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{
    "metadata": {
        "accession": "IPR033644",
        "entry_id": null,
        "type": "domain",
        "go_terms": null,
        "source_database": "interpro",
        "member_databases": {
            "cdd": {
                "cd00419": "Ferrochelatase_C"
            }
        },
        "integrated": null,
        "hierarchy": {
            "accession": "IPR033644",
            "name": "Ferrochelatase, C-terminal",
            "type": "Domain",
            "children": []
        },
        "name": {
            "name": "Ferrochelatase, C-terminal",
            "short": "Ferrochelatase_C"
        },
        "description": [
            {
                "text": "<p>Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is ubiquitous in nature and widely distributed in bacteria and eukaryotes. Recently, some archaeal members have been identified. The oligomeric state of these enzymes varies depending on the presence of a dimerization motif at the C terminus [[cite:PUB00079463]].</p>\r\n\r\n<p>This entry represents the C-terminal domain.</p>",
                "llm": false,
                "checked": false,
                "updated": false
            }
        ],
        "wikipedia": null,
        "literature": {
            "PUB00079463": {
                "PMID": 11215517,
                "ISBN": null,
                "volume": "57",
                "issue": "13-14",
                "year": 2000,
                "title": "Ferrochelatase at the millennium: structures, mechanisms and [2Fe-2S] clusters.",
                "URL": null,
                "raw_pages": "1909-26",
                "medline_journal": "Cell Mol Life Sci",
                "ISO_journal": "Cell. Mol. Life Sci.",
                "authors": [
                    "Dailey HA",
                    "Dailey TA",
                    "Wu CK",
                    "Medlock AE",
                    "Wang KF",
                    "Rose JP",
                    "Wang BC."
                ],
                "DOI_URL": "http://dx.doi.org/10.1007/PL00000672"
            }
        },
        "set_info": null,
        "overlaps_with": null,
        "counters": {
            "subfamilies": 0,
            "domain_architectures": 0,
            "interactions": 0,
            "matches": 27023,
            "pathways": 15,
            "proteins": 27020,
            "proteomes": 17655,
            "sets": 0,
            "structural_models": {
                "alphafold": 20933,
                "bfvd": 0
            },
            "structures": 54,
            "taxa": 31087
        },
        "entry_annotations": {},
        "cross_references": {
            "ec": {
                "displayName": "ENZYME",
                "description": "ENZYME is a repository of information relative to the nomenclature of enzymes. It is primarily based on the recommendations of the Nomenclature Committee of the International Union of Biochemistry and Molecular Biology (IUBMB) and it describes each type of characterized enzyme for which an EC (Enzyme Commission) number has been provided.",
                "rank": 19,
                "accessions": [
                    {
                        "accession": "4.98.1.1",
                        "url": "https://enzyme.expasy.org/EC/4.98.1.1"
                    }
                ]
            }
        },
        "is_llm": false,
        "is_reviewed_llm": false,
        "is_updated_llm": false,
        "representative_structure": null
    }
}