"authors": [
"Huang YH",
"Grasis JA",
"Miller AT",
"Xu R",
"Soonthornvacharin S",
"Andreotti AH",
"Tsoukas CD",
"Cooke MP",
"Sauer K."
],
"DOI_URL": "https://doi.org/10.1126/science.1138684"
},
"PUB00085617": {
"PMID": 15123627,
"ISBN": null,
"volume": "279",
"issue": "28",
"year": 2004,
"title": "Regulation of CXC chemokine receptor 4-mediated migration by the Tec family tyrosine kinase ITK.",
"URL": null,
"raw_pages": "29816-20",
"medline_journal": "J Biol Chem",
"ISO_journal": "J. Biol. Chem.",
"authors": [
"Fischer AM",
"Mercer JC",
"Iyer A",
"Ragin MJ",
"August A."
],
"DOI_URL": "https://doi.org/10.1074/jbc.M312848200"
},
"PUB00085618": {
"PMID": 9701039,
"ISBN": null,
"volume": "10",
"issue": "7",
"year": 1998,
"title": "CD2-mediated activation of the Tec-family tyrosine kinase ITK is controlled by proline-rich stretch-4 of the CD2 cytoplasmic tail.",
"URL": null,
"raw_pages": "1009-16",
"medline_journal": "Int Immunol",
"ISO_journal": "Int. Immunol.",
"authors": [
"King PD",
"Sadra A",
"Teng JM",
"Bell GM",
"Dupont B."
],
"DOI_URL": "https://doi.org/10.1093/intimm/10.7.1009"
},
"PUB00085619": {
"PMID": 24270545,
"ISBN": null,
"volume": "19",
"issue": "12",
"year": 2013,
"title": "CD28 and ITK signals regulate autoreactive T cell trafficking.",
"URL": null,
"raw_pages": "1632-7",
"medline_journal": "Nat Med",
"ISO_journal": "Nat. Med.",
"authors": [
"Jain N",
"Miu B",
"Jiang JK",
"McKinstry KK",
"Prince A",
"Swain SL",
"Greiner DL",
"Thomas CJ",
"Sanderson MJ",
"Berg LJ",
"Kang J."
],
"DOI_URL": "https://doi.org/10.1038/nm.3393"
},
"PUB00085620": {
"PMID": 17479128,
"ISBN": null,
"volume": "7",
"issue": "6",
"year": 2007,
"title": "Signalling through TEC kinases regulates conventional versus innate CD8(+) T-cell development.",
"URL": null,
"raw_pages": "479-85",
"medline_journal": "Nat Rev Immunol",
"ISO_journal": "Nat. Rev. Immunol.",
"authors": [
"Berg LJ."
],
"DOI_URL": "https://doi.org/10.1038/nri2091"
},
"PUB00085621": {
"PMID": 19290924,
"ISBN": null,
"volume": "228",
"issue": "1",
"year": 2009,
"title": "The Tec kinases Itk and Rlk regulate conventional versus innate T-cell development.",
"URL": null,
"raw_pages": "115-31",
"medline_journal": "Immunol Rev",
"ISO_journal": "Immunol. Rev.",
"authors": [
"Prince AL",
"Yin CC",
"Enos ME",
"Felices M",
"Berg LJ."
],
"DOI_URL": "https://doi.org/10.1111/j.1600-065X.2008.00746.x"
}
},
"set_info": null,
"overlaps_with": [
{
"accession": "IPR036028",
"name": "SH3-like domain superfamily",
"type": "homologous_superfamily"
}
],
"counters": {
"subfamilies": 0,
"domain_architectures": 0,
"interactions": 0,
"matches": 370,
"pathways": 4,
"proteins": 370,
"proteomes": 295,
"sets": 0,
"structural_models": {
"alphafold": 348,
"bfvd": 0
},
"structures": 7,
"taxa": 973
},
"entry_annotations": {},
"cross_references": {},
"is_llm": false,
"is_reviewed_llm": false,
"is_updated_llm": false,
"representative_structure": null
}
}
